Piperine enhances contractile force in slow- and fast-twitch muscle.
Ca2+ release
force potentiation
muscle contraction
prolonged low‐frequency force depression
Journal
The Journal of physiology
ISSN: 1469-7793
Titre abrégé: J Physiol
Pays: England
ID NLM: 0266262
Informations de publication
Date de publication:
19 May 2024
19 May 2024
Historique:
received:
05
12
2023
accepted:
30
04
2024
medline:
19
5
2024
pubmed:
19
5
2024
entrez:
19
5
2024
Statut:
aheadofprint
Résumé
Piperine has been shown to bind to myosin and shift the distribution of conformational states of myosin molecules from the super-relaxed state to the disordered relaxed state. However, little is known about the implications for muscle force production and potential underlying mechanisms. Muscle contractility experiments were performed using isolated muscles and single fibres from rats and mice. The dose-response effect of piperine on muscle force was assessed at several stimulation frequencies. The potentiation of muscle force was also tested in muscles fatigued by eccentric contractions. Potential mechanisms of force potentiation were assessed by measuring Ca
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Natural Sciences and Engineering Research Council of Canada - Discovery Grant
ID : RGPIN-2020-06443
Organisme : Natural Sciences and Engineering Research Council of Canada - Discovery Grant
ID : DGECR-2020-00136
Organisme : Canadian Foundation for Innovation - John R. Evans Leaders Fund
ID : 38351
Organisme : Ontario Research Fund
ID : 38351
Informations de copyright
© 2024 The Authors. The Journal of Physiology published by John Wiley & Sons Ltd on behalf of The Physiological Society.
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