Unlocking the therapeutic potential of TRPV3: Insights into thermosensation, channel modulation, and skin homeostasis involving TRPV3.

TRPV3 temperature

Journal

BioEssays : news and reviews in molecular, cellular and developmental biology

ISSN: 1521-1878

Titre abrégé: Bioessays

Pays: United States

ID NLM: 8510851

Informations de publication

Date de publication:
20 May 2024

Historique:

revised: 02 05 2024

received: 29 02 2024

accepted: 06 05 2024

medline: 21 5 2024

pubmed: 21 5 2024

entrez: 21 5 2024

Statut: aheadofprint

Résumé

Recent insights reveal the significant role of TRPV3 in warmth sensation. A novel finding elucidated how thermosensation is affected by TRPV3 membrane abundance that is modulated by the transmembrane protein TMEM79. TRPV3 is a warmth-sensitive ion channel predominantly expressed in epithelial cells, particularly skin keratinocytes. Multiple studies investigated the roles of TRPV3 in cutaneous physiology and pathophysiology. TRPV3 activation by innocuous warm temperatures in keratinocytes highlights its significance in temperature sensation, but whether TRPV3 directly contributes to warmth sensations in vivo remains controversial. This review explores the electrophysiological and structural properties of TRPV3 and how modulators affect its intricate regulatory mechanisms. Moreover, we discuss the multifaceted involvement of TRPV3 in skin physiology and pathology, including barrier formation, hair growth, inflammation, and itching. Finally, we examine the potential of TRPV3 as a therapeutic target for skin diseases and highlight its diverse role in maintaining skin homeostasis.

Identifiants

DOI: 10.1002/bies.202400047 PMID: 38769699

pubmed: 38769699

doi: 10.1002/bies.202400047

doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

Pagination

e2400047

Subventions

Organisme : Japan Society for the Promotion of Science

ID : 21H02667

Organisme : Japan Society for the Promotion of Science

ID : 23H04943

Informations de copyright

Références

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