Antiepileptic drug-loaded and multifunctional iron oxide@silica@gelatin nanoparticles for acid-triggered drug delivery.
Gelatin
/ chemistry
Anticonvulsants
/ chemistry
Silicon Dioxide
/ chemistry
Hydrogen-Ion Concentration
Phenytoin
/ chemistry
Drug Delivery Systems
/ methods
Humans
Ferric Compounds
/ chemistry
Drug Liberation
Drug Carriers
/ chemistry
Magnetic Iron Oxide Nanoparticles
/ chemistry
Magnetite Nanoparticles
/ chemistry
Nanoparticles
/ chemistry
Particle Size
Antiepileptic drug
Drug delivery
Gelatin
Phenytoin
Silica
Superparamagnetic nanoparticles
pH-sensitivity
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
18 May 2024
18 May 2024
Historique:
received:
16
11
2023
accepted:
15
05
2024
medline:
19
5
2024
pubmed:
19
5
2024
entrez:
18
5
2024
Statut:
epublish
Résumé
The current study developed an innovative design for the production of smart multifunctional core-double shell superparamagnetic nanoparticles (NPs) with a focus on the development of a pH-responsive drug delivery system tailored for the controlled release of Phenytoin, accompanied by real-time monitoring capabilities. In this regard, the ultra-small superparamagnetic iron oxide@silica NPs (IO@Si MNPs) were synthesized and then coated with a layer of gelatin containing Phenytoin as an antiepileptic drug. The precise saturation magnetization value for the resultant NPs was established at 26 emu g
Identifiants
pubmed: 38762571
doi: 10.1038/s41598-024-62248-z
pii: 10.1038/s41598-024-62248-z
doi:
Substances chimiques
ferric oxide
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
11400Informations de copyright
© 2024. The Author(s).
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