Chondroitin sulfate-modified tragacanth gum-gelatin composite nanocapsules loaded with curcumin nanocrystals for the treatment of arthritis.


Journal

Journal of nanobiotechnology
ISSN: 1477-3155
Titre abrégé: J Nanobiotechnology
Pays: England
ID NLM: 101152208

Informations de publication

Date de publication:
20 May 2024
Historique:
received: 19 02 2024
accepted: 09 05 2024
medline: 21 5 2024
pubmed: 21 5 2024
entrez: 20 5 2024
Statut: epublish

Résumé

Rheumatoid arthritis (RA) is a chronic autoimmune disease of yet undetermined etiology that is accompanied by significant oxidative stress, inflammatory responses,  and damage to joint tissues. In this study, we designed chondroitin sulfate (CS)-modified tragacanth gum-gelatin composite nanocapsules (CS-Cur-TGNCs) loaded with curcumin nanocrystals (Cur-NCs), which rely on the ability of CS to target CD44 to accumulate drugs in inflamed joints. Cur was encapsulated in the form of nanocrystals into tragacanth gum-gelatin composite nanocapsules (TGNCs) by using an inborn microcrystallization method, which produced CS-Cur-TGNCs with a particle size of approximately 80 ± 11.54 nm and a drug loading capacity of 54.18 ± 5.17%. In an in vitro drug release assay, CS-Cur-TGNCs showed MMP-2-responsive properties. During the treatment of RA, CS-Cur-TGNCs significantly inhibited oxidative stress, promoted the polarization of M2-type macrophages to M1-type macrophages, and decreased the expression of inflammatory factors (TNF-α, IL-1β, and IL-6). In addition, it also exerted excellent anti-inflammatory effects, and significantly alleviated the swelling of joints during the treatment of gouty arthritis (GA). Therefore, CS-Cur-TGNCs, as a novel drug delivery system, could lead to new ideas for clinical therapeutic regimens for RA and GA.

Identifiants

pubmed: 38769551
doi: 10.1186/s12951-024-02540-2
pii: 10.1186/s12951-024-02540-2
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

270

Subventions

Organisme : Natural Science Foundation of Liaoning Province
ID : 2022-MS-390
Organisme : Scientific Research Project of the Educational Department of Liaoning Province
ID : JYTJCZR202007
Organisme : Liaoning Provincial Key Laboratory of Marine Bioactive Substances and Technological Innovation Center of Liaoning Pharmaceutical Action and Quality Evaluation
ID : 2022-8
Organisme : Application Research Project of Jinzhou Medical University
ID : H2021024
Organisme : Scientific and technological projects of Jinzhou city
ID : JZ2022B042
Organisme : Liaoning Province Applied Basic Research Program Joint Project
ID : 2023021109-JH2/1017

Informations de copyright

© 2024. The Author(s).

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Auteurs

Junpeng Sun (J)

Pharmacy School, Jinzhou Medical University, Jinzhou, Liaoning, 121001, China.
Liaoning Provincial Collaborative Innovation Center of Medical Testing and Drug Development, Jinzhou Medical University, Jinzhou, Liaoning, 121001, China.

Jiaqun Du (J)

Pharmacy School, Jinzhou Medical University, Jinzhou, Liaoning, 121001, China.
Liaoning Provincial Collaborative Innovation Center of Medical Testing and Drug Development, Jinzhou Medical University, Jinzhou, Liaoning, 121001, China.

Xiaobang Liu (X)

Pharmacy School, Jinzhou Medical University, Jinzhou, Liaoning, 121001, China.
Liaoning Provincial Collaborative Innovation Center of Medical Testing and Drug Development, Jinzhou Medical University, Jinzhou, Liaoning, 121001, China.

Jinyu An (J)

Pharmacy School, Jinzhou Medical University, Jinzhou, Liaoning, 121001, China.
Liaoning Provincial Collaborative Innovation Center of Medical Testing and Drug Development, Jinzhou Medical University, Jinzhou, Liaoning, 121001, China.

Yu Hu (Y)

Liaoning Provincial Collaborative Innovation Center of Medical Testing and Drug Development, Jinzhou Medical University, Jinzhou, Liaoning, 121001, China.
School of Basic Medicine, Jinzhou Medical University, Jinzhou, Liaoning, 121001, China.

Jing Wang (J)

Pharmacy School, Jinzhou Medical University, Jinzhou, Liaoning, 121001, China.
Liaoning Provincial Collaborative Innovation Center of Medical Testing and Drug Development, Jinzhou Medical University, Jinzhou, Liaoning, 121001, China.

Fu Zhu (F)

Pharmacy School, Jinzhou Medical University, Jinzhou, Liaoning, 121001, China.
Liaoning Provincial Collaborative Innovation Center of Medical Testing and Drug Development, Jinzhou Medical University, Jinzhou, Liaoning, 121001, China.

Huicong Feng (H)

Liaoning Provincial Collaborative Innovation Center of Medical Testing and Drug Development, Jinzhou Medical University, Jinzhou, Liaoning, 121001, China.
School of Basic Medicine, Jinzhou Medical University, Jinzhou, Liaoning, 121001, China.

Shuai Cheng (S)

Liaoning Provincial Collaborative Innovation Center of Medical Testing and Drug Development, Jinzhou Medical University, Jinzhou, Liaoning, 121001, China.
School of Basic Medicine, Jinzhou Medical University, Jinzhou, Liaoning, 121001, China.

He Tian (H)

Liaoning Provincial Collaborative Innovation Center of Medical Testing and Drug Development, Jinzhou Medical University, Jinzhou, Liaoning, 121001, China. tianhe@jzmu.edu.cn.
School of Basic Medicine, Jinzhou Medical University, Jinzhou, Liaoning, 121001, China. tianhe@jzmu.edu.cn.

Xifan Mei (X)

Liaoning Provincial Collaborative Innovation Center of Medical Testing and Drug Development, Jinzhou Medical University, Jinzhou, Liaoning, 121001, China. meixifan@jzmu.edu.cn.
The Third Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning, 121001, China. meixifan@jzmu.edu.cn.
Liaoning Provincial Key Laboratory of Medical Tissue Engineering, Jinzhou Medical University, Jinzhou, Liaoning, 121001, China. meixifan@jzmu.edu.cn.

Chao Wu (C)

Pharmacy School, Jinzhou Medical University, Jinzhou, Liaoning, 121001, China. wuchao@jzmu.edu.cn.
Liaoning Provincial Collaborative Innovation Center of Medical Testing and Drug Development, Jinzhou Medical University, Jinzhou, Liaoning, 121001, China. wuchao@jzmu.edu.cn.
Liaoning Provincial Key Laboratory of Medical Tissue Engineering, Jinzhou Medical University, Jinzhou, Liaoning, 121001, China. wuchao@jzmu.edu.cn.

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