Synaptic Protein Loss in Extracellular Vesicles Reflects Brain and Retinal Atrophy in People With Multiple Sclerosis.

Humans Male Female Middle Aged Extracellular Vesicles / metabolism Adult Atrophy Brain / pathology Retina / pathology Multiple Sclerosis / pathology Synaptophysin / metabolism Tomography, Optical Coherence Magnetic Resonance Imaging Microfilament Proteins / metabolism

Journal

Neurology(R) neuroimmunology & neuroinflammation
ISSN: 2332-7812
Titre abrégé: Neurol Neuroimmunol Neuroinflamm
Pays: United States
ID NLM: 101636388

Informations de publication

Date de publication:
Jul 2024
Historique:
medline: 16 5 2024
pubmed: 16 5 2024
entrez: 16 5 2024
Statut: ppublish

Résumé

To assess whether the rate of change in synaptic proteins isolated from neuronally enriched extracellular vesicles (NEVs) is associated with brain and retinal atrophy in people with multiple sclerosis (MS). People with MS were followed with serial blood draws, MRI (MRI), and optical coherence tomography (OCT) scans. NEVs were immunocaptured from plasma, and synaptopodin and synaptophysin proteins were measured using ELISA. Subject-specific rates of change in synaptic proteins, as well as brain and retinal atrophy, were determined and correlated. A total of 50 people with MS were included, 46 of whom had MRI and 45 had OCT serially. The rate of change in NEV synaptopodin was associated with whole brain (rho = 0.31; NEV-derived synaptic proteins likely reflect neurodegeneration and may provide additional circulating biomarkers for disease progression in MS.

Identifiants

DOI: 10.1212/NXI.0000000000200257 PMID: 38754047
pubmed: 38754047
doi: 10.1212/NXI.0000000000200257
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e200257

Auteurs

Dimitrios C Ladakis (DC)

From the Department of Neurology (D.C.L., K.L.H., M.D.S., E.S.V., H.M., G.A., O.E., A.L.D., B.E.D., K.C.F., E.S.S., S.S., P.A.C., P.B.), Johns Hopkins University School of Medicine; Laboratory of Clinical Investigation (M.V., J.B., D.K.), National Institute on Aging; and Department of Electrical and Computer Engineering (J.L.P.), Johns Hopkins University, Baltimore, MD.
ORCID: 0000-0002-5764-2114

Michael Vreones (M)

From the Department of Neurology (D.C.L., K.L.H., M.D.S., E.S.V., H.M., G.A., O.E., A.L.D., B.E.D., K.C.F., E.S.S., S.S., P.A.C., P.B.), Johns Hopkins University School of Medicine; Laboratory of Clinical Investigation (M.V., J.B., D.K.), National Institute on Aging; and Department of Electrical and Computer Engineering (J.L.P.), Johns Hopkins University, Baltimore, MD.
ORCID: 0009-0003-1719-8156

Joseph Blommer (J)

From the Department of Neurology (D.C.L., K.L.H., M.D.S., E.S.V., H.M., G.A., O.E., A.L.D., B.E.D., K.C.F., E.S.S., S.S., P.A.C., P.B.), Johns Hopkins University School of Medicine; Laboratory of Clinical Investigation (M.V., J.B., D.K.), National Institute on Aging; and Department of Electrical and Computer Engineering (J.L.P.), Johns Hopkins University, Baltimore, MD.
ORCID: 0000-0002-5551-9219

Kimystian L Harrison (KL)

From the Department of Neurology (D.C.L., K.L.H., M.D.S., E.S.V., H.M., G.A., O.E., A.L.D., B.E.D., K.C.F., E.S.S., S.S., P.A.C., P.B.), Johns Hopkins University School of Medicine; Laboratory of Clinical Investigation (M.V., J.B., D.K.), National Institute on Aging; and Department of Electrical and Computer Engineering (J.L.P.), Johns Hopkins University, Baltimore, MD.
ORCID: 0000-0003-2841-2800

Matthew D Smith (MD)

From the Department of Neurology (D.C.L., K.L.H., M.D.S., E.S.V., H.M., G.A., O.E., A.L.D., B.E.D., K.C.F., E.S.S., S.S., P.A.C., P.B.), Johns Hopkins University School of Medicine; Laboratory of Clinical Investigation (M.V., J.B., D.K.), National Institute on Aging; and Department of Electrical and Computer Engineering (J.L.P.), Johns Hopkins University, Baltimore, MD.
ORCID: 0000-0001-6614-569X

Eleni S Vasileiou (ES)

From the Department of Neurology (D.C.L., K.L.H., M.D.S., E.S.V., H.M., G.A., O.E., A.L.D., B.E.D., K.C.F., E.S.S., S.S., P.A.C., P.B.), Johns Hopkins University School of Medicine; Laboratory of Clinical Investigation (M.V., J.B., D.K.), National Institute on Aging; and Department of Electrical and Computer Engineering (J.L.P.), Johns Hopkins University, Baltimore, MD.
ORCID: 0000-0002-8639-8405

Hussein Moussa (H)

From the Department of Neurology (D.C.L., K.L.H., M.D.S., E.S.V., H.M., G.A., O.E., A.L.D., B.E.D., K.C.F., E.S.S., S.S., P.A.C., P.B.), Johns Hopkins University School of Medicine; Laboratory of Clinical Investigation (M.V., J.B., D.K.), National Institute on Aging; and Department of Electrical and Computer Engineering (J.L.P.), Johns Hopkins University, Baltimore, MD.

Gelareh Ahmadi (G)

From the Department of Neurology (D.C.L., K.L.H., M.D.S., E.S.V., H.M., G.A., O.E., A.L.D., B.E.D., K.C.F., E.S.S., S.S., P.A.C., P.B.), Johns Hopkins University School of Medicine; Laboratory of Clinical Investigation (M.V., J.B., D.K.), National Institute on Aging; and Department of Electrical and Computer Engineering (J.L.P.), Johns Hopkins University, Baltimore, MD.

Omar Ezzedin (O)

From the Department of Neurology (D.C.L., K.L.H., M.D.S., E.S.V., H.M., G.A., O.E., A.L.D., B.E.D., K.C.F., E.S.S., S.S., P.A.C., P.B.), Johns Hopkins University School of Medicine; Laboratory of Clinical Investigation (M.V., J.B., D.K.), National Institute on Aging; and Department of Electrical and Computer Engineering (J.L.P.), Johns Hopkins University, Baltimore, MD.

Anna L DuVal (AL)

From the Department of Neurology (D.C.L., K.L.H., M.D.S., E.S.V., H.M., G.A., O.E., A.L.D., B.E.D., K.C.F., E.S.S., S.S., P.A.C., P.B.), Johns Hopkins University School of Medicine; Laboratory of Clinical Investigation (M.V., J.B., D.K.), National Institute on Aging; and Department of Electrical and Computer Engineering (J.L.P.), Johns Hopkins University, Baltimore, MD.
ORCID: 0000-0003-3520-5631

Blake E Dewey (BE)

From the Department of Neurology (D.C.L., K.L.H., M.D.S., E.S.V., H.M., G.A., O.E., A.L.D., B.E.D., K.C.F., E.S.S., S.S., P.A.C., P.B.), Johns Hopkins University School of Medicine; Laboratory of Clinical Investigation (M.V., J.B., D.K.), National Institute on Aging; and Department of Electrical and Computer Engineering (J.L.P.), Johns Hopkins University, Baltimore, MD.
ORCID: 0000-0003-4554-5058

Jerry L Prince (JL)

From the Department of Neurology (D.C.L., K.L.H., M.D.S., E.S.V., H.M., G.A., O.E., A.L.D., B.E.D., K.C.F., E.S.S., S.S., P.A.C., P.B.), Johns Hopkins University School of Medicine; Laboratory of Clinical Investigation (M.V., J.B., D.K.), National Institute on Aging; and Department of Electrical and Computer Engineering (J.L.P.), Johns Hopkins University, Baltimore, MD.

Kathryn C Fitzgerald (KC)

From the Department of Neurology (D.C.L., K.L.H., M.D.S., E.S.V., H.M., G.A., O.E., A.L.D., B.E.D., K.C.F., E.S.S., S.S., P.A.C., P.B.), Johns Hopkins University School of Medicine; Laboratory of Clinical Investigation (M.V., J.B., D.K.), National Institute on Aging; and Department of Electrical and Computer Engineering (J.L.P.), Johns Hopkins University, Baltimore, MD.
ORCID: 0000-0003-3137-0322

Elias S Sotirchos (ES)

From the Department of Neurology (D.C.L., K.L.H., M.D.S., E.S.V., H.M., G.A., O.E., A.L.D., B.E.D., K.C.F., E.S.S., S.S., P.A.C., P.B.), Johns Hopkins University School of Medicine; Laboratory of Clinical Investigation (M.V., J.B., D.K.), National Institute on Aging; and Department of Electrical and Computer Engineering (J.L.P.), Johns Hopkins University, Baltimore, MD.
ORCID: 0000-0002-8812-1637

Shiv Saidha (S)

From the Department of Neurology (D.C.L., K.L.H., M.D.S., E.S.V., H.M., G.A., O.E., A.L.D., B.E.D., K.C.F., E.S.S., S.S., P.A.C., P.B.), Johns Hopkins University School of Medicine; Laboratory of Clinical Investigation (M.V., J.B., D.K.), National Institute on Aging; and Department of Electrical and Computer Engineering (J.L.P.), Johns Hopkins University, Baltimore, MD.
ORCID: 0000-0001-6387-0714

Peter A Calabresi (PA)

From the Department of Neurology (D.C.L., K.L.H., M.D.S., E.S.V., H.M., G.A., O.E., A.L.D., B.E.D., K.C.F., E.S.S., S.S., P.A.C., P.B.), Johns Hopkins University School of Medicine; Laboratory of Clinical Investigation (M.V., J.B., D.K.), National Institute on Aging; and Department of Electrical and Computer Engineering (J.L.P.), Johns Hopkins University, Baltimore, MD.
ORCID: 0000-0002-7776-6472

Dimitrios Kapogiannis (D)

From the Department of Neurology (D.C.L., K.L.H., M.D.S., E.S.V., H.M., G.A., O.E., A.L.D., B.E.D., K.C.F., E.S.S., S.S., P.A.C., P.B.), Johns Hopkins University School of Medicine; Laboratory of Clinical Investigation (M.V., J.B., D.K.), National Institute on Aging; and Department of Electrical and Computer Engineering (J.L.P.), Johns Hopkins University, Baltimore, MD.
ORCID: 0000-0003-2181-3118

Pavan Bhargava (P)

From the Department of Neurology (D.C.L., K.L.H., M.D.S., E.S.V., H.M., G.A., O.E., A.L.D., B.E.D., K.C.F., E.S.S., S.S., P.A.C., P.B.), Johns Hopkins University School of Medicine; Laboratory of Clinical Investigation (M.V., J.B., D.K.), National Institute on Aging; and Department of Electrical and Computer Engineering (J.L.P.), Johns Hopkins University, Baltimore, MD.
ORCID: 0000-0002-7947-9418

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Synaptic Protein Loss in Extracellular...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Synaptic Protein Loss in Extracellular...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace extracellulaire › Vésicules extracellulaires › Synaptic Protein Loss in Extracellular...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Synaptic Protein Loss in Extracellular...
questionsmedicales.fr › États, signes et symptômes pathologiques › États anatomopathologiques › Atrophie › Synaptic Protein Loss in Extracellular...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Synaptic Protein Loss in Extracellular...
questionsmedicales.fr › Organes des sens › Oeil › Rétine › Synaptic Protein Loss in Extracellular...
questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Maladies auto-immunes du système nerveux › Maladies démyélinisantes auto-immunes du SNC › Sclérose en plaques › Synaptic Protein Loss in Extracellular...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Marqueurs biologiques tumoraux › Synaptophysine › Synaptic Protein Loss in Extracellular...
questionsmedicales.fr › Techniques d'investigation › Imagerie optique › Tomographie optique › Tomographie par cohérence optique › Synaptic Protein Loss in Extracellular...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Imagerie par résonance magnétique › Synaptic Protein Loss in Extracellular...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du cytosquelette › Protéines des microfilaments › Synaptic Protein Loss in Extracellular...