Sustainable cannabinoids purification through twin-column recycling chromatography and green solvents.
Cannabis sativa L.
Cannabinoids
Green solvent
Recycling chromatography
THC depletion
Journal
Analytical and bioanalytical chemistry
ISSN: 1618-2650
Titre abrégé: Anal Bioanal Chem
Pays: Germany
ID NLM: 101134327
Informations de publication
Date de publication:
15 May 2024
15 May 2024
Historique:
received:
18
03
2024
accepted:
07
05
2024
revised:
06
05
2024
medline:
15
5
2024
pubmed:
15
5
2024
entrez:
15
5
2024
Statut:
aheadofprint
Résumé
In the present study, twin-column recycling chromatography has been employed for the purification of a Cannabis extract by using a green solvent, ethanol, as the mobile phase. In particular, the complete removal of the psychoactive tetrahydrocannabinol (THC) from a Cannabis extract rich in cannabidiol (CBD) was achieved under continuous conditions. The performance of the method, in terms of compound purity, recovery, productivity and solvent consumption, was compared to that of traditional batch operations showing the potential of the twin-column recycling approach. The employment of a theoretical model to predict the band profiles of the two compounds during the recycling process has facilitated method development, thus further contributing to process sustainability by avoiding trial and error attempts or at least decreasing the number of steps significantly.
Identifiants
pubmed: 38748248
doi: 10.1007/s00216-024-05332-7
pii: 10.1007/s00216-024-05332-7
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ministero dell'Universitá e della Ricerca
ID : P2022PTYWP
Informations de copyright
© 2024. The Author(s).
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