Role of amelogenin phosphorylation in regulating dental enamel formation.

Acidification amelogenesis amelogenin biomineralization enamel protein phosphorylation

Journal

Matrix biology : journal of the International Society for Matrix Biology
ISSN: 1569-1802
Titre abrégé: Matrix Biol
Pays: Netherlands
ID NLM: 9432592

Informations de publication

Date de publication:
15 May 2024
Historique:
received: 21 03 2024
revised: 08 05 2024
accepted: 14 05 2024
medline: 18 5 2024
pubmed: 18 5 2024
entrez: 17 5 2024
Statut: aheadofprint

Résumé

Amelogenin (AMELX), the predominant matrix protein in enamel formation, contains a singular phosphorylation site at Serine 16 (S16) that greatly enhances AMELX's capacity to stabilize amorphous calcium phosphate (ACP) and inhibit its transformation to apatitic enamel crystals. To explore the potential role of AMELX phosphorylation in vivo, we developed a knock-in (KI) mouse model in which AMELX phosphorylation is prevented by substituting S16 with Ala (A). As anticipated, AMELX

Identifiants

DOI: 10.1016/j.matbio.2024.05.004 PMID: 38759902
pubmed: 38759902
pii: S0945-053X(24)00065-9
doi: 10.1016/j.matbio.2024.05.004
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

Copyright © 2024. Published by Elsevier B.V.

Auteurs

Claire Gabe (C)

Department of Oral and Craniofacial Sciences, University of Pittsburgh School of Dental Medicine, 335 Sutherland Drive (UPSDM), Pittsburgh, PA 15260, USA; Center for Craniofacial Regeneration, UPSDM, Pittsburgh, PA, USA.

Ai Thu Bui (AT)

Department of Oral and Craniofacial Sciences, University of Pittsburgh School of Dental Medicine, 335 Sutherland Drive (UPSDM), Pittsburgh, PA 15260, USA; Center for Craniofacial Regeneration, UPSDM, Pittsburgh, PA, USA.

Lyudmila Lukashova (L)

Department of Endodontics, UPSDM, Pittsburgh, PA, USA.

Kostas Verdelis (K)

Center for Craniofacial Regeneration, UPSDM, Pittsburgh, PA, USA; Department of Endodontics, UPSDM, Pittsburgh, PA, USA.

Brent Vasquez (B)

Department of Oral and Craniofacial Sciences, University of Pittsburgh School of Dental Medicine, 335 Sutherland Drive (UPSDM), Pittsburgh, PA 15260, USA; Center for Craniofacial Regeneration, UPSDM, Pittsburgh, PA, USA.

Elia Beniash (E)

Department of Oral and Craniofacial Sciences, University of Pittsburgh School of Dental Medicine, 335 Sutherland Drive (UPSDM), Pittsburgh, PA 15260, USA; Center for Craniofacial Regeneration, UPSDM, Pittsburgh, PA, USA.

Henry C Margolis (HC)

Department of Oral and Craniofacial Sciences, University of Pittsburgh School of Dental Medicine, 335 Sutherland Drive (UPSDM), Pittsburgh, PA 15260, USA; Center for Craniofacial Regeneration, UPSDM, Pittsburgh, PA, USA; Department of Periodontics and Preventive Dentistry, UPSDM, Pittsburgh, PA, USA. Electronic address: hmargolis@pitt.edu.

Classifications MeSH