Elimination of damaged mitochondria during UVB-induced senescence is orchestrated by NIX-dependent mitophagy.
NIX
UVB
mitochondria
mitophagy
senescence
skin aging
vesicles
Journal
Aging cell
ISSN: 1474-9726
Titre abrégé: Aging Cell
Pays: England
ID NLM: 101130839
Informations de publication
Date de publication:
17 May 2024
17 May 2024
Historique:
revised:
12
04
2024
received:
16
08
2021
accepted:
17
04
2024
medline:
18
5
2024
pubmed:
18
5
2024
entrez:
18
5
2024
Statut:
aheadofprint
Résumé
Skin aging is the result of two types of aging, "intrinsic aging" an inevitable consequence of physiologic and genetically determined changes and "extrinsic aging," which is dependent on external factors such as exposure to sunlight, smoking, and dietary habits. UVB causes skin injury through the generation of free radicals and other oxidative byproducts, also contributing to DNA damage. Appearance and accumulation of senescent cells in the skin are considered one of the hallmarks of aging in this tissue. Mitochondria play an important role for the development of cellular senescence, in particular stress-induced senescence of human cells. However, many aspects of mitochondrial physiology relevant to cellular senescence and extrinsic skin aging remain to be unraveled. Here, we demonstrate that mitochondria damaged by UVB irradiation of human dermal fibroblasts (HDF) are eliminated by NIX-dependent mitophagy and that this process is important for cell survival under these conditions. Additionally, UVB-irradiation of human dermal fibroblasts (HDF) induces the shedding of extracellular vesicles (EVs), and this process is significantly enhanced in UVB-irradiated NIX-depleted cells. Our findings establish NIX as the main mitophagy receptor in the process of UVB-induced senescence and suggest the release of EVs as an alternative mechanism of mitochondrial quality control in HDF.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e14186Subventions
Organisme : Tiroler Wissenschaftsförderung
ID : F.33287/10-2021
Organisme : Tiroler Wissenschaftsförderung
ID : ZAP46010
Organisme : Conselho Nacional de Desenvolvimento Científico e Tecnológico
ID : 201892/2012-0
Organisme : Austrian Science Fund
ID : FG2400B
Organisme : Austrian Science Fund
ID : P-315820
Organisme : University of Innsbruck
Informations de copyright
© 2024 The Authors. Aging Cell published by Anatomical Society and John Wiley & Sons Ltd.
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