Insights into Mechanisms and Promising Triple Negative Breast Cancer Therapeutic Potential for a Water-Soluble Ruthenium Compound.

Journal

ACS pharmacology & translational science
ISSN: 2575-9108
Titre abrégé: ACS Pharmacol Transl Sci
Pays: United States
ID NLM: 101721411

Informations de publication

Date de publication:
10 May 2024
Historique:
received: 17 01 2024
revised: 14 03 2024
accepted: 22 03 2024
pmc-release: 05 04 2025
medline: 16 5 2024
pubmed: 16 5 2024
entrez: 16 5 2024
Statut: epublish

Résumé

Triple negative breast cancer (TNBC) represents a subtype of breast cancer that does not express the three major prognostic receptors of human epidermal growth factor receptor 2 (HER2), progesterone (PR), and estrogen (ER). This limits treatment options and results in a high rate of mortality. We have reported previously on the efficacy of a water-soluble, cationic organometallic compound (

Identifiants

DOI: 10.1021/acsptsci.4c00020 PMID: 38751641 PMC: PMC11092013
pubmed: 38751641
doi: 10.1021/acsptsci.4c00020
pmc: PMC11092013
doi:

Types de publication

Journal Article

Langues

eng

Pagination

1364-1376

Informations de copyright

© 2024 American Chemical Society.

Déclaration de conflit d'intérêts

The authors declare the following competing financial interest(s): The authors declare the following financial interests/personal relationships which may be considered as potential competing interests. Maria Contel has patent #US Patent 9555049 issued to Maria Contel, Isabel Marzo, Malgorzata Frik and Benelita T. Elie. Mark Bazett and Brian J Park are employees and/or stock holders of Bold Therapeutics Inc.

Auteurs

Nazia Nayeem (N)

Department of Chemistry, Brooklyn College, The City University of New York, Brooklyn, New York 11210, United States.
Brooklyn College Cancer Center, Brooklyn College, The City University of New York, Brooklyn, New York 11210, United States.
Biology PhD Program The Graduate Center, The City University of New York, New York, New York 10016, United States.

Sami Sauma (S)

Biology PhD Program The Graduate Center, The City University of New York, New York, New York 10016, United States.
Department of Biology, City College, The City University of New York, New York, New York 10031, United States.
Neuroscience Initiative, Advanced Science Research Center, New York, New York 10065, United States.

Afruja Ahad (A)

Department of Chemistry, Brooklyn College, The City University of New York, Brooklyn, New York 11210, United States.
Brooklyn College Cancer Center, Brooklyn College, The City University of New York, Brooklyn, New York 11210, United States.
Biology PhD Program The Graduate Center, The City University of New York, New York, New York 10016, United States.
Radiology, Memorial Sloan Kettering Cancer Center, New York, New York 10031, United States.
ORCID: 0009-0007-3887-9363

Rachele Rameau (R)

Biology PhD Program The Graduate Center, The City University of New York, New York, New York 10016, United States.
Department of Biology, City College, The City University of New York, New York, New York 10031, United States.

Sophia Kebadze (S)

Department of Chemistry, Brooklyn College, The City University of New York, Brooklyn, New York 11210, United States.
Brooklyn College Cancer Center, Brooklyn College, The City University of New York, Brooklyn, New York 11210, United States.

Mark Bazett (M)

Bold Therapeutics Inc., Vancouver, British Columbia V6C 1E1, Canada.

Brian J Park (BJ)

Bold Therapeutics Inc., Vancouver, British Columbia V6C 1E1, Canada.

Patrizia Casaccia (P)

Neuroscience Initiative, Advanced Science Research Center, New York, New York 10065, United States.

Swayam Prabha (S)

Fels Cancer Institute for Personalized Medicine and Department of Cancer and Cellular Biology, Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania 19104, United States.
Cancer Signaling and Tumor Microenvironment Program, Fox Chase Center, Temple University, Philadelphia, Pennsylvania 19111, United States.
ORCID: 0000-0001-6475-5494

Karen Hubbard (K)

Biology PhD Program The Graduate Center, The City University of New York, New York, New York 10016, United States.
Department of Biology, City College, The City University of New York, New York, New York 10031, United States.

Maria Contel (M)

Department of Chemistry, Brooklyn College, The City University of New York, Brooklyn, New York 11210, United States.
Brooklyn College Cancer Center, Brooklyn College, The City University of New York, Brooklyn, New York 11210, United States.
Biology PhD Program The Graduate Center, The City University of New York, New York, New York 10016, United States.
Chemistry PhD Program, The Graduate Center, The City University of New York, New York, New York 10016, United States.
Biochemistry PhD Program, The Graduate Center, The City University of New York, New York, New York 10016, United States.
ORCID: 0000-0002-9825-4441

Classifications MeSH