Sex-specific developmental gene expression atlas unveils dimorphic gene networks in C. elegans.
Animals
Caenorhabditis elegans
/ genetics
Male
Female
Caenorhabditis elegans Proteins
/ genetics
Sex Characteristics
Gene Regulatory Networks
Gene Expression Regulation, Developmental
Neuropeptides
/ genetics
Sensory Receptor Cells
/ metabolism
Transcription Factors
/ metabolism
Gene Expression Profiling
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
20 May 2024
20 May 2024
Historique:
received:
23
07
2023
accepted:
24
04
2024
medline:
21
5
2024
pubmed:
21
5
2024
entrez:
20
5
2024
Statut:
epublish
Résumé
Sex-specific traits and behaviors emerge during development by the acquisition of unique properties in the nervous system of each sex. However, the genetic events responsible for introducing these sex-specific features remain poorly understood. In this study, we create a comprehensive gene expression atlas of pure populations of hermaphrodites and males of the nematode Caenorhabditis elegans across development. We discover numerous differentially expressed genes, including neuronal gene families like transcription factors, neuropeptides, and G protein-coupled receptors. We identify INS-39, an insulin-like peptide, as a prominent male-biased gene expressed specifically in ciliated sensory neurons. We show that INS-39 serves as an early-stage male marker, facilitating the effective isolation of males in high-throughput experiments. Through complex and sex-specific regulation, ins-39 plays pleiotropic sexually dimorphic roles in various behaviors, while also playing a shared, dimorphic role in early life stress. This study offers a comparative sexual and developmental gene expression database for C. elegans. Furthermore, it highlights conserved genes that may underlie the sexually dimorphic manifestation of different human diseases.
Identifiants
pubmed: 38769103
doi: 10.1038/s41467-024-48369-z
pii: 10.1038/s41467-024-48369-z
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
4273Subventions
Organisme : EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 Excellent Science - European Research Council)
ID : ERC-2019-STG 850784
Organisme : Israel Science Foundation (ISF)
ID : 961/21
Informations de copyright
© 2024. The Author(s).
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