Exploring the impact of solar radiation on skin microbiome to develop improved photoprotection strategies.
exposome
photoprotection
skin microbiome
solar radiation
ultraviolet radiation
Journal
Photochemistry and photobiology
ISSN: 1751-1097
Titre abrégé: Photochem Photobiol
Pays: United States
ID NLM: 0376425
Informations de publication
Date de publication:
20 May 2024
20 May 2024
Historique:
revised:
29
03
2024
received:
25
02
2024
accepted:
25
04
2024
medline:
20
5
2024
pubmed:
20
5
2024
entrez:
20
5
2024
Statut:
aheadofprint
Résumé
The skin microbiome undergoes constant exposure to solar radiation (SR), with its effects on health well-documented. However, understanding SR's influence on host-associated skin commensals remains nascent. This review surveys existing knowledge on SR's impact on the skin microbiome and proposes innovative sun protection methods that safeguard both skin integrity and microbiome balance. A team of skin photodamage specialists conducted a comprehensive review of 122 articles sourced from PubMed and Research Gateway. Key terms included skin microbiome, photoprotection, photodamage, skin cancer, ultraviolet radiation, solar radiation, skin commensals, skin protection, and pre/probiotics. Experts offered insights into novel sun protection products designed not only to shield the skin but also to mitigate SR's effects on the skin microbiome. Existing literature on SR's influence on the skin microbiome is limited. SR exposure can alter microbiome composition, potentially leading to dysbiosis, compromised skin barrier function, and immune system activation. Current sun protection methods generally overlook microbiome considerations. Tailored sun protection products that prioritize both skin and microbiome health may offer enhanced defense against SR-induced skin conditions. By safeguarding both skin and microbiota, these specialized products could mitigate dysbiosis risks associated with SR exposure, bolstering skin defense mechanisms and reducing the likelihood of SR-mediated skin issues.
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : ISDIN SL
Informations de copyright
© 2024 ISDIN S.A. Photochemistry and Photobiology published by Wiley Periodicals LLC on behalf of American Society for Photobiology.
Références
Belkaid Y, Segre JA. Dialogue between skin microbiota and immunity. Science (New York, NY). 2014;346(6212):954‐959.
Lee H‐J, Kim M. Skin barrier function and the microbiome. Int J Mol Sci. 2022;23(21):13071.
Gill SR, Pop M, Deboy RT, et al. Metagenomic analysis of the human distal gut microbiome. Science. 2006;312:1355‐1359.
Grice EA, Segre JA. The skin microbiome. Nat Rev Microbiol. 2011;9:244‐253.
Ratanapokasatit Y, Laisuan W, Rattananukrom T, Petchlorlian A, Thaipisuttikul I, Sompornrattanaphan M. How microbiomes affect skin aging: the updated evidence and current perspectives. Life (Basel, Switzerland). 2022;12:936.
Baldwin HE, Bhatia ND, Friedman A, Eng RM, Seite S. The role of cutaneous microbiota harmony in maintaining a functional skin barrier. J Drugs Dermatol. 2017;16(1):12‐18.
Balato A, Cacciapuoti S, Di Caprio R, et al. Human microbiome: composition and role in inflammatory skin diseases. Arch Immunol Ther Exp. 2019;6:1‐18.
Belizário JE, Napolitano M. Human microbiomes and their roles in dysbiosis, common diseases, and novel therapeutic approaches. Front Microbiol. 2015;6:1050.
Bhatt AP, Redinbo MR, Bultman SJ. The role of the microbiome in cancer development and therapy. CA Cancer J Clin. 2017;67:326‐344.
Dominguez‐Bello MG, Godoy‐Vitorino F, Knight R, Blaser MJ. Role of the microbiome in human development. Gut. 2019;68:1108‐1114.
Chambers ES, Vukmanovic‐Stejic M. Skin barrier immunity and ageing. Skin Barrier Immunity and Ageing Immunology. 2020;160:116‐125.
Vrijheid M. The exposome: a new paradigm to study the impact of environment on health. Thorax. 2014;69:876‐878.
Agache I, Miller R, Gern JE, et al. Emerging concepts and challenges in implementing the exposome paradigm in allergic diseases and asthma: a Practall document. Allergy. 2019;74:449‐463.
Vineis P, Robinson O, Chadeau‐Hyam M, Dehghan A, Mudway I, Dagnino S. What is new in the exposome? Environ Int. 2020;143:105887.
Buck Louis GM, Sundaram R. Exposome: time for transformative research. Stat Med. 2012;31:2569‐2575.
Miller GW, Jones DP. The nature of nurture: refining the definition of the exposome. Tocicol Sci. 2014;137:1‐2.
Wild CP. The exposome: from concept to utility. Int J Epidemiol. 2012;41:24‐32.
Kim BE, Leung DYM. Significance of skin barrier dysfunction in atopic dermatitis. Allergy, Asthma Immunol Res. 2018;10:207‐215.
Kobayashi T, Glatz M, Horiuchi K, et al. Dysbiosis and Staphylococcus aureus colonization drives inflammation in atopic dermatitis. Immunity. 2015;42:756‐766.
McDonald D, Ackermann G, Khailova L, et al. Extreme dysbiosis of the microbiome in critical illness. mSphere. 2016;1:e00199‐e00206.
Lai A, Owens K, Patel S, Nicholas M. The impact of air pollution on atopic dermatitis. Curr Allergy Asthma Rep. 2023;23:435‐442.
Dréno B, Dagnelie MA, Khammari A, Corvec S. The skin microbiome: a new actor in inflammatory acne. Am J Clin Dermatol. 2020;21(Suppl 1):1‐24.
Celebi Sozener Z, Özbey Yücel Ü, Altiner S, et al. The external exposome and allergies: from the perspective of the epithelial barrier hypothesis. Front Allergy. 2022;3:887672.
Marson J, Bhatia N, Graber E, et al. Supplement Article: The role of epidermal barrier dysfunction and cutaneous microbiome dysbiosis in the pathogenesis and manageme.
Edslev SM, Agner T, Andersen PS. Skin microbiome in atopic dermatitis. Acta Derm Venereol. 2020;100:adv.
Woo YR, Cho SH, Lee JD, Kim HS. The human microbiota and skin cancer. Int J Mol Sci. 2022;23(3):1813.
Mekadim C, Skalnikova HK, Cizkova J, et al. Dysbiosis of skin microbiome and gut microbiome in melanoma progression. BMC Microbiol. 2022;22:63.
Bensadoun RJ, Humbert P, Krutman J, et al. Daily baseline skin care in the prevention, treatment, and supportive care of skin toxicity in oncology patients: recommendations from a multinational expert panel. Cancer Manag Res. 2013;5:401‐408.
Krutmann J. Ultraviolet a radiation‐induced biological effects in human skin: relevance for photoaging and photodermatosis. J Dermatol Sci. 2000;23(Suppl 1):S22‐S26.
Krutmann J, Bouloc A, Sore G, Bernard BA, Passeron T. The skin aging exposome. J Dermatol Sci. 2017;85:152‐161.
Krutmann J, Granger C, Trullàs C, Passeron T. Daily photoprotection: what does it really mean? Photodermatol Photoimmunol Photomed. 2021;37:569‐570.
Krutmann J, Morita A, Chung JH. Sun exposure: what molecular photodermatology tells us about its good and bad sides. J Invest Dermatol. 2012;132:976‐984.
Krutmann J, Passeron T, Gilaberte Y, et al. Photoprotection of the future: challenges and opportunities. J Eur Acad Dermatol Venereol. 2020;34:447‐454.
Liebert A, Bicknell B, Johnstone DM, Gordon LC, Kiat H, Hamblin MR. "Photobiomics": can light, including Photobiomodulation, Alter the microbiome? Photobiomodul Photomed Laser Surg. 2019;37:681‐693.
Rai S, Rai G, Kumar A. Eco‐evolutionary impact of ultraviolet radiation (UVR) exposure on microorganisms, with a special focus on our skin microbiome. Microbiol Res. 2022;260:127044.
Lautenschlager S, Wulf HC, Pittelkow MR. Photoprotection. Photoprotection Lancet. 2007;370:528‐537.
Garnacho Saucedo GM, Salido Vallejo R, Moreno Giménez JC. Effects of solar radiation and an update on photoprotection. An Pediatr (Engl Ed). 2020;92:377.e1‐e9.
Li H, Colantonio S, Dawson A, Lin X, Beecker J. Sunscreen application, safety, and Sun protection: the evidence. J Cutan Med Surg. 2019;23:357‐369.
Kurz B, Berneburg M, Singer S. Sonnenschutz der menschlichen Haut: Grundlagen. Hautarzt. 2022;73:251‐256.
Guan LL, Lim HW, Mohammad TF. Sunscreens and photoaging: a review of current literature. Am J Clin Dermatol. 2021;22:819‐828.
Searle T, Al‐Niaimi F, Ali FR. Visible light and hyperpigmentation: the invisible culprit. Clin Exp Dermatol. 2021;46:995‐997.
Patra V, Byrne SN, Wolf P. The skin microbiome: is it affected by UV‐induced immune suppression? Front Microbiol. 2016;7:1235.
Patra V, Wagner K, Arulampalam V, Wolf P. Skin microbiome modulates the effect of ultraviolet radiation on cellular response and immune function. iScience. 2019;15:2112‐2122.
Burns EM, Ahmed H, Isedeh PN, et al. Ultraviolet radiation, both UVA and UVB, influences the composition of the skin microbiome. Exp Dermatol. 2019;28:136‐141.
Fernández RO, Pizarro RA. Lethal effect induced in Pseudomonas aeruginosa exposed to ultraviolet‐a radiation. Photochem Photobiol. 1996;64:334‐339.
Schuetz R, Claypool J, Sfriso R, Vollhardt JH. Sunscreens can preserve human skin microbiome upon erythemal UV exposure. Int J Cosmet Sci. 2024;46(1):71‐84.
Willmott T, Campbell PM, Griffiths CEM, et al. Behaviour and sun exposure in holidaymakers alters skin microbiota composition and diversity. Front Aging. 2023;4:1217635.
Harel N, Reshef L, Biran D, Brenner S, Ron EZ, Gophna U. Effect of solar radiation on skin microbiome: study of Two populations. Microorganisms. 2022;10:1523.
Smith M, O'Neill C, Dickinson M, Chavan B, McBain A. Exploring associations between skin, the dermal microbiome, and ultraviolet radiation: advancing possibilities for next‐generation sunscreens. Front Microbiomes. 2023;2:1‐11.
Kong HH, Segre JA. Skin microbiome: looking back to move forward. J Invest Dermatol. 2012;132:933‐939.
Nakatsuji T, Chen TH, Butcher AM, et al. A commensal strain of Staphylococcus epidermidis protects against skin neoplasia. Sci Adv. 2018;4:eaao4502.
Balasubramaniam A, Adi P, Do Thi TM, Yang JH, Labibah AS, Huang CM. Skin bacteria mediate glycerol fermentation to produce electricity and resist UV‐B. Microorganisms. 2020;8:1092.
Shiota S, Nakayama H. UV endonuclease of Micrococcus luteus, a cyclobutane pyrimidine dimer‐DNA glycosylase/abasic lyase: cloning and characterization of the gene. Proc Natl Acad Sci USA. 1997;94:593‐598.
Mohana DC, Thippeswamy S, Abhishek RU. Antioxidant, antibacterial, and ultraviolet‐protective properties of carotenoids isolated from Micrococcus spp. Rad Protect Env. 2013;36:168.
Biragyn A, Ruffini PA, Leifer CA, et al. Toll‐like receptor 4‐dependent activation of dendritic cells by beta‐defensin 2. Science. 2002;298:1025‐1029.
Chadebech P, Goidin D, Jacquet C, Viac J, Schmitt D, Staquet MJ. Use of human reconstructed epidermis to analyze the regulation of beta‐defensin hBD‐1, hBD‐2, and hBD‐3 expression in response to LPS. Cell Biol Toxicol. 2003;19:313‐324.
Niyonsaba F, Ushio H, Nakano N, et al. Antimicrobial peptides human beta‐defensins stimulate epidermal keratinocyte migration, proliferation and production of proinflammatory cytokines and chemokines. J Invest Dermatol. 2007;127:594‐604.
Kolls JK, McCray PB Jr, Chan YR. Cytokine‐mediated regulation of antimicrobial proteins. Nat Rev Immunol. 2008;8:829‐835.
Chapman RS, Cooper KD, De Fabo EC, et al. Solar ultraviolet radiation and the risk of infectious disease: summary of a workshop. Photochem Photobiol. 1995;61:223‐247.
Meisel JS, Sfyroera G, Bartow‐McKenney C, et al. Commensal microbiota modulate gene expression in the skin. Microbiome. 2018;6:20.
Williams MR, Costa SK, Zaramela LS, et al. Quorum sensing between bacterial species on the skin protects against epidermal injury in atopic dermatitis. Sci Transl Med. 2019;11:eaat8329.
Boxberger M, Cenizo V, Cassir N, La Scola B. Challenges in exploring and manipulating the human skin microbiome. Microbiome. 2021;9:125.
Nakatsuji T, Chen TH, Narala S, et al. Antimicrobials from human skin commensal bacteria protect against Staphylococcus aureus and are deficient in atopic dermatitis. Sci Transl Med. 2017;9:eaah4680.
Canesso MC, Vieira AT, Castro TB, et al. Skin wound healing is accelerated and scarless in the absence of commensal microbiota. J Immunol. 2014;193:5171‐5180.
Lai Y, Di Nardo A, Nakatsuji T, et al. Commensal bacteria regulate toll‐like receptor 3‐dependent inflammation after skin injury. Nat Med. 2009;15:1377‐1382.
Harrison OJ, Linehan JL, Shih HY, et al. Commensal‐specific T cell plasticity promotes rapid tissue adaptation to injury. Science. 2019;363:eaat6280.
Gläser R, Navid F, Schuller W, et al. UV‐B radiation induces the expression of antimicrobial peptides in human keratinocytes in vitro and in vivo. J Allergy Clin Immunol. 2009;123:1117‐1123.
Gallo RL, Hooper LV. Epithelial antimicrobial defence of the skin and intestine. Nat Rev Immunol. 2012;12:503‐516.
Faergemann J, Larko O. The effect of UV‐light on human skin microorganisms. Acta Derm Venereol. 1987;67:69‐72.
Kullander J, Forslund O, Dillner J. Staphylococcus aureus and squamous cell carcinoma of the skin. Cancer Epidemiol Biomarkers Prevent. 2009;18:472‐478.
Wood DLA, Lachner N, Tan JM, et al. A natural history of actinic keratosis and cutaneous squamous cell carcinoma microbiomes. MBio. 2018;9:e01432‐18.
Madhusudhan N, Pausan MR, Halwachs B, et al. Molecular profiling of keratinocyte skin tumors links Staphylococcus aureus overabundance and increased human β‐Defensin‐2 expression to growth promotion of squamous cell carcinoma. Cancer (Basel). 2020;12:541.
Young AR, Claveau J, Rossi AB. Ultraviolet radiation and the skin: photobiology and sunscreen photoprotection. J Am Acad Dermatol. 2017;76:S100‐S109.
Souak D, Barreau M, Courtois A, et al. Challenging cosmetic innovation: the Skin microbiota and probiotics protect the skin from UV‐induced damage. Microorganisms. 2021;9:936.
Teng Y, Huang Y, Danfeng X, Tao X, Fan Y. The role of probiotics in skin photoaging and related mechanisms: a review. Clin Cosmet Investig Dermatol. 2022;15:2455‐2464.
Habeebuddin M, Karnati RK, Shiroorkar PN, et al. Topical probiotics: more than a skin deep. Pharmaceutics. 2022;14:557.
Valdéz JC, Peral MC, Rachid M, Santana M, Perdigón G. Interference of lactobacillus plantarum with Pseudomonas aeruginosa in vitro and in infected burns: the potential use of probiotics in wound treatment. Clin Microbiol Infect. 2005;11:472‐479.
Gueniche A, Philippe D, Bastien P, Blum S, Buyukpamukcu E, Castiel‐Higounenc I. Probiotics for photoprotection. Dermato Endocrinol. 2009;1:275‐279.
Baquerizo Nole KL, Yim E, Keri JE. Probiotics and prebiotics in dermatology. J Am Acad Dermatol. 2014;71:814‐821.
Shaheen AE, Gebreel HM, Moussa LA, Zakaria AE, Nemr WA. Photoprotection against UV‐induced skin damage using hyaluronic acid produced by Lactiplantibacillus plantarum and Enterococcus durans. Curr Microbiol. 2023;80:262.
Tanaka H, Yamaba H, Kosugi N, Mizutani H, Nakata S. Fermentable metabolite of Zymomonas mobilis controls collagen reduction in photoaging skin by improving TGF‐beta/Smad signaling suppression. Arch Dermatol Res. 2008;300:S57‐S64.
Chen H, Li Y, Xie X, et al. Exploration of the molecular mechanisms underlying the anti‐photoaging effect of Limosilactobacillus fermentum XJC60. Front Cell Infect Microbiol. 2022;12:838060.
Keshari S, Balasubramaniam A, Myagmardoloonjin B, Herr DR, Negari IP, Huang CM. Butyric acid from probiotic Staphylococcus epidermidis in the skin microbiome Down‐regulates the ultraviolet‐induced pro‐inflammatory IL‐6 cytokine via short‐chain fatty acid receptor. Int J Mol Sci. 2019;20:4477.
Balasubramaniam A, Adi P, Tra My DT, et al. Repurposing INCI‐registered compounds as skin prebiotics for probiotic Staphylococcus epidermidis against UV‐B. Sci Rep. 2020;10:21585.
Lu Y, Liu M, Cao Y, et al. Hydrogel sunscreen based on yeast /gelatin demonstrates excellent UV‐shielding and skin protection performance. Colloids Surf B Biointerfaces. 2021;205:111885.
Khmaladze I, Butler É, Fabre S, Gillbro JM. Lactobacillus reuteri DSM 17938‐a comparative study on the effect of probiotics and lysates on human skin. Exp Dermatol. 2019;28:822‐828.
Mahé YF, Martin R, Aubert L, et al. Induction of the skin endogenous protective mitochondrial MnSOD by Vitreoscilla filiformis extract. Int J Cosmet Sci. 2006;28:277‐287.
Sugimoto S, Ishii Y, Izawa N, et al. Photoprotective effects of Bifidobacterium breve supplementation against skin damage induced by ultraviolet irradiation in hairless mice. Photodermatol Photoimmunol Photomed. 2012;28:312‐319.
Ishii Y, Sugimoto S, Izawa N, Sone T, Chiba K, Miyazaki K. Oral administration of Bifidobacterium breve attenuates UV‐induced barrier perturbation and oxidative stress in hairless mice skin. Arch Dermatol Res. 2014;306:467‐473.
Satoh T, Murata M, Iwabuchi N, et al. Effect of Bifidobacterium breve B‐3 on skin photoaging induced by chronic UV irradiation in mice. Benefic Microbes. 2015;6:497‐504.
Lee JY, Park JY, Kim Y, Kang CH. Protective effect of Bifidobacterium animalis subs. Lactis MG741 as probiotics against UVB‐exposed fibroblasts and hairless mice. Microorganisms. 2022;10:2343.
Hong KB, Jeong M, Han KS, Hwan Kim J, Park Y, Suh HJ. Photoprotective effects of galacto‐oligosaccharide and/or Bifidobacterium longum supplementation against skin damage induced by ultraviolet irradiation in hairless mice. Int J Food Sci Nutr. 2015;68:923‐930.
Kim D, Lee KR, Kim NR, Park SJ, Lee M, Kim OK. Combination of Bifidobacterium longum and Galacto‐oligosaccharide protects the skin from photoaging. J Med Food. 2021;24:606‐616.
Im AR, Kim HS, Hyun JW, Chae S. Potential for tyndalized lactobacillus acidophilus as an effective component in moisturizing skin and anti‐wrinkle products. Exp Ther Med. 2016;12:759‐764.
Im AR, Lee B, Kang DJ, Chae S. Skin moisturizing and antiphotodamage effects of Tyndallized lactobacillus acidophilus IDCC 3302. J Med Food. 2018;21:1016‐1023.
Gueniche A, Benyacoub J, Buetler TM, Smola H, Blum S. Supplementation with oral probiotic bacteria maintains cutaneous immune homeostasis after UV exposure. Eur J Dermatol. 2006;16:511‐517.
Weill FS, Cela EM, Paz ML, Ferrari A, Leoni J, González Maglio DH. Lipoteichoic acid from Lactobacillus rhamnosus GG as an oral photoprotective agent against UV‐induced carcinogenesis. Br J Nutr. 2013;109:457‐466.
Friedrich AD, Campo VE, Cela EM, et al. Oral administration of lipoteichoic acid from Lactobacillus rhamnosus GG overcomes UVB‐induced immunosuppression and impairs skin tumor growth in mice. Eur J Immunol. 2019;49:2095‐2102.
Ra J, Lee DE, Kim SH, et al. Effect of oral administration of Lactobacillus plantarum HY7714 on epidermal hydration in ultraviolet B‐irradiated hairless mice. J Microbiol Biotechnol. 2014;24:1736‐1743.
Peguet‐Navarro J, Dezutter‐Dambuyant C, Buetler T, et al. Supplementation with oral probiotic bacteria protects human cutaneous immune homeostasis after UV exposure‐double blind, randomized, placebo controlled clinical trial. Eur J Dermatol. 2008;18:504‐511.
Marini A, Jaenicke T, Grether‐Beck S, et al. Prevention of polymorphic light eruption by oral administration of a nutritional supplement containing lycopene, β‐carotene, and Lactobacillus johnsonii: results from a randomized, placebo‐controlled, double‐blinded study. Photodermatol Photoimmunol Photomed. 2014;30:189‐194.
Bouilly‐Gauthier D, Jeannes C, Maubert Y, et al. Clinical evidence of benefits of a dietary supplement containing probiotic and carotenoids on ultraviolet‐induced skin damage. Br J Dermatol. 2010;163:536‐543.
Seo E, Song HH, Kim H, et al. Oral Administration of Mixed Probiotics Improves Photoaging by modulating the Cecal microbiome and MAPK pathway in UVB‐irradiated hairless mice. Mol Nutr Food Res. 2023;67:e2200841.
Tao K, Noda A, Yonei S. The roles of different excision‐repair mechanisms in the resistance of Micrococcus luteus to UV and chemical mutagens. Mutat Res. 1987;183:231‐239.
Lossius AH, Sundnes O, Ingham AC, et al. Shifts in the skin microbiota after UVB treatment in adult atopic dermatitis. Dermatology. 2022;238:109‐120.
Appenzeller BMR, Chadeau‐Hyam M, Aguilar L. Skin exposome science in practice: current evidence on hair biomonitoring and future perspectives. J Eur Acad Dermatol Venereol. 2020;34(Suppl 4):26‐30.
Cecchi L, D'Amato G, Annesi‐Maesano I. External exposome and allergic respiratory and skin diseases. J Allergy Clin Immunol. 2018;141:846‐857.
Celebi Sözener Z, Cevhertas L, Nadeau K, Akdis M, Akdis CA. Environmental factors in epithelial barrier dysfunction. J Allergy Clin Immunol. 2020;145:1517‐1528.
Dreno B, Bettoli V, Araviiskaia E, Sanchez Viera M, Bouloc A. The influence of exposome on acne. J Eur Acad Dermatol Venereol. 2018;32:812‐819.
Dreno B, Shourick J, Kerob D, Bouloc A, Taïeb C. The role of exposome in acne: results from an international patient survey. J Eur Acad Dermatol Venereol. 2020;34:1057‐1064.
Molina‐García M, Malvehy J, Granger C, Garre A, Trullàs C, Puig S. Exposome and skin. Part 2. The influential role of the exposome, beyond UVR, in actinic keratosis, Bowen's disease and squamous cell carcinoma: a proposal. Dermatol Ther (Heidelb). 2022;12:361‐380.
Morgado‐Carrasco D, Granger C, Trullas C, Piquero‐Casals J. Impact of ultraviolet radiation and exposome on rosacea: key role of photoprotection in optimizing treatment. J Cosmet Dermatol. 2021;20:3415‐3421.
Passeron T, Krutmann J, Andersen ML, Katta R, Zouboulis CC. Clinical and biological impact of the exposome on the skin. J Eur Acad Dermatol Venereol. 2020;34(Suppl 4):4‐25.
Passeron T, Zouboulis CC, Tan J, et al. Adult skin acute stress responses to short‐term environmental and internal aggression from exposome factors. J Eur Acad Dermatol Venereol. 2021;35:1963‐1975.
Piquero‐Casals J, Morgado‐Carrasco D, Rozas‐Muñoz E, et al. Sun exposure, a relevant exposome factor in acne patients and how photoprotection can improve outcomes. J Cosmet Dermatol. 2023;22:1919‐1928.
Stefanovic N, Flohr C, Irvine AD. The exposome in atopic dermatitis. Allergy. 2020;75(1):63‐74.
Assarsson M, Duvetorp A, Dienus O, Söderman J, Seifert O. Significant changes in the skin microbiome in patients with chronic plaque psoriasis after treatment with narrowband ultraviolet B. Acta Derm Venereol. 2018;98(4):428‐436.
Reid C, Griffiths CEM. Psoriasis and treatment: past, present and future aspects. Acta Derm Venereol. 2020;100(3):70‐80.
Patra V, Bordag N, Clement Y, et al. Ultraviolet exposure regulates skin metabolome based on the microbiome. Sci Rep. 2023;13:7207.
Amin RM, Bhayana B, Hamblin MR, Dai T. Antimicrobial blue light inactivation of Pseudomonas aeruginosa by photo‐excitation of endogenous porphyrins: in vitro and in vivo studies. Lasers Surg Med. 2016;48:562‐568.
Wang Y, Zhu W, Shu M, et al. The response of human skin commensal bacteria as a reflection of UV radiation: UV‐B decreases porphyrin production. PLoS One. 2012;7:e47798.
Torres AE, Luk KM, Lim HW. Botanicals for photoprotection. Plast Aesthet Res. 2020;7:57.
Patra V, Gallais Sérézal I, Wolf P. Potential of skin microbiome, pro‐ and/or pre‐biotics to affect local cutaneous responses to UV exposure. Nutrients. 2020;12:1795.