MASLD can cause halitosis by small intestinal bacterial overgrowth.
dimethyl sulfide
extra‐oral halitosis
hydrogen breath test
metabolic dysfunction‐associated steatotic liver disease
small intestinal bacterial overgrowth
Journal
Oral diseases
ISSN: 1601-0825
Titre abrégé: Oral Dis
Pays: Denmark
ID NLM: 9508565
Informations de publication
Date de publication:
19 May 2024
19 May 2024
Historique:
revised:
14
04
2024
received:
23
02
2024
accepted:
30
04
2024
medline:
20
5
2024
pubmed:
20
5
2024
entrez:
20
5
2024
Statut:
aheadofprint
Résumé
Patients with metabolic dysfunction-associated steatotic liver disease (MASLD) exhibit varying degrees of halitosis. The author speculated that small intestinal bacterial overgrowth (SIBO) might lead to MASLD and subsequent extra-oral halitosis and aimed to test this hypothesis. This retrospective cross-sectional study reviewed 885 extra-oral halitosis patients. Halitosis and exhaled dimethyl sulfide (DMS) were measured by organoleptic score (OLS) (0-5) and OralChroma, respectively. SIBO and MASLD were diagnosed by hydrogen breath test and Fibroscan combined with cardiometabolic criteria. In this study, 133/885 (15.05%) of the halitosis patients otherwise healthy had MASLD, while 87/133 (65.41%) of the MASLD patients were SIBO-positive. No significant differences were observed in physical parameters such as age, serum biochemical parameters such as lipids, or Fibroscan parameters between the SIBO-positive and SIBO-negative patients. However, the OLS was 4 (interquartile range: 3-4) and exhaled DMS level was 56 (43-75) parts per billion (ppb) in the SIBO-positive patients, significantly greater than 2 (2-3) and 43 (25-51) ppb in the SIBO-negative patients (both p < 0.001). Exhaled hydrogen levels positively correlated with the OLS and exhaled DMS levels (r = 0.774, r = 0.740, both p < 0.001). MASLD can cause halitosis by SIBO.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Natural Science Foundation of China
ID : 81900494
Informations de copyright
© 2024 Wiley Periodicals LLC.
Références
Bilson, J., Mantovani, A., Byrne, C. D., & Targher, G. (2024). Steatotic liver disease, MASLD and risk of chronic kidney disease. Diabetes & Metabolism, 50(1), 101506. https://doi.org/10.1016/j.diabet.2023.101506
Briceag, R., Caraiane, A., Raftu, G., Horhat, R. M., Bogdan, I., Fericean, R. M., Shaaban, L., Popa, M., Bumbu, B. A., Bratu, M. L., Pricop, M., & Talpos, S. (2023). Emotional and social impact of halitosis on adolescents and young adults: A systematic review. Medicina (Kaunas, Lithuania), 59(3), 564. https://doi.org/10.3390/medicina59030564
Chen, Y., & Qian, X. X. (2024). Gastric Helicobacter pylori infection does not contribute to extraoral halitosis and its eradication cannot achieve substantial reduction of halitosis. Helicobacter, 29, e13047. https://doi.org/10.1111/hel.13047
Efremova, I., Maslennikov, R., Poluektova, E., Vasilieva, E., Zharikov, Y., Suslov, A., Letyagina, Y., Kozlov, E., Levshina, A., & Ivashkin, V. (2023). Epidemiology of small intestinal bacterial overgrowth. World Journal of Gastroenterology, 29(22), 3400–3421. https://doi.org/10.3748/wjg.v29.i22.3400
Gkolfakis, P., Tziatzios, G., Leite, G., Papanikolaou, I. S., Xirouchakis, E., Panayiotides, I. G., Karageorgos, A., Millan, M. J., Mathur, R., Weitsman, S., Dimitriadis, G. D., Giamarellos‐Bourboulis, E. J., Pimentel, M., & Triantafyllou, K. (2023). Prevalence of small intestinal bacterial overgrowth syndrome in patients with non‐alcoholic fatty liver disease/non‐alcoholic steatohepatitis: A cross‐sectional study. Microorganisms, 11(3), 723. https://doi.org/10.3390/microorganisms11030723
Gudan, A., Jamioł‐Milc, D., Hawryłkowicz, V., Skonieczna‐Żydecka, K., & Stachowska, E. (2022). The prevalence of small intestinal bacterial overgrowth in patients with non‐alcoholic liver diseases: NAFLD, NASH, fibrosis, cirrhosis‐a systematic review, meta‐analysis and meta‐regression. Nutrients, 14(24), 5261. https://doi.org/10.3390/nu14245261
Gudan, A., Kozłowska‐Petriczko, K., Wunsch, E., Bodnarczuk, T., & Stachowska, E. (2023). Small intestinal bacterial overgrowth and non‐alcoholic fatty liver disease: What do we know in 2023? Nutrients, 15(6), 1323. https://doi.org/10.3390/nu15061323
Hammer, H. F., Fox, M. R., Keller, J., Salvatore, S., Basilisco, G., Hammer, J., Lopetuso, L., Benninga, M., Borrelli, O., Dumitrascu, D., Hauser, B., Herszenyi, L., Nakov, R., Pohl, D., Thapar, N., Sonyi, M., & European H2‐CH4‐Breath Test Group. (2022). European guideline on indications, performance, and clinical impact of hydrogen and methane breath tests in adult and pediatric patients: European Association for Gastroenterology, endoscopy and nutrition, European Society of Neurogastroenterology and Motility, and European Society for Paediatric Gastroenterology Hepatology and Nutrition consensus. United European Gastroenterology Journal, 10(1), 15–40. https://doi.org/10.1002/ueg2.12133
Han, D. H., Lee, S. M., Lee, J. G., Kim, Y. J., & Kim, J. B. (2014). Association between viral hepatitis B infection and halitosis. Acta Odontologica Scandinavica, 72(4), 274–282. https://doi.org/10.3109/00016357.2013.823645
Harvey‐Woodworth, C. N. (2013). Dimethylsulphidemia: The significance of dimethyl sulphide in extra‐oral, blood borne halitosis. British Dental Journal, 214(7), E20. https://doi.org/10.1038/sj.bdj.2013.329
Huang, R., & Rao, H. Y. (2023). Fatty liver disease's renaming impacts on drug clinical trials. Chinese Journal of Hepatology, 31(8), 793–797. In Chinese. https://doi.org/10.3760/cma.j.cn501113‐20230801‐00026
Li, H., Wang, X. K., Tang, M., Lei, L., Li, J. R., Sun, H., Jiang, J., Dong, B., Li, H.‐Y., Jiang, J.‐D., & Peng, Z. G. (2024). Bacteroides thetaiotaomicron ameliorates mouse hepatic steatosis through regulating gut microbial composition, gut‐liver folate and unsaturated fatty acids metabolism. Gut Microbes, 16(1), 2304159. https://doi.org/10.1080/19490976.2024.2304159
Li, Z., Li, J., Fu, R., Liu, J., Wen, X., & Zhang, L. (2023). Halitosis: Etiology, prevention, and the role of microbiota. Clinical Oral Investigations, 27(11), 6383–6393. https://doi.org/10.1007/s00784‐023‐05292‐9
Mikolasevic, I., Delija, B., Mijic, A., Stevanovic, T., Skenderevic, N., Sosa, I., Krznaric‐Zrnic, I., Abram, M., Krznaric, Z., Domislovic, V., Kanizaj, T. F., Radic‐Kristo, D., Cubranic, A., Grubesic, A., Nakov, R., Skrobonja, I., Stimac, D., & Hauser, G. (2021). Small intestinal bacterial overgrowth and non‐alcoholic fatty liver disease diagnosed by transient elastography and liver biopsy. International Journal of Clinical Practice, 75(4), e13947. https://doi.org/10.1111/ijcp.13947
Pimentel, M., Saad, R. J., Long, M. D., & Rao, S. S. C. (2020). ACG clinical guideline: Small intestinal bacterial overgrowth. The American Journal of Gastroenterology, 115(2), 165–178. https://doi.org/10.14309/ajg.0000000000000501
Qian, X. X. (2024a). Characteristics of extra‐oral halitosis induced by functional constipation: A prospective cohort study. Journal of Breath Research, 18(2), 026006. https://doi.org/10.1088/1752‐7163/ad2213
Qian, X. X. (2024b). Enterogenous extra‐oral halitosis has a more severe impact on quality of life in females compared to males. Journal of Breath Research, 18(2), 026005. https://doi.org/10.1088/1752‐7163/ad2003
Rezaie, A., Buresi, M., Lembo, A., Lin, H., McCallum, R., Rao, S., Schmulson, M., Valdovinos, M., Zakko, S., & Pimentel, M. (2017). Hydrogen and methane‐based breath testing in gastrointestinal disorders: The north American consensus. The American Journal of Gastroenterology, 112(5), 775–784. https://doi.org/10.1038/ajg.2017.46
Rinella, M. E., Lazarus, J. V., Ratziu, V., Francque, S. M., Sanyal, A. J., Kanwal, F., Romero, D., Abdelmalek, M. F., Anstee, Q. M., Arab, J. P., Arrese, M., Bataller, R., Beuers, U., Boursier, J., Bugianesi, E., Byrne, C. D., Castro Narro, G. E., Chowdhury, A., Cortez‐Pinto, H., … NAFLD Nomenclature Consensus Group. (2023). A multisociety Delphi consensus statement on new fatty liver disease nomenclature. Hepatology, 78(6), 1966–1986. https://doi.org/10.1097/HEP.0000000000000520
Santaella, N. G., Simpione, G., Maciel, A. P., Lauris, J. R., & da Silva Santos, P. S. (2021). Volatile sulphur compounds in people with chronic kidney disease and the impact on quality of life. Odontology, 109(3), 561–567. https://doi.org/10.1007/s10266‐020‐00576‐y
Scully, C., & Greenman, J. (2012). Halitology (breath odour: Aetiopathogenesis and management). Oral Diseases, 18(4), 333–345. https://doi.org/10.1111/j.1601‐0825.2011.01890.x
Seemann, R., Duarte da Conceicao, M., Filippi, A., Greenman, J., Lenton, P., Nachnani, S., Quirynen, M., Roldan, S., Schulze, H., Sterer, N., Tangerman, A., Winkel, E. G., Yaegaki, K., & Rosenberg, M. (2014). Halitosis management by the general dental practitioner‐results of an international consensus workshop. Swiss Dental Journal, 124(11), 1205–1211. In German.
Shahbaz, M., Kazmi, F., Majeed, H. A., Manzar, S., Qureshi, F. A., & Rashid, S. (2023). Oral manifestations: A reliable indicator for undiagnosed diabetes mellitus patients. European Journal of Dentistry, 17(3), 784–789. https://doi.org/10.1055/s‐0042‐1755553
Shi, H., Mao, L., Wang, L., Quan, X., Xu, X., Cheng, Y., Zhu, S., & Dai, F. (2021). Small intestinal bacterial overgrowth and orocecal transit time in patients of nonalcoholic fatty liver disease. European Journal of Gastroenterology & Hepatology, 33(1S Suppl 1), e535–e539. https://doi.org/10.1097/MEG.0000000000002157
Song, R., Li, Z., Zhang, Y., Tan, J., & Chen, Z. (2024). Comparison of NAFLD, MAFLD and MASLD characteristics and mortality outcomes in United States adults. Liver International, 44(4), 1051–1060. https://doi.org/10.1111/liv.15856
Song, S. J., Lai, J. C., Wong, G. L., Wong, V. W., & Yip, T. C. (2024). Can we use old NAFLD data under the new MASLD definition? Journal of Hepatology, 80(2), e54–e56. https://doi.org/10.1016/j.jhep.2023.07.021
Tangerman, A., Meuwese‐Arends, M. T., & Jansen, J. B. (1994). Cause and composition of foetor hepaticus. Lancet, 343(8895), 483. https://doi.org/10.1016/s0140‐6736(94)92729‐4
Tangerman, A., & Winkel, E. G. (2010). Extra‐oral halitosis: An overview. Journal of Breath Research, 4(1), 017003. https://doi.org/10.1088/1752‐7155/4/1/017003
Van den Velde, S., Nevens, F., Van Hee, P., van Steenberghe, D., & Quirynen, M. (2008). GC‐MS analysis of breath odor compounds in liver patients. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 875(2), 344–348. https://doi.org/10.1016/j.jchromb.2008.08.031
Wei, J., Feng, J., Chen, L., Yang, Z., Tao, H., Li, L., Xuan, J., & Wang, F. (2022). Small intestinal bacterial overgrowth is associated with clinical relapse in patients with quiescent Crohn's disease: A retrospective cohort study. Annals of Translational Medicine, 10(14), 784. https://doi.org/10.21037/atm‐22‐3335