Ribosomal dormancy at the nexus of ribosome homeostasis and protein synthesis.
dormant ribosomes
eEF2K
mTOR signaling
protein synthesis
ribophagy
ubiquitin‐proteasome system
Journal
BioEssays : news and reviews in molecular, cellular and developmental biology
ISSN: 1521-1878
Titre abrégé: Bioessays
Pays: United States
ID NLM: 8510851
Informations de publication
Date de publication:
20 May 2024
20 May 2024
Historique:
revised:
05
02
2024
received:
28
12
2023
accepted:
02
05
2024
medline:
21
5
2024
pubmed:
21
5
2024
entrez:
21
5
2024
Statut:
aheadofprint
Résumé
Dormancy or hibernation is a non-proliferative state of cells with low metabolic activity and gene expression. Dormant cells sequester ribosomes in a translationally inactive state, called dormant/hibernating ribosomes. These dormant ribosomes are important for the preservation of ribosomes and translation shut-off. While recent studies attempted to elucidate their modes of formation, the regulation and roles of the diverse dormant ribosomal populations are still largely understudied. The mechanistic details of the formation of dormant ribosomes in stress and especially their disassembly during recovery remain elusive. In this review, we discuss the roles of dormant ribosomes and their potential regulatory mechanisms. Furthermore, we highlight the paradigms that need to be answered in the field of ribosomal dormancy.
Identifiants
pubmed: 38769702
doi: 10.1002/bies.202300247
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2300247Subventions
Organisme : DAE DPR
ID : 1/3(4)/2021/TMC/R&D-II/15063
Organisme : ICMR
ID : IIRPIG-2023-0137
Informations de copyright
© 2024 Wiley Periodicals LLC.
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