How Clot Composition Influences Fibrinolysis in the Acute Phase of Stroke: A Proteomic Study of Cerebral Thrombi.
erythrocytes
neutrophils
proteomics
stroke
thrombolytic therapy
Journal
Stroke
ISSN: 1524-4628
Titre abrégé: Stroke
Pays: United States
ID NLM: 0235266
Informations de publication
Date de publication:
Jul 2024
Jul 2024
Historique:
medline:
24
6
2024
pubmed:
21
5
2024
entrez:
21
5
2024
Statut:
ppublish
Résumé
The dramatic clinical improvement offered by mechanical thrombectomy raised questions about the relevance of prior intravenous thrombolysis in large-vessel occlusion strokes. Hence, studying intravenous thrombolysis susceptibility and its dependence on thrombus composition is crucial. We used an observational proteomic study of whole thrombi retrieved by mechanical thrombectomy to identify factors associated with fibrin content and fibrinolytic activity (FA). In 104 stroke patients, the thrombi proteome was established by mass spectrometry coupled to liquid chromatography. FA was estimated in clots both outside (FA FA Proteomics can offer new insights into the close relationship between thrombus composition and susceptibility to fibrinolysis, paving the way for new adjuvant therapies.
Sections du résumé
BACKGROUND
UNASSIGNED
The dramatic clinical improvement offered by mechanical thrombectomy raised questions about the relevance of prior intravenous thrombolysis in large-vessel occlusion strokes. Hence, studying intravenous thrombolysis susceptibility and its dependence on thrombus composition is crucial. We used an observational proteomic study of whole thrombi retrieved by mechanical thrombectomy to identify factors associated with fibrin content and fibrinolytic activity (FA).
METHODS
UNASSIGNED
In 104 stroke patients, the thrombi proteome was established by mass spectrometry coupled to liquid chromatography. FA was estimated in clots both outside (FA
RESULTS
UNASSIGNED
FA
CONCLUSIONS
UNASSIGNED
Proteomics can offer new insights into the close relationship between thrombus composition and susceptibility to fibrinolysis, paving the way for new adjuvant therapies.
Identifiants
pubmed: 38771990
doi: 10.1161/STROKEAHA.124.047156
doi:
Substances chimiques
Tissue Plasminogen Activator
EC 3.4.21.68
Fibrin
9001-31-4
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
1818-1829Investigateurs
Marie-Christine Alessi
(MC)
Mickael Bobot
(M)
Abdelmalek Brinet
(A)
Sonia Dagnino
(S)
Jean-Daniel Dehondt
(JD)
Silvia Di Legge
(SD)
Philippe Dory-Lautrec
(P)
Cecile Dulau-Metras
(C)
Pierre Durozard
(P)
Basile Kerleroux
(B)
Nadia Laksiri
(N)
Barbara Leclercq
(B)
Pierre Lehmann
(P)
Ellen Magoncia
(E)
Christine Manzac
(C)
Ophelie Osman
(O)
Roxane Peres
(R)
Sandra Perez
(S)
Caroline Rey
(C)
Anthony Reyre
(A)
Emmanuelle Robinet-Borgomano
(E)
Salome Snyman
(S)
Ljubica Svilar
(L)
Catherine Tardivel
(C)
Patricia Tourniaire
(P)
Sivadji Vingadalassalom
(S)