Plant-derived exosome-like nanoparticles for microRNA delivery in cancer treatment.

Cancer treatment Cross-kingdom regulation Inflammation Intestinal homeostasis Plant-derived exosome-like nanoparticles miRNA delivery systems

Journal

Drug delivery and translational research
ISSN: 2190-3948
Titre abrégé: Drug Deliv Transl Res
Pays: United States
ID NLM: 101540061

Informations de publication

Date de publication:
17 May 2024
Historique:
accepted: 05 05 2024
medline: 17 5 2024
pubmed: 17 5 2024
entrez: 17 5 2024
Statut: aheadofprint

Résumé

Plant-derived exosome-like nanoparticles (PELNs) are natural nanocarriers and effective delivery systems for plant microRNAs (miRNAs). These PELN-carrying plant miRNAs can regulate mammalian genes across species, thereby increasing the diversity of miRNAs in mammals and exerting multi-target effects that play a crucial role in diseases, particularly cancer. PELNs demonstrate exceptional stability, biocompatibility, and targeting capabilities that protect and facilitate the up-take and cross-kingdom communication of plant miRNAs in mammals. Primarily ingested and absorbed within the gastrointestinal tract of mammals, PELNs preferentially act on the intestine to regulate intestinal homeostasis through functional miRNA activity. The oncogenesis and progression of cancer are closely associated with disruptions in intestinal barriers, ecological imbalances, as well as secondary changes, such as abnormal inflammatory reactions caused by them. Therefore, it is imperative to investigate whether PELNs exert their anticancer effects by regulating mammalian intestinal homeostasis and inflammation. This review aims to elucidate the intrinsic crosstalk relationships and mechanisms of PELNs-mediated miRNAs in maintaining intestinal homeostasis, regulating inflammation and cancer treatment. Furthermore, serving as exceptional drug delivery systems for miRNAs molecules, PELNs offer broad prospects for future applications, including new drug research and development along with drug carrier selection within targeted drug delivery approaches for cancer therapy.

Identifiants

pubmed: 38758499
doi: 10.1007/s13346-024-01621-x
pii: 10.1007/s13346-024-01621-x
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : National Natural Science Foundation of China
ID : 82074450
Organisme : Key Scientific Research Project of Hunan Education Department
ID : 21A0243
Organisme : Key Project of Academician Workstation Guidance Project
ID : 22YS002
Organisme : Key Projects of First-class Discipline of Integrated Traditional Chinese and Western Medicine
ID : 2021ZXYJH11
Organisme : National Natural Science Foundation of Changsha City
ID : kq2202271

Informations de copyright

© 2024. Controlled Release Society.

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Auteurs

Chun Yi (C)

Department of Pathology, Faculty of Medicine, Hunan University of Chinese Medicine, 410208, Changsha, Hunan, China.

Linzhu Lu (L)

College of Integrated Chinese and Western Medicine, Hunan University of Chinese Medicine, 300 Xueshi Road, Yuelu District, 410208, Changsha, Hunan Province, China.

Zhaosheng Li (Z)

College of Integrated Chinese and Western Medicine, Hunan University of Chinese Medicine, 300 Xueshi Road, Yuelu District, 410208, Changsha, Hunan Province, China.

Qianqian Guo (Q)

College of Integrated Chinese and Western Medicine, Hunan University of Chinese Medicine, 300 Xueshi Road, Yuelu District, 410208, Changsha, Hunan Province, China.

Longyun Ou (L)

The First Hospital of Hunan University of Chinese Medicine, 410208, Changsha, Hunan, China.

Ruoyu Wang (R)

Department of Infectious Diseases, Department of Liver Diseases, The First Hospital of Hunan University of Chinese Medicine, 95 Shaoshan Rd, Hunan, 410208, Changsha, China. wrysky@live.com.

Xuefei Tian (X)

College of Integrated Chinese and Western Medicine, Hunan University of Chinese Medicine, 300 Xueshi Road, Yuelu District, 410208, Changsha, Hunan Province, China. 003640@hnucm.edu.cn.
Hunan Province University Key Laboratory of Oncology of Tradional Chinese Medicine, 410208, Changsha, Hunan, China. 003640@hnucm.edu.cn.

Classifications MeSH