Shorter Peptide Nucleic Acid Probes Improve Affibody-Mediated Peptide Nucleic Acid-Based Pretargeting.


Journal

ACS pharmacology & translational science
ISSN: 2575-9108
Titre abrégé: ACS Pharmacol Transl Sci
Pays: United States
ID NLM: 101721411

Informations de publication

Date de publication:
10 May 2024
Historique:
received: 28 02 2024
revised: 28 03 2024
accepted: 10 04 2024
pmc-release: 29 04 2025
medline: 16 5 2024
pubmed: 16 5 2024
entrez: 16 5 2024
Statut: epublish

Résumé

Affibody-mediated PNA-based pretargeting shows promise for HER2-expressing tumor radiotherapy. In our recent study, a 15-mer Z

Identifiants

pubmed: 38751640
doi: 10.1021/acsptsci.4c00106
pmc: PMC11091976
doi:

Types de publication

Journal Article

Langues

eng

Pagination

1595-1611

Informations de copyright

© 2024 The Authors. Published by American Chemical Society.

Déclaration de conflit d'intérêts

The authors declare the following competing financial interest(s): KW, AV, AO, AEK and VT own shares in Zytox Therapeutics AB. MO is employed by Affibody AB. KW, HT and AEK are co-inventors of a patent application on PNA pretargeting (PCT/EP2021/078854). The other co-authors declare no competing interest.

Auteurs

Kristina Westerlund (K)

Department of Protein Science, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology, Stockholm 106 91, Sweden.

Maryam Oroujeni (M)

Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala 751 23, Sweden.
Affibody AB, Solna 171 65, Sweden.

Maxime Gestin (M)

Department of Protein Science, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology, Stockholm 106 91, Sweden.

Jacob Clinton (J)

Department of Protein Science, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology, Stockholm 106 91, Sweden.

Alia Hani Rosly (A)

Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala 751 23, Sweden.

Hanna Tano (H)

Department of Protein Science, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology, Stockholm 106 91, Sweden.

Anzhelika Vorobyeva (A)

Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala 751 23, Sweden.

Anna Orlova (A)

Department of Medicinal Chemistry, Uppsala University, Uppsala 751 23, Sweden.

Amelie Eriksson Karlström (A)

Department of Protein Science, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology, Stockholm 106 91, Sweden.

Vladimir Tolmachev (V)

Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala 751 23, Sweden.

Classifications MeSH