Carbon substrates promotes stress resistance and drug tolerance in clinical isolates of Candida tropicalis.
Candida tropicalis
/ drug effects
Drug Resistance, Fungal
Antifungal Agents
/ pharmacology
Humans
Fluconazole
/ pharmacology
Oxidative Stress
Carbon
/ metabolism
Microbial Sensitivity Tests
Candidiasis
/ microbiology
Osmotic Pressure
Glucose
/ metabolism
Sucrose
/ metabolism
Hydrogen Peroxide
/ pharmacology
Fructose
/ metabolism
Stress, Physiological
Candida tropicalis
Fluconazole
Fructose
Glucose
Osmotic stress
Oxidative stress
Sucrose
Journal
Archives of microbiology
ISSN: 1432-072X
Titre abrégé: Arch Microbiol
Pays: Germany
ID NLM: 0410427
Informations de publication
Date de publication:
20 May 2024
20 May 2024
Historique:
received:
15
01
2024
accepted:
10
05
2024
revised:
29
04
2024
medline:
20
5
2024
pubmed:
20
5
2024
entrez:
20
5
2024
Statut:
epublish
Résumé
Candida tropicalis is a human pathogen and one of the most prevalent non-Candida albicans Candida (NCAC) species causing invasive infections. Azole antifungal resistance in C. tropicalis is also gradually increasing with the increasing incidence of infections. The pathogenic success of C. tropicalis depends on its effective response in the host microenvironment. To become a successful pathogen, cellular metabolism, and physiological status determine the ability of the pathogen to counter diverse stresses inside the host. However, to date, limited knowledge is available on the impact of carbon substrate metabolism on stress adaptation and azole resistance in C. tropicalis. In this study, we determined the impact of glucose, fructose, and sucrose as the sole carbon source on the fluconazole resistance and osmotic (NaCl), oxidative (H
Identifiants
pubmed: 38767668
doi: 10.1007/s00203-024-04000-9
pii: 10.1007/s00203-024-04000-9
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
270Informations de copyright
© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
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