DNA-empowered synthetic cells as minimalistic life forms.


Journal

Nature reviews. Chemistry
ISSN: 2397-3358
Titre abrégé: Nat Rev Chem
Pays: England
ID NLM: 101703631

Informations de publication

Date de publication:
15 May 2024
Historique:
accepted: 12 04 2024
medline: 16 5 2024
pubmed: 16 5 2024
entrez: 15 5 2024
Statut: aheadofprint

Résumé

Cells, the fundamental units of life, orchestrate intricate functions - motility, adaptation, replication, communication, and self-organization within tissues. Originating from spatiotemporally organized structures and machinery, coupled with information processing in signalling networks, cells embody the 'sensor-processor-actuator' paradigm. Can we glean insights from these processes to construct primitive artificial systems with life-like properties? Using de novo design approaches, what can we uncover about the evolutionary path of life? This Review discusses the strides made in crafting synthetic cells, utilizing the powerful toolbox of structural and dynamic DNA nanoscience. We describe how DNA can serve as a versatile tool for engineering entire synthetic cells or subcellular entities, and how DNA enables complex behaviour, including motility and information processing for adaptive and interactive processes. We chart future directions for DNA-empowered synthetic cells, envisioning interactive systems wherein synthetic cells communicate within communities and with living cells.

Identifiants

pubmed: 38750171
doi: 10.1038/s41570-024-00606-1
pii: 10.1038/s41570-024-00606-1
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2024. Springer Nature Limited.

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Auteurs

Avik Samanta (A)

Life-Like Materials and Systems, Department of Chemistry, University of Mainz, Mainz, Germany. avik.samanta@nt.iitr.ac.in.
Centre for Nanotechnology, Indian Institute of Technology Roorkee, Roorkee, India. avik.samanta@nt.iitr.ac.in.

Lorena Baranda Pellejero (L)

Life-Like Materials and Systems, Department of Chemistry, University of Mainz, Mainz, Germany.

Marcos Masukawa (M)

Life-Like Materials and Systems, Department of Chemistry, University of Mainz, Mainz, Germany.

Andreas Walther (A)

Life-Like Materials and Systems, Department of Chemistry, University of Mainz, Mainz, Germany. andreas.walther@uni-mainz.de.

Classifications MeSH