Quantitative analysis of similarity between cerebral arterial blood volume and intracranial pressure pulse waveforms during intracranial pressure plateau waves.

Both intracranial pressure (ICP) and cerebral arterial blood volume (C Does ICP pulse waveform become similar to non-invasively estimated C A total of 15 plateau waves recorded in 15 traumatic brain injured patients were analyzed. C ICP increased (19.4 mm Hg [Q1-Q3: 18.2-23.4 mm Hg] vs. 42.7 mm Hg [Q1-Q3: 36.5-45.1 mm Hg], p < 0.001) while CBFV decreased (44.2 cm/s [Q1-Q3: 34.8-69.5 cm/s] vs. 32.9 cm/s [Q1-Q3: 24.7-68.2 cm/s], p = 0.002) during plateau waves. DI was smaller during the plateau waves (20.4 [Q1-Q3: 15.74-23.0]) compared to the baselines (26.3 [Q1-Q3: 24.2-34.7], p < 0.001). The area between corresponding ICP and C

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The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Arkadiusz Ziolkowski reports financial support was provided by National Science Centre Poland. Magdalena Kasprowicz reports financial support was provided by National Science Centre Poland. Agnieszka Kazimierska reports financial support was provided by National Science Centre Poland. Marek Czosnyka reports financial support was provided by European Regional Development Fund. Marek Czosnyka reports support was provided by National Institute for Health and Care Research , Cambridge. Marek Czosnyka has patent licensed to Part of the licensing fee of ICM + software.