Optimizing resource allocation: Cost-effectiveness of specified D-dimer cut-offs in cancer patients with suspected venous thromboembolism.

Cancer Cost-effectiveness analysis D-dimer Deep vein thrombosis Pulmonary embolism Venous thromboembolism

Journal

Journal of thrombosis and thrombolysis
ISSN: 1573-742X
Titre abrégé: J Thromb Thrombolysis
Pays: Netherlands
ID NLM: 9502018

Informations de publication

Date de publication:
18 May 2024
Historique:
accepted: 05 05 2024
medline: 19 5 2024
pubmed: 19 5 2024
entrez: 18 5 2024
Statut: aheadofprint

Résumé

An accurate diagnosis of venous thromboembolism (VTE) is crucial, given the potential for high mortality in undetected cases. Strategic D-dimer testing may aid in identifying low-risk patients, preventing overdiagnosis and reducing imaging costs. We conducted a retrospective, comparative analysis to assess the potential cost savings that could be achieved by adopting different approaches to determine the most effective D-dimer cut-off value in cancer patients with suspected VTE, compared to the commonly used rule-out cut-off level of 0.5 mg/L. The study included 526 patients (median age 65, IQR 55-75) with a confirmed cancer diagnosis who underwent D-dimer testing. Among these patients, the VTE prevalence was 29% (n = 152). Each diagnostic strategy's sensitivity, specificity, negative likelihood ratio (NLR), as well as positive likelihood ratio (PLR), and the proportion of patients exhibiting a negative D-dimer test result, were calculated. The diagnostic strategy that demonstrated the best balance between specificity, sensitivity, NLR, and PLR, utilized an inverse age-specific cut-off level for D-dimer [0.5 + (66-age) × 0.01 mg/L]. This method yielded a PLR of 2.9 at a very low NLR for the exclusion of VTE. We observed a significant cost reduction of 4.6% and 1.0% for PE and DVT, respectively. The utilization of an age-adjusted cut-off [patient's age × 0.01 mg/L] resulted in the highest cost savings, reaching 8.1% for PE and 3.4% for DVT. Using specified D-dimer cut-offs in the diagnosis of VTE could improve economics, considering the limited occurrence of confirmed cases among patients with suspected VTE.

Identifiants

pubmed: 38762707
doi: 10.1007/s11239-024-03000-2
pii: 10.1007/s11239-024-03000-2
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2024. The Author(s).

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Auteurs

Teodora Biciusca (T)

Department of Diagnostic and Interventional Radiology, Goethe University Frankfurt, University Hospital, Frankfurt Am Main, Germany. teodorabiciusca96@gmail.com.

Leon D Gruenewald (LD)

Department of Diagnostic and Interventional Radiology, Goethe University Frankfurt, University Hospital, Frankfurt Am Main, Germany.

Simon S Martin (SS)

Department of Diagnostic and Interventional Radiology, Goethe University Frankfurt, University Hospital, Frankfurt Am Main, Germany.

Jennifer Gotta (J)

Department of Diagnostic and Interventional Radiology, Goethe University Frankfurt, University Hospital, Frankfurt Am Main, Germany.

Scherwin Mahmoudi (S)

Department of Diagnostic and Interventional Radiology, Goethe University Frankfurt, University Hospital, Frankfurt Am Main, Germany.

Katrin Eichler (K)

Department of Diagnostic and Interventional Radiology, Goethe University Frankfurt, University Hospital, Frankfurt Am Main, Germany.

Christian Booz (C)

Department of Diagnostic and Interventional Radiology, Goethe University Frankfurt, University Hospital, Frankfurt Am Main, Germany.

Christian Salbach (C)

Department of Cardiology, Angiology, and Pulmonology, University of Heidelberg, University Hospital, Heidelberg, Germany.

Matthias Müller-Hennessen (M)

Department of Cardiology, Angiology, and Pulmonology, University of Heidelberg, University Hospital, Heidelberg, Germany.

Moritz Biener (M)

Department of Cardiology, Angiology, and Pulmonology, University of Heidelberg, University Hospital, Heidelberg, Germany.

Mustafa Yildirim (M)

Department of Cardiology, Angiology, and Pulmonology, University of Heidelberg, University Hospital, Heidelberg, Germany.

Barbara Milles (B)

Department of Cardiology, Angiology, and Pulmonology, University of Heidelberg, University Hospital, Heidelberg, Germany.

Christof M Sommer (CM)

Department of Diagnostic and Interventional Radiology, University of Heidelberg, University Hospital, Heidelberg, Germany.

Thomas J Vogl (TJ)

Department of Diagnostic and Interventional Radiology, Goethe University Frankfurt, University Hospital, Frankfurt Am Main, Germany.

Evangelos Giannitsis (E)

Department of Cardiology, Angiology, and Pulmonology, University of Heidelberg, University Hospital, Heidelberg, Germany.

Vitali Koch (V)

Department of Diagnostic and Interventional Radiology, Goethe University Frankfurt, University Hospital, Frankfurt Am Main, Germany.
Department of Cardiology, Angiology, and Pulmonology, University of Heidelberg, University Hospital, Heidelberg, Germany.

Classifications MeSH