Total body irradiation versus thiotepa/busulfan-based conditioning regimens for myeloablative allogeneic stem cell transplantation in adults with acute lymphoblastic leukemia.


Journal

Bone marrow transplantation
ISSN: 1476-5365
Titre abrégé: Bone Marrow Transplant
Pays: England
ID NLM: 8702459

Informations de publication

Date de publication:
16 May 2024
Historique:
received: 07 02 2024
accepted: 24 04 2024
revised: 22 04 2024
medline: 17 5 2024
pubmed: 17 5 2024
entrez: 16 5 2024
Statut: aheadofprint

Résumé

Total body irradiation (TBI)-based conditioning regimens are generally recommended for allogeneic HSCT (allo-HSCT) in patients with acute lymphoblastic leukemia (ALL). Recent evidence suggests that modern chemotherapy-based regimens may be as effective. This multicenter retrospective study compared the clinical outcomes of myeloablative allo-HSCT with thiotepa, busulfan, and cyclophosphamide/fludarabine (TTB) to TBI-based conditioning. Between 2002 to 2018, 63 and 114 patients received TTB- and TBI-based conditioning regimens, respectively. The 5-year cumulative incidence of relapse was lower in the TBI cohort compared to the TTB cohort (30% [95% CI, 22-38] versus 47% [95% CI, 36-59]; P = 0.03). Multivariate analysis identified T-ALL, Ph-negative B-ALL, and measurable residual disease associated with a higher relapse risk. The 5-year cumulative incidence of non-relapsed mortality (NRM) was significantly lower with TTB (12% [95% CI, 5-20]) compared to TBI (25% [95% CI, 18-33]) (P = 0.001). Multivariate analysis found TBI conditioning, older age, and advanced stages of ALL at transplantation associated with a higher NRM. No statistical difference was seen in overall survival (49% [95% CI, 40-58] and 46% [95% CI, 35-60]) in the TBI and TTB groups, respectively; P = 0.9). The study suggests that TTB-based conditioning may be a promising option for ALL patients undergoing allo-HSCT, as it resulted in similar OS and lower NRM than TBI-based conditioning.

Identifiants

pubmed: 38755458
doi: 10.1038/s41409-024-02298-z
pii: 10.1038/s41409-024-02298-z
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2024. The Author(s), under exclusive licence to Springer Nature Limited.

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Auteurs

Elvira Mora (E)

Hematology Department, Hospital Universitario y Politécnico La Fe, Valencia, Spain. mora_elv@gva.es.
Instituto de Investigación Sanitaria La Fe, Valencia, Spain. mora_elv@gva.es.

Juan Montoro (J)

Hematology Department, Hospital Universitario y Politécnico La Fe, Valencia, Spain.
Instituto de Investigación Sanitaria La Fe, Valencia, Spain.

Aitana Balaguer (A)

Hematology Department, Hospital Universitario y Politécnico La Fe, Valencia, Spain.
Instituto de Investigación Sanitaria La Fe, Valencia, Spain.
Centro de Investigación Biomédica en Red de Cáncer, Instituto Carlos III, Madrid, Spain.

Montserrat Rovira (M)

BMT Unit. Hematology Department, ICMHO, Hospital Clínic, Institut Josep Carreras contra la leucemia, Barcelona, Spain.

Monica Cabrero (M)

Hematology Department, Hospital Universitario de Salamanca, Salamanca, Spain.
Instituto de Investigación Biomedica de Salamanca-IBSAL, Salamanca, Spain.

Inmaculada Heras (I)

Hematology Department, Hospital General Universitario Morales Meseguer, Murcia, Spain.

Josep-Maria Ribera (JM)

Hematology Department. Institut Català d'Oncologia - Hospital Germans Trias i Pujol, Josep Carreras Research Institute, Badalona, Spain.
Department of Medicine, Universidad Autónoma de Barcelona, Badalona, Spain.

Gabriela Antelo (G)

Radiation Oncology Department, ICMHO, Hospital Clínic, Barcelona, Spain.

Ana Africa Martin (AA)

Hematology Department, Hospital Universitario de Salamanca, Salamanca, Spain.
Instituto de Investigación Biomedica de Salamanca-IBSAL, Salamanca, Spain.

Oriana Lopez Godino (O)

Hematology Department, Hospital General Universitario Morales Meseguer, Murcia, Spain.

Anna Torrent (A)

Hematology Department. Institut Català d'Oncologia - Hospital Germans Trias i Pujol, Josep Carreras Research Institute, Badalona, Spain.

Marta Villalba (M)

Hematology Department, Hospital Universitario y Politécnico La Fe, Valencia, Spain.
Instituto de Investigación Sanitaria La Fe, Valencia, Spain.

Pedro Chorao (P)

Hematology Department, Hospital Universitario y Politécnico La Fe, Valencia, Spain.
Instituto de Investigación Sanitaria La Fe, Valencia, Spain.

Miguel A Sanz (MA)

Hematology Department, Hospital Universitario y Politécnico La Fe, Valencia, Spain.
Instituto de Investigación Sanitaria La Fe, Valencia, Spain.
Department of Medicine, University of Valencia, Valencia, Spain.

Jaime Sanz (J)

Hematology Department, Hospital Universitario y Politécnico La Fe, Valencia, Spain.
Instituto de Investigación Sanitaria La Fe, Valencia, Spain.
Centro de Investigación Biomédica en Red de Cáncer, Instituto Carlos III, Madrid, Spain.
Department of Medicine, University of Valencia, Valencia, Spain.

Classifications MeSH