Chondroitin sulfate-modified tragacanth gum-gelatin composite nanocapsules loaded with curcumin nanocrystals for the treatment of arthritis.
Curcumin
/ pharmacology
Chondroitin Sulfates
/ chemistry
Gelatin
/ chemistry
Animals
Nanocapsules
/ chemistry
Nanoparticles
/ chemistry
Mice
Tragacanth
/ chemistry
RAW 264.7 Cells
Oxidative Stress
/ drug effects
Arthritis, Rheumatoid
/ drug therapy
Male
Particle Size
Anti-Inflammatory Agents
/ pharmacology
Macrophages
/ metabolism
Drug Liberation
Rats
Curcumin
Gelatin
Gouty arthritis
Rheumatoid arthritis
Tragacanth gum
Journal
Journal of nanobiotechnology
ISSN: 1477-3155
Titre abrégé: J Nanobiotechnology
Pays: England
ID NLM: 101152208
Informations de publication
Date de publication:
20 May 2024
20 May 2024
Historique:
received:
19
02
2024
accepted:
09
05
2024
medline:
21
5
2024
pubmed:
21
5
2024
entrez:
20
5
2024
Statut:
epublish
Résumé
Rheumatoid arthritis (RA) is a chronic autoimmune disease of yet undetermined etiology that is accompanied by significant oxidative stress, inflammatory responses, and damage to joint tissues. In this study, we designed chondroitin sulfate (CS)-modified tragacanth gum-gelatin composite nanocapsules (CS-Cur-TGNCs) loaded with curcumin nanocrystals (Cur-NCs), which rely on the ability of CS to target CD44 to accumulate drugs in inflamed joints. Cur was encapsulated in the form of nanocrystals into tragacanth gum-gelatin composite nanocapsules (TGNCs) by using an inborn microcrystallization method, which produced CS-Cur-TGNCs with a particle size of approximately 80 ± 11.54 nm and a drug loading capacity of 54.18 ± 5.17%. In an in vitro drug release assay, CS-Cur-TGNCs showed MMP-2-responsive properties. During the treatment of RA, CS-Cur-TGNCs significantly inhibited oxidative stress, promoted the polarization of M2-type macrophages to M1-type macrophages, and decreased the expression of inflammatory factors (TNF-α, IL-1β, and IL-6). In addition, it also exerted excellent anti-inflammatory effects, and significantly alleviated the swelling of joints during the treatment of gouty arthritis (GA). Therefore, CS-Cur-TGNCs, as a novel drug delivery system, could lead to new ideas for clinical therapeutic regimens for RA and GA.
Identifiants
pubmed: 38769551
doi: 10.1186/s12951-024-02540-2
pii: 10.1186/s12951-024-02540-2
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
270Subventions
Organisme : Natural Science Foundation of Liaoning Province
ID : 2022-MS-390
Organisme : Scientific Research Project of the Educational Department of Liaoning Province
ID : JYTJCZR202007
Organisme : Liaoning Provincial Key Laboratory of Marine Bioactive Substances and Technological Innovation Center of Liaoning Pharmaceutical Action and Quality Evaluation
ID : 2022-8
Organisme : Application Research Project of Jinzhou Medical University
ID : H2021024
Organisme : Scientific and technological projects of Jinzhou city
ID : JZ2022B042
Organisme : Liaoning Province Applied Basic Research Program Joint Project
ID : 2023021109-JH2/1017
Informations de copyright
© 2024. The Author(s).
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