Essential role of N-terminal SAM regions in STIM1 multimerization and function.

Stromal Interaction Molecule 1 / metabolism Humans Protein Multimerization Neoplasm Proteins / metabolism Molecular Dynamics Simulation Endoplasmic Reticulum / metabolism Calcium / metabolism ORAI1 Protein / metabolism Protein Domains HEK293 Cells Binding Sites Protein Binding
EF-SAM Orai SOCE STIM

Journal

Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876

Informations de publication

Date de publication:
21 May 2024
Historique:
medline: 16 5 2024
pubmed: 16 5 2024
entrez: 16 5 2024
Statut: ppublish

Résumé

The single-pass transmembrane protein Stromal Interaction Molecule 1 (STIM1), located in the endoplasmic reticulum (ER) membrane, possesses two main functions: It senses the ER-Ca

Identifiants

DOI: 10.1073/pnas.2318874121 PMID: 38753510
pubmed: 38753510
doi: 10.1073/pnas.2318874121
doi:

Substances chimiques

STIM1 protein, human 0
ORAI1 protein, human 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e2318874121

Subventions

Organisme : Austrian Science Fund (FWF)
ID : P32778
Organisme : Austrian Science Fund (FWF)
ID : P32947
Organisme : Austrian Science Fund (FWF)
ID : T1190-B
Organisme : Austrian Science Fund (FWF)
ID : P33283
Organisme : Austrian Science Fund (FWF)
ID : P34884
Organisme : Canadian Government | Natural Sciences and Engineering Research Council of Canada (NSERC)
ID : 05239
Organisme : Czech Science Foundation
ID : 19-20728Y
Organisme : NIDCR-Division of Intramural Research
ID : Z01-DE00438-33

Déclaration de conflit d'intérêts

Competing interests statement:The authors declare no competing interest.

Auteurs

Matthias Sallinger (M)

Institute of Biophysics, Johannes Kepler University Linz, Linz 4040, Austria.
ORCID: 0000-0001-5225-8925

Christina Humer (C)

Institute of Biophysics, Johannes Kepler University Linz, Linz 4040, Austria.
ORCID: 0009-0004-2636-7705

Hwei Ling Ong (HL)

Secretory Physiology Section, National Institute of Dental and Craniofacial Research, NIH, Bethesda, MD 20892.
ORCID: 0000-0002-7551-6883

Sasirekha Narayanasamy (S)

Secretory Physiology Section, National Institute of Dental and Craniofacial Research, NIH, Bethesda, MD 20892.
ORCID: 0009-0008-5299-1906

Qi Tong Lin (QT)

Department of Physiology and Pharmacology, Western University, London, ON N6A5C1, Canada.
ORCID: 0000-0003-4636-6078

Marc Fahrner (M)

Institute of Biophysics, Johannes Kepler University Linz, Linz 4040, Austria.
ORCID: 0000-0002-2689-0158

Herwig Grabmayr (H)

Institute of Biophysics, Johannes Kepler University Linz, Linz 4040, Austria.
ORCID: 0000-0003-0870-5833

Sascha Berlansky (S)

Institute of Biophysics, Johannes Kepler University Linz, Linz 4040, Austria.

Sean Choi (S)

Secretory Physiology Section, National Institute of Dental and Craniofacial Research, NIH, Bethesda, MD 20892.
ORCID: 0009-0002-1328-9408

Tony Schmidt (T)

Department of Medical Physics and Biophysics, Medical University of Graz, Graz 8010, Austria.
ORCID: 0000-0001-8787-7363

Lena Maltan (L)

Institute of Biophysics, Johannes Kepler University Linz, Linz 4040, Austria.

Lara Atzgerstorfer (L)

Institute of Biophysics, Johannes Kepler University Linz, Linz 4040, Austria.

Martin Niederwieser (M)

Department of Medical Physics and Biophysics, Medical University of Graz, Graz 8010, Austria.
ORCID: 0009-0000-4724-2849

Irene Frischauf (I)

Institute of Biophysics, Johannes Kepler University Linz, Linz 4040, Austria.
ORCID: 0000-0003-0661-2932

Christoph Romanin (C)

Institute of Biophysics, Johannes Kepler University Linz, Linz 4040, Austria.
ORCID: 0000-0003-3756-4136

Peter B Stathopulos (PB)

Department of Physiology and Pharmacology, Western University, London, ON N6A5C1, Canada.
ORCID: 0000-0002-0536-6656

Indu Ambudkar (I)

Secretory Physiology Section, National Institute of Dental and Craniofacial Research, NIH, Bethesda, MD 20892.
ORCID: 0000-0002-9559-8679

Romana Leitner (R)

Institute of Biophysics, Johannes Kepler University Linz, Linz 4040, Austria.
ORCID: 0000-0002-9156-6266

Daniel Bonhenry (D)

Department of Physics and Materials Science, Faculty of Science, Technology and Medicine, University of Luxembourg, Esch-sur-Alzette L1511, Luxembourg.
ORCID: 0000-0002-6069-7642

Rainer Schindl (R)

Department of Medical Physics and Biophysics, Medical University of Graz, Graz 8010, Austria.
ORCID: 0000-0003-0896-8887

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Molécules d'interaction stromale › Molécule-1 d'interaction stromale › Essential role of N-terminal SAM regions in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Essential role of N-terminal SAM regions in...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Multimérisation de protéines › Essential role of N-terminal SAM regions in...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Essential role of N-terminal SAM regions in...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de dynamique moléculaire › Essential role of N-terminal SAM regions in...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Organites › Réticulum endoplasmique › Essential role of N-terminal SAM regions in...
questionsmedicales.fr › Facteurs biologiques › Facteurs de la coagulation sanguine › Calcium › Essential role of N-terminal SAM regions in...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Canaux ioniques › Canaux calciques › Canaux calciques activés par la libération de calcium › Protéine ORAI1 › Essential role of N-terminal SAM regions in...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Structure tertiaire des protéines › Domaines protéiques › Essential role of N-terminal SAM regions in...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules HEK293 › Essential role of N-terminal SAM regions in...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Sites de fixation › Essential role of N-terminal SAM regions in...
questionsmedicales.fr › Métabolisme › Liaison aux protéines › Essential role of N-terminal SAM regions in...