(Heteroarylmethyl)benzoic Acids as a New Class of Bacterial Cystathionine γ-Lyase Inhibitors: Synthesis, Biological Evaluation, and Molecular Modeling.

MRSA antibiotic potentiator antimicrobial resistance bCSE biologically active molecules indole derivatives sepsis

Journal

ACS infectious diseases
ISSN: 2373-8227
Titre abrégé: ACS Infect Dis
Pays: United States
ID NLM: 101654580

Informations de publication

Date de publication:
21 May 2024
Historique:
medline: 21 5 2024
pubmed: 21 5 2024
entrez: 21 5 2024
Statut: aheadofprint

Résumé

Antibiotic resistance is one of the most serious global health threats. Therefore, there is a need to develop antimicrobial agents with new mechanisms of action. Targeting of bacterial cystathionine γ-lyase (bCSE), an enzyme essential for bacterial survival, is a promising approach to overcome antibiotic resistance. Here, we described a series of (heteroarylmethyl)benzoic acid derivatives and evaluated their ability to inhibit bCSE or its human ortholog hCSE using known bCSE inhibitor NL2 as a lead compound. Derivatives bearing the 6-bromoindole group proved to be the most active, with IC

Identifiants

DOI: 10.1021/acsinfecdis.4c00136 PMID: 38771206
pubmed: 38771206
doi: 10.1021/acsinfecdis.4c00136
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Auteurs

Anastasia Golovina (A)

Sirius University of Science and Technology, Olympic Avenue, 1, Sirius , Krasnodar Region 354340, Russia.
ORCID: 0000-0002-4991-0377

Eleonora Proia (E)

Rome Center for Molecular Design, Department of Drug Chemistry and Technologies, Sapienza University of Rome, P. le A. Moro 5 , Rome 00185, Italy.

Francesco Fiorentino (F)

Department of Drug Chemistry and Technologies, Sapienza University of Rome, P. le A. Moro 5, Rome 00185, Italy.
ORCID: 0000-0003-3550-1860

Maxim Yunin (M)

Sirius University of Science and Technology, Olympic Avenue, 1, Sirius , Krasnodar Region 354340, Russia.
ORCID: 0000-0002-6866-8934

Maria Kasatkina (M)

Sirius University of Science and Technology, Olympic Avenue, 1, Sirius , Krasnodar Region 354340, Russia.

Nailya Zigangirova (N)

National Research Centre of Epidemiology and Microbiology named after N. F. Gamaleya, Russian Health Ministry, Gamaleya St.18 , 123098 Moscow, Russia.

Anna Soloveva (A)

National Research Centre of Epidemiology and Microbiology named after N. F. Gamaleya, Russian Health Ministry, Gamaleya St.18 , 123098 Moscow, Russia.

Elena Sysolyatina (E)

National Research Centre of Epidemiology and Microbiology named after N. F. Gamaleya, Russian Health Ministry, Gamaleya St.18 , 123098 Moscow, Russia.

Svetlana Ermolaeva (S)

National Research Centre of Epidemiology and Microbiology named after N. F. Gamaleya, Russian Health Ministry, Gamaleya St.18 , 123098 Moscow, Russia.

Roman Novikov (R)

Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences, 32 Vavilov St. , Moscow 119991, Russia.
ORCID: 0000-0002-3740-7424

Sergei Silonov (S)

Sirius University of Science and Technology, Olympic Avenue, 1, Sirius , Krasnodar Region 354340, Russia.
Laboratory of Structural Dynamics, Stability and Folding of Proteins, Institute of Cytology, Russian Academy of Sciences, 4 Tikhoretsky Avenue , St. Petersburg 194064, Russia.

Sergei Pushkin (S)

Sirius University of Science and Technology, Olympic Avenue, 1, Sirius , Krasnodar Region 354340, Russia.

Milan Mladenović (M)

Kragujevac Center for Computational Biochemistry, Department of Chemistry, Faculty of Science, University of Kragujevac, Radoja Domanovića 12 , Kragujevac 34000, P.O. Box 60, Serbia.
ORCID: 0000-0002-6556-8778

Julia Isakova (J)

Sirius University of Science and Technology, Olympic Avenue, 1, Sirius , Krasnodar Region 354340, Russia.

Albina Belik (A)

Sirius University of Science and Technology, Olympic Avenue, 1, Sirius , Krasnodar Region 354340, Russia.

Maxim Nawrozkij (M)

Sirius University of Science and Technology, Olympic Avenue, 1, Sirius , Krasnodar Region 354340, Russia.

Dante Rotili (D)

Department of Drug Chemistry and Technologies, Sapienza University of Rome, P. le A. Moro 5, Rome 00185, Italy.
ORCID: 0000-0002-8428-8763

Rino Ragno (R)

Rome Center for Molecular Design, Department of Drug Chemistry and Technologies, Sapienza University of Rome, P. le A. Moro 5 , Rome 00185, Italy.
ORCID: 0000-0001-5399-975X

Roman Ivanov (R)

Sirius University of Science and Technology, Olympic Avenue, 1, Sirius , Krasnodar Region 354340, Russia.

Classifications MeSH