The influence of APOE
Alzheimer
ApoE
Interactome
Neuropathology
Proteomics
Tau
Journal
Acta neuropathologica
ISSN: 1432-0533
Titre abrégé: Acta Neuropathol
Pays: Germany
ID NLM: 0412041
Informations de publication
Date de publication:
21 May 2024
21 May 2024
Historique:
received:
11
03
2024
accepted:
12
05
2024
revised:
12
04
2024
medline:
22
5
2024
pubmed:
22
5
2024
entrez:
21
5
2024
Statut:
epublish
Résumé
APOE
Identifiants
pubmed: 38772917
doi: 10.1007/s00401-024-02744-8
pii: 10.1007/s00401-024-02744-8
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
91Subventions
Organisme : NIA NIH HHS
ID : P01AG060882
Pays : United States
Organisme : NIA NIH HHS
ID : P30AG066512
Pays : United States
Informations de copyright
© 2024. The Author(s).
Références
Arboleda-Velasquez J, Lopera F, O’Hare M, Delgado-Tirado S, Marino C, Chmielewska N et al (2019) Resistance to autosomal dominant Alzheimer’s disease in an APOE3 Christchurch homozygote: a case report. Nat Med 25:1680–1683. https://doi.org/10.1038/S41591-019-0611-3
doi: 10.1038/S41591-019-0611-3
pubmed: 31686034
pmcid: 6898984
Ash PEA, Lei S, Shattuck J, Boudeau S, Carlomagno Y, Medalla M et al (2021) TIA1 potentiates tau phase separation and promotes generation of toxic oligomeric tau. Proc Natl Acad Sci USA. https://doi.org/10.1073/PNAS.2014188118/-/DCSUPPLEMENTAL
doi: 10.1073/PNAS.2014188118/-/DCSUPPLEMENTAL
pubmed: 33619090
pmcid: 7936275
Askenazi M, Kavanagh T, Pires G, Ueberheide B, Wisniewski T, Drummond E (2023) Compilation of reported protein changes in the brain in Alzheimer’s disease. Nat Commun 141(14):1–15. https://doi.org/10.1038/s41467-023-40208-x
doi: 10.1038/s41467-023-40208-x
Ayyadevara S, Balasubramaniam M, Parcon PA, Barger SW, Griffin WST, Alla R et al (2016) Proteins that mediate protein aggregation and cytotoxicity distinguish Alzheimer’s hippocampus from normal controls. Aging Cell 15:924–939. https://doi.org/10.1111/ACEL.12501
doi: 10.1111/ACEL.12501
pubmed: 27448508
pmcid: 5013017
Babu JR, Geetha T, Wooten MW (2005) Sequestosome 1/p62 shuttles polyubiquitinated tau for proteasomal degradation. J Neurochem 94:192–203. https://doi.org/10.1111/J.1471-4159.2005.03181.X
doi: 10.1111/J.1471-4159.2005.03181.X
pubmed: 15953362
Bales KR, Verina T, Dodel RC, Du Y, Altstiel L, Bender M et al (1997) Lack of apolipoprotein E dramatically reduces amyloid β-peptide deposition. Nat Genet 173(17):263–264. https://doi.org/10.1038/ng1197-263
doi: 10.1038/ng1197-263
Bard JAM, Goodall EA, Greene ER, Jonsson E, Dong KC, Martin A (2018) Structure and function of the 26S proteasome. Annu Rev Biochem 87:697. https://doi.org/10.1146/ANNUREV-BIOCHEM-062917-011931
doi: 10.1146/ANNUREV-BIOCHEM-062917-011931
pubmed: 29652515
pmcid: 6422034
Benson GS, Bauer C, Hausner L, Couturier S, Lewczuk P, Peters O et al (2022) Don’t forget about tau: the effects of ApoE4 genotype on Alzheimer’s disease cerebrospinal fluid biomarkers in subjects with mild cognitive impairment-data from the Dementia competence network. J Neural Transm 129:477–486. https://doi.org/10.1007/S00702-022-02461-0
doi: 10.1007/S00702-022-02461-0
pubmed: 35061102
Betters RK, Luhmann E, Gottschalk AC, Xu Z, Shin MR, Ptak CP et al (2023) Characterization of the Tau interactome in human brain reveals isoform-dependent interaction with 14–3–3 family proteins. Neuro 10:1–11. https://doi.org/10.1523/ENEURO.0503-22.2023
doi: 10.1523/ENEURO.0503-22.2023
Blaudin de Thé FX, Lassus B, Schaler AW, Fowler SL, Goulbourne CN, Jeggo R et al (2021) P62 accumulates through neuroanatomical circuits in response to tauopathy propagation. Acta Neuropathol Commun. https://doi.org/10.1186/S40478-021-01280-W
doi: 10.1186/S40478-021-01280-W
pubmed: 34727983
pmcid: 8561893
Boyles JK, Pitas RE, Wilson E, Mahley RW, Taylor JM (1985) Apolipoprotein E associated with astrocytic glia of the central nervous system and with nonmyelinating glia of the peripheral nervous system. J Clin Invest 76:1501–1513. https://doi.org/10.1172/JCI112130
doi: 10.1172/JCI112130
pubmed: 3932467
pmcid: 424114
Braak H, Braak E (1991) Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol 82:239–259
doi: 10.1007/BF00308809
pubmed: 1759558
Brecht WJ, Harris FM, Chang S, Tesseur I, Yu GQ, Xu Q et al (2004) Neuron-specific apolipoprotein e4 proteolysis is associated with increased tau phosphorylation in brains of transgenic mice. J Neurosci 24:2527–2534. https://doi.org/10.1523/JNEUROSCI.4315-03.2004
doi: 10.1523/JNEUROSCI.4315-03.2004
pubmed: 15014128
pmcid: 6729489
Brion JP, Passareiro H, Nunez J, Flament-Durand J (1985) Mise en évidence immunologique de la protéine Tau au niveau des lésions de dégénérescence neurofibrillaire de la maladie d’Alzheimer. Arch Biol (Bruxelles) 95:229–235
Castellano JM, Kim J, Stewart FR, Jiang H, DeMattos RB, Patterson BW et al (2011) Human apoE isoforms differentially regulate brain amyloid-β peptide clearance. Sci Transl Med. https://doi.org/10.1126/SCITRANSLMED.3002156/SUPPL_FILE/3-89RA57_SM.PDF
doi: 10.1126/SCITRANSLMED.3002156/SUPPL_FILE/3-89RA57_SM.PDF
pubmed: 21715678
pmcid: 3192364
Clavaguera F, Bolmont T, Crowther RAA, Abramowski D, Frank S, Probst A et al (2009) Transmission and spreading of tauopathy in transgenic mouse brain. Nat Cell Biol 11:909–913. https://doi.org/10.1038/ncb1901
doi: 10.1038/ncb1901
pubmed: 19503072
pmcid: 2726961
Conrad C, Zhu J, Conrad C, Schoenfeld D, Fang Z, Ingelsson M et al (2007) Single molecule profiling of tau gene expression in Alzheimer’s disease. J Neurochem 103:1228–1236. https://doi.org/10.1111/J.1471-4159.2007.04857.X
doi: 10.1111/J.1471-4159.2007.04857.X
pubmed: 17727636
Corder E, Saunders A, Risch N, Strittmatter W, Schmechep D, Gaskell P et al (1994) Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease. Nat Gen 7:180–184
doi: 10.1038/ng0694-180
Corder E, Saunders A, Strittmatter W, Schmechel D, Gaskell P, Small G et al (1993) Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer’s disease in late onset families. Science (80-) 261:921–923
doi: 10.1126/science.8346443
D’Souza I, Schellenberg GD (2006) Arginine/serine-rich protein interaction domain-dependent modulation of a tau exon 10 splicing enhancer: altered interactions and mechanisms for functionally antagonistic FTDP-17 mutations Delta280K AND N279K. J Biol Chem 281:2460–2469. https://doi.org/10.1074/JBC.M505809200
doi: 10.1074/JBC.M505809200
pubmed: 16308321
Davies C, Tulloch J, Yip E, Currie L, Colom-Cadena M, Wegmann S et al (2023) Apolipoprotein E isoform does not influence trans-synaptic spread of tau pathology in a mouse model. Brain Neurosci Adv. https://doi.org/10.1177/23982128231191046
doi: 10.1177/23982128231191046
pubmed: 37600228
pmcid: 10433884
Delaère P, Duyckaerts C, He Y, Piette F, Hauw JJ (1991) Subtypes and differential laminar distributions of beta A4 deposits in Alzheimer’s disease: relationship with the intellectual status of 26 cases. Acta Neuropathol 81:328–335. https://doi.org/10.1007/bf00305876
doi: 10.1007/bf00305876
pubmed: 1711758
Dodart JC, Marr RA, Koistinaho M, Gregersen BM, Malkani S, Verma IM et al (2005) Gene delivery of human apolipoprotein E alters brain Aβ burden in a mouse model of Alzheimer’s disease. Proc Natl Acad Sci USA 102:1211. https://doi.org/10.1073/PNAS.0409072102
doi: 10.1073/PNAS.0409072102
pubmed: 15657137
pmcid: 544620
Drummond E, Kavanagh T, Pires G, Marta-Ariza M, Kanshin E, Nayak S et al (2022) The amyloid plaque proteome in early onset Alzheimer’s disease and Down syndrome. Acta Neuropathol Commun 101(10):1–24. https://doi.org/10.1186/S40478-022-01356-1
doi: 10.1186/S40478-022-01356-1
Drummond E, Nayak S, Pires G, Ueberheide B, Wisniewski T (2018) Isolation of amyloid plaques and neurofibrillary tangles from archived alzheimer’s disease tissue using laser-capture microdissection for downstream proteomics. Methods Mol Biol 1723:319–334. https://doi.org/10.1007/978-1-4939-7558-7_18
doi: 10.1007/978-1-4939-7558-7_18
pubmed: 29344869
pmcid: 5811767
Drummond E, Pires G, MacMurray C, Askenazi M, Nayak S, Bourdon M et al (2020) Phosphorylated tau interactome in the human Alzheimer’s disease brain. Brain 143:2803–2817. https://doi.org/10.1093/BRAIN/AWAA223
doi: 10.1093/BRAIN/AWAA223
pubmed: 32812023
pmcid: 7526722
Duyckaerts C, Delatour B, Potier M-C (2009) Classification and basic pathology of Alzheimer disease. Acta Neuropathol 118:5–36. https://doi.org/10.1007/s00401-009-0532-1
doi: 10.1007/s00401-009-0532-1
pubmed: 19381658
Duyckaerts C, Uchihara T, Seilhean D, He Y, Hauw J-J (1997) Dissociation of Alzheimer type pathology in a disconnected piece of cortex. Acta Neuropathol 93:501–507
doi: 10.1007/s004010050645
pubmed: 9144589
Eftekharzadeh B, Daigle JG, Kapinos LE, Coyne A, Schiantarelli J, Carlomagno Y et al (2018) Tau protein disrupts nucleocytoplasmic transport in alzheimer’s disease. Neuron 99:925-940.e7. https://doi.org/10.1016/J.NEURON.2018.07.039
doi: 10.1016/J.NEURON.2018.07.039
pubmed: 30189209
pmcid: 6240334
Fagan AM, Holtzman DM, Munson G, Mathur T, Schneider D, Chang LK et al (1999) Unique lipoproteins secreted by primary astrocytes from wild type, apoE (-/-), and human apoE transgenic mice. J Biol Chem 274:30001–30007. https://doi.org/10.1074/JBC.274.42.30001
doi: 10.1074/JBC.274.42.30001
pubmed: 10514484
Fryer JD, Taylor JW, DeMattos RB, Bales KR, Paul SM, Parsadanian M et al (2003) Apolipoprotein E markedly facilitates age-dependent cerebral amyloid angiopathy and spontaneous hemorrhage in amyloid precursor protein transgenic mice. J Neurosci 23:7889–7896. https://doi.org/10.1523/JNEUROSCI.23-21-07889.2003
doi: 10.1523/JNEUROSCI.23-21-07889.2003
pubmed: 12944519
pmcid: 6740607
Gärtner U, Janke C, Holzer M, Vanmechelen E, Arendt T (1998) Postmortem changes in the phosphorylation state of tau-protein in the rat brain. Neurobiol Aging 19:535–543. https://doi.org/10.1016/S0197-4580(98)00094-3
doi: 10.1016/S0197-4580(98)00094-3
pubmed: 10192212
Ginsberg SD, Che S, Counts SE, Mufson EJ (2006) Shift in the ratio of three-repeat tau and four-repeat tau mRNAs in individual cholinergic basal forebrain neurons in mild cognitive impairment and Alzheimer’s disease. J Neurochem 96:1401–1408. https://doi.org/10.1111/J.1471-4159.2005.03641.X
doi: 10.1111/J.1471-4159.2005.03641.X
pubmed: 16478530
Glenner GG, Wong CW (1984) Alzheimer’s disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem Biophys Res Commun 120:885–890. https://doi.org/10.1016/s0006-291x(84)80190-4
doi: 10.1016/s0006-291x(84)80190-4
pubmed: 6375662
Greenberg SG, Davies P, Schein JD, Binder LI (1992) Hydrofluoric acid-treated tau PHF proteins display the same biochemical properties as normal tau. J Biol Chem 267:564–569. https://doi.org/10.1016/S0021-9258(18)48531-6
doi: 10.1016/S0021-9258(18)48531-6
pubmed: 1370450
Grundke-Iqbal I, Iqbal K, Quinlan M, Tung Y, Zaidi M, Wisniewski H (1986) Microtubule-associated protein tau. A component of Alzheimer paired helical filaments. J Biol Chem 261:6084–6089
doi: 10.1016/S0021-9258(17)38495-8
pubmed: 3084478
Grundke-Iqbal I, Iqbal K, Tung YC, Quinlan M, Wisniewski HM, Binder LI (1986) Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology. 83:4913–4917. https://doi.org/10.1073/pnas.83.13.4913
Hochmair J, Exner C, Franck M, Dominguez‐Baquero A, Diez L, Brognaro H, Kraushar ML, Mielke T, Radbruch H, Kaniyappan S, Falke S, Mandelkow E, Betzel C, Wegmann S (2022) Molecular crowding and RNA synergize to promote phase separation, microtubule interaction, and seeding of Tau condensates. EMBO J https://doi.org/10.15252/EMBJ.2021108882/SUPPL_FILE/EMBJ2021108882-SUP-0002-MOVIEEV1.ZIP
Holtzman DM, Bales KR, Tenkova T, Fagan AM, Parsadanian M, Sartorius LJ et al (2000) Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer’s disease. Proc Natl Acad Sci U S A 97:2892–2897. https://doi.org/10.1073/PNAS.050004797/ASSET/63D22B0F-2005-4799-9F0A-55761F108B24/ASSETS/GRAPHIC/PQ0500047005.GIF
doi: 10.1073/PNAS.050004797/ASSET/63D22B0F-2005-4799-9F0A-55761F108B24/ASSETS/GRAPHIC/PQ0500047005.GIF
pubmed: 10694577
pmcid: 16026
Hsieh YC, Guo C, Yalamanchili HK, Abreha M, Al-Ouran R, Li Y et al (2019) Tau-mediated disruption of the spliceosome triggers cryptic RNA splicing and neurodegeneration in Alzheimer’s disease. Cell Rep 29:301-316.e10. https://doi.org/10.1016/J.CELREP.2019.08.104
doi: 10.1016/J.CELREP.2019.08.104
pubmed: 31597093
pmcid: 6919331
Inneraritys TL, Friedlander EJ, Rall SC, Weisgraber KH, Mahley RW (1983) The receptor-binding domain of human apolipoprotein E. Binding of apolipoprotein E fragments. J Biol Chem 258:12341–12347. https://doi.org/10.1016/S0021-9258(17)44180-9
doi: 10.1016/S0021-9258(17)44180-9
Kanaan NM, Hamel C, Grabinski T (2020) Combs B (2020) Liquid-liquid phase separation induces pathogenic tau conformations in vitro. Nat Commun 111(11):1–16. https://doi.org/10.1038/s41467-020-16580-3
doi: 10.1038/s41467-020-16580-3
Kavanagh T, Halder A, Drummond E (2022) Tau interactome and RNA binding proteins in neurodegenerative diseases. Mol Neurodegener. https://doi.org/10.1186/S13024-022-00572-6
doi: 10.1186/S13024-022-00572-6
pubmed: 36253823
pmcid: 9575286
Koutsodendris N, Blumenfeld J, Agrawal A, Traglia M, Grone B, Zilberter M, Yip O, Rao A, Nelson MR, Hao Y, Thomas R, Yoon SY, Arriola P, Huang Y (2023) Neuronal APOE4 removal protects against tau-mediated gliosis, neurodegeneration and myelin deficits. https://doi.org/10.1038/s43587-023-00368-3
Lester E, Van Alstyne M, McCann KL, Reddy S, Cheng LY, Kuo J et al (2023) Cytosolic condensates rich in polyserine define subcellular sites of tau aggregation. Proc Natl Acad Sci USA. https://doi.org/10.1073/PNAS.2217759120
doi: 10.1073/PNAS.2217759120
pubmed: 36626563
pmcid: 9934293
Lester E, Ooi FK, Bakkar N, Ayers J, Woerman AL, Wheeler J et al (2021) Tau aggregates are RNA-protein assemblies that mislocalize multiple nuclear speckle components. Neuron 109:1675-1691.e9. https://doi.org/10.1016/J.NEURON.2021.03.026
doi: 10.1016/J.NEURON.2021.03.026
pubmed: 33848474
pmcid: 8141031
Lin Y, McCarty J, Rauch JN, Delaney KT, Kosik KS, Fredrickson GH et al (2019) Narrow equilibrium window for complex coacervation of tau and RNA under cellular conditions. Elife. https://doi.org/10.7554/ELIFE.42571
doi: 10.7554/ELIFE.42571
pubmed: 31774399
pmcid: 6904216
Litvinchuk A, Suh JH, Guo JL, Lin K, Davis SS, Bien-Ly N et al (2023) Amelioration of Tau and ApoE4-linked glial lipid accumulation and neurodegeneration with an LXR agonist. Neuron. https://doi.org/10.1016/J.NEURON.2023.10.023
doi: 10.1016/J.NEURON.2023.10.023
pubmed: 37995685
Liu C, Song X, Nisbet R, Götz J (2016) Co-immunoprecipitation with Tau Isoform-specific antibodies reveals distinct protein interactions and highlights a putative role for 2N tau in disease. J Biol Chem 291:8173–8188. https://doi.org/10.1074/JBC.M115.641902
doi: 10.1074/JBC.M115.641902
pubmed: 26861879
pmcid: 4825019
Malek-Ahmadi M, Perez SE, Chen K, Mufson EJ (2020) Braak stage, cerebral amyloid angiopathy, and cognitive decline in early Alzheimer’s disease. J Alzheimers Dis 74:189. https://doi.org/10.3233/JAD-191151
doi: 10.3233/JAD-191151
pubmed: 31985469
pmcid: 10026689
Maziuk BF, Apicco DJ, Cruz AL, Jiang L, Ash PEA, da Rocha EL et al (2018) RNA binding proteins co-localize with small tau inclusions in tauopathy. Acta Neuropathol Commun 6:71. https://doi.org/10.1186/S40478-018-0574-5
doi: 10.1186/S40478-018-0574-5
pubmed: 30068389
pmcid: 6069705
McMillan PJ, Benbow SJ, Uhrich R, Saxton A, Baum M, Strovas T et al (2023) Tau-RNA complexes inhibit microtubule polymerization and drive disease-relevant conformation change. Brain 146:3206–3220. https://doi.org/10.1093/BRAIN/AWAD032
doi: 10.1093/BRAIN/AWAD032
pubmed: 36732296
pmcid: 10393409
Meier S, Bell M, Lyons DN, Ingram A, Chen J, Gensel JC et al (2015) Identification of novel tau interactions with endoplasmic reticulum proteins in Alzheimer’s disease brain. J Alzheimers Dis 48:687–702. https://doi.org/10.3233/JAD-150298
doi: 10.3233/JAD-150298
pubmed: 26402096
pmcid: 4881838
Montal V, Diez I, Kim CM, Orwig W, Bueichekú E, Gutiérrez-Zúñiga R et al (2022) Network Tau spreading is vulnerable to the expression gradients of APOE and glutamatergic-related genes. Sci Transl Med. https://doi.org/10.1126/SCITRANSLMED.ABN7273
doi: 10.1126/SCITRANSLMED.ABN7273
pubmed: 35895837
pmcid: 9942690
Montine TJ, Phelps CH, Beach TG, Bigio EH, Cairns NJ, Dickson DW et al (2012) National institute on aging-Alzheimer’s association guidelines for the neuropathologic assessment of Alzheimer’s disease: a practical approach. Acta Neuropathol 123:1–11. https://doi.org/10.1007/s00401-011-0910-3
doi: 10.1007/s00401-011-0910-3
pubmed: 22101365
Mori H, Kondo J, Ihara Y (1987) Ubiquitin is a component of paired helical filaments in Alzheimer’s disease. Science 235:1641–1644. https://doi.org/10.1126/SCIENCE.3029875
doi: 10.1126/SCIENCE.3029875
pubmed: 3029875
Namba Y, Tomonaga M, Kawasaki H, Otomo E, Ikeda K (1991) Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer’s disease and kuru plaque amyloid in Creutzfeldt-Jakob disease. Brain Res 541:163–166
doi: 10.1016/0006-8993(91)91092-F
pubmed: 2029618
Nelson PT, Alafuzoff I, Bigio EH, Bouras C, Braak H, Cairns NJ et al (2012) Correlation of Alzheimer disease neuropathologic changes with cognitive status: a review of the literature. J Neuropathol Exp Neurol 71:362–381
doi: 10.1097/NEN.0b013e31825018f7
pubmed: 22487856
Nichols JB, Malek-Ahmadi M, Tariot PN, Serrano GE, Sue LI, Beach TG (2021) Vascular lesions, APOE ε4, and tau pathology in Alzheimer disease. J Neuropathol Exp Neurol 80:240. https://doi.org/10.1093/JNEN/NLAA160
doi: 10.1093/JNEN/NLAA160
pubmed: 33617650
pmcid: 7899190
Ono M, Komatsu M, Ji B, Takado Y, Shimojo M, Minamihisamatsu T et al (2022) Central role for p62/SQSTM1 in the elimination of toxic tau species in a mouse model of tauopathy. Aging Cell. https://doi.org/10.1111/ACEL.13615
doi: 10.1111/ACEL.13615
pubmed: 35662390
pmcid: 9282839
Perry G, Friedman R, Shaw G, Chau V (1987) Ubiquitin is detected in neurofibrillary tangles and senile plaque neurites of Alzheimer disease brains. Proc Natl Acad Sci USA 84:3033–3036. https://doi.org/10.1073/PNAS.84.9.3033
doi: 10.1073/PNAS.84.9.3033
pubmed: 3033674
pmcid: 304795
Piatnitskaia S, Takahashi M, Kitaura H, Katsuragi Y, Kakihana T, Zhang L et al (2019) Fujii M (2019) USP10 is a critical factor for Tau-positive stress granule formation in neuronal cells. Sci Rep 91(9):1–15. https://doi.org/10.1038/s41598-019-47033-7
doi: 10.1038/s41598-019-47033-7
Pires G, McElligott S, Drusinsky S, Halliday G, Potier MC, Wisniewski T et al (2019) Secernin-1 is a novel phosphorylated tau binding protein that accumulates in Alzheimer’s disease and not in other tauopathies. Acta Neuropathol Commun. https://doi.org/10.1186/S40478-019-0848-6
doi: 10.1186/S40478-019-0848-6
pubmed: 31796108
pmcid: 6892024
Pires G, Ueberheide B, Wisniewski T, Drummond E (2023) Use of affinity purification-mass spectrometry to identify phosphorylated tau interactors in Alzheimer’s disease. Methods Mol Biol 2561:263–277. https://doi.org/10.1007/978-1-0716-2655-9_14
doi: 10.1007/978-1-0716-2655-9_14
pubmed: 36399275
Rabin JS, Nichols E, La Joie R, Casaletto KB, Palta P, Dams-O’Connor K et al (2022) Cerebral amyloid angiopathy interacts with neuritic amyloid plaques to promote tau and cognitive decline. Brain 145:2823–2833. https://doi.org/10.1093/BRAIN/AWAC178
doi: 10.1093/BRAIN/AWAC178
pubmed: 35759327
pmcid: 9420012
Rebeck WG, Reiter JS, Strickland DK, Hyman BT (1993) Apolipoprotein E in sporadic Alzheimer’s disease: allelic variation and receptor interactions. Neuron 11:575–580. https://doi.org/10.1016/0896-6273(93)90070-8
doi: 10.1016/0896-6273(93)90070-8
pubmed: 8398148
Roberts JA, Varma VR, An Y, Varma S, Candia J, Fantoni G et al (2021) A brain proteomic signature of incipient Alzheimer’s disease in young APOE ε4 carriers identifies novel drug targets. Sci Adv 7:8178. https://doi.org/10.1126/SCIADV.ABI8178
doi: 10.1126/SCIADV.ABI8178
Saito H, Dhanasekaran P, Baldwin F, Weisgraber KH, Lund-Katz S, Phillips MC (2001) Lipid binding-induced conformational change in human apolipoprotein E. Evid Two Lipid-Bound States Spher Particles. https://doi.org/10.1074/jbc.M106337200
doi: 10.1074/jbc.M106337200
Saroja SR, Gorbachev K, Tcw J, Goate AM, Pereira AC (2022) Astrocyte-secreted glypican-4 drives APOE4-dependent tau hyperphosphorylation. Proc Natl Acad Sci USA. https://doi.org/10.1073/PNAS.2108870119
doi: 10.1073/PNAS.2108870119
pubmed: 35969759
pmcid: 9407658
Schmechel DE, Saunders AM, Strittmatter WJ, Crain BJ, Hulette CM, Joo SH et al (1993) Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease. Proc Natl Acad Sci 90:9649–9653. https://doi.org/10.1073/PNAS.90.20.9649
doi: 10.1073/PNAS.90.20.9649
pubmed: 8415756
pmcid: 47627
Schmechel DE, Saunders AM, Strittmatter WJ, Crain BJ, Hulette CM, Joo SH et al (1993) Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease. Proc Natl Acad Sci U S A 90:9649. https://doi.org/10.1073/PNAS.90.20.9649
doi: 10.1073/PNAS.90.20.9649
pubmed: 8415756
pmcid: 47627
Schmidt ML, Lee VM, Trojanowski JQ (1991) Comparative epitope analysis of neuronal cytoskeletal proteins in Alzheimer’s disease senile plaque neurites and neuropil threads. Lab Invest 64:352–357
pubmed: 1706004
Sepulveda-Falla D, Sanchez JS, Almeida MC, Boassa D, Acosta-Uribe J, Vila-Castelar C et al (2022) Distinct tau neuropathology and cellular profiles of an APOE3 Christchurch homozygote protected against autosomal dominant Alzheimer’s dementia. Acta Neuropathol 144:589–601. https://doi.org/10.1007/S00401-022-02467-8
doi: 10.1007/S00401-022-02467-8
pubmed: 35838824
pmcid: 9381462
Shi Y, Yamada K, Liddelow SA, Smith ST, Zhao L, Luo W et al (2017) ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy. Nature 549:523–527. https://doi.org/10.1038/nature24016
doi: 10.1038/nature24016
pubmed: 28959956
pmcid: 5641217
Steward A, Biel D, Dewenter A, Roemer S, Wagner F, Dehsarvi A et al (2023) ApoE4 and connectivity-mediated spreading of Tau pathology at lower amyloid levels. JAMA Neurol 80:1295–1306. https://doi.org/10.1001/JAMANEUROL.2023.4038
doi: 10.1001/JAMANEUROL.2023.4038
pubmed: 37930695
Strittmatter SA, Goedert M, Weisgraber K, Dong L, Jakes R, Huang D et al (1994) Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: implications for Alzheimer disease. Proc Natl Acad Sci 91:11183–11186. https://doi.org/10.1073/PNAS.91.23.11183
doi: 10.1073/PNAS.91.23.11183
pubmed: 7972031
pmcid: 45191
Strittmatter W, Saunders A, Schmechel D, Pericak-vance M, Enghild J, Salvesen G et al (1993) Apolipoprotein E: high-avidity binding to, B-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. Proc Natl Acad Sci USA. https://doi.org/10.1073/pnas.90.5.1977
doi: 10.1073/pnas.90.5.1977
pubmed: 8415756
pmcid: 47627
Teo G, Liu G, Zhang J, Nesvizhskii AI, Gingras AC, Choi H (2014) SAINTexpress: improvements and additional features in Significance Analysis of Interactome software. J Proteom 100:37. https://doi.org/10.1016/J.JPROT.2013.10.023
doi: 10.1016/J.JPROT.2013.10.023
Terry RD, Gonatas NK, Weiss M (1964) Ultrastructural studies in Alzheimer’s presenile dementia. Am J Pathol 44:269–297
pubmed: 14119171
pmcid: 1906996
Thal DR, Ghebremedhin E, Rüb U, Yamaguchi H, Del Tredici K, Braak H (2002) Two types of sporadic cerebral amyloid angiopathy. J Neuropathol Exp Neurol 61:282–293. https://doi.org/10.1093/jnen/61.3.282
doi: 10.1093/jnen/61.3.282
pubmed: 11895043
Thal DR, Papassotiropoulos A, Saido TC, Griffin WST, Mrak RE, Kölsch H et al (2010) Capillary cerebral amyloid angiopathy identifies a distinct APOE epsilon4-associated subtype of sporadic Alzheimer’s disease. Acta Neuropathol 120:169–183. https://doi.org/10.1007/S00401-010-0707-9
doi: 10.1007/S00401-010-0707-9
pubmed: 20535486
Thal DR, Rüb U, Orantes M, Braak H (2002) Phases of Aβ-deposition in the human brain and its relevance for the development of AD. Neurology 58:1791–1800
doi: 10.1212/WNL.58.12.1791
pubmed: 12084879
Thierry M, Boluda S, Delatour B, Marty S, Seilhean D, Letournel F et al (2020) Human subiculo-fornico-mamillary system in Alzheimer’s disease: Tau seeding by the pillar of the fornix. Acta Neuropathol. https://doi.org/10.1007/s00401-019-02108-7
doi: 10.1007/s00401-019-02108-7
pubmed: 31822997
Thierry M, Marty S, Boluda S, Duyckaerts C (2017) Alzheimer’s senile plaque as shown by microcryodissection, a new technique for dissociating tissue structures. J Neural Transm 124:685–694. https://doi.org/10.1007/s00702-017-1718-7
doi: 10.1007/s00702-017-1718-7
pubmed: 28386671
Tracy TE, Madero-Pérez J, Swaney DL, Chang TS, Moritz M, Konrad C et al (2022) Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration. Cell 185:712-728.e14. https://doi.org/10.1016/J.CELL.2021.12.041
doi: 10.1016/J.CELL.2021.12.041
pubmed: 35063084
pmcid: 8857049
Wang C, Xiong M, Gratuze M, Bao X, Shi Y, Andhey PS et al (2021) Selective removal of astrocytic APOE4 strongly protects against tau-mediated neurodegeneration and decreases synaptic phagocytosis by microglia. Neuron 109:1657-1674.e7. https://doi.org/10.1016/J.NEURON.2021.03.024
doi: 10.1016/J.NEURON.2021.03.024
pubmed: 33831349
pmcid: 8141024
Wang P, Joberty G, Buist A, Vanoosthuyse A, Stancu IC, Vasconcelos B et al (2017) Tau interactome mapping based identification of Otub1 as Tau deubiquitinase involved in accumulation of pathological Tau forms in vitro and in vivo. Acta Neuropathol 133:731–749. https://doi.org/10.1007/S00401-016-1663-9
doi: 10.1007/S00401-016-1663-9
pubmed: 28083634
pmcid: 5390007
Wang Y, Balaji V, Kaniyappan S, Krüger L, Irsen S, Tepper K et al (2017) The release and trans-synaptic transmission of Tau via exosomes. Mol Neurodegener 12:5. https://doi.org/10.1186/s13024-016-0143-y
doi: 10.1186/s13024-016-0143-y
pubmed: 28086931
pmcid: 5237256
Wisniewski T, Castaño EM, Golabek A, Vogel T, Frangione B (1994) Acceleration of Alzheimer’s fibril formation by apolipoprotein E in vitro. Am J Pathol 145:1030
pubmed: 7977635
pmcid: 1887417
Wisniewski T, Drummond E (2020) APOE-amyloid interaction: therapeutic targets. Neurobiol Dis. https://doi.org/10.1016/j.nbd.2020.104784
doi: 10.1016/j.nbd.2020.104784
pubmed: 32027932
pmcid: 7118587
Wisniewski T, Frangione B (1992) Apolipoprotein E: a pathological chaperone protein in patients with cerebral and systemic amyloid. Neurosci Lett 135:235–238. https://doi.org/10.1016/0304-3940(92)90444-C
doi: 10.1016/0304-3940(92)90444-C
pubmed: 1625800
Woo JA, Yan Y, Kee TR, Cazzaro S, Percy KCMG, Wang X, Liu T, Liggett SB, Kang DE (2021) β-arrestin1 promotes tauopathy by transducing GPCR signaling, disrupting microtubules and autophagy. Life Sci Alliance https://doi.org/10.26508/LSA.202101183
Wu JW, Hussaini SA, Bastille IM, Rodriguez GA, Mrejeru A, Rilett K et al (2016) Neuronal activity enhances tau propagation and tau pathology in vivo. Nat Neurosci 19:1085–1092. https://doi.org/10.1038/nn.4328
doi: 10.1038/nn.4328
pubmed: 27322420
pmcid: 4961585
Zhang K, Daigle JG, Cunningham KM, Coyne AN, Ruan K, Grima JC et al (2018) Stress granule assembly disrupts nucleocytoplasmic transport. Cell 173:958-971.e17. https://doi.org/10.1016/J.CELL.2018.03.025
doi: 10.1016/J.CELL.2018.03.025
pubmed: 29628143
pmcid: 6083872
Zhang X, Lin Y, Eschmann NA, Zhou H, Rauch JN, Hernandez I et al (2017) RNA stores tau reversibly in complex coacervates. PLOS Biol 15:e2002183. https://doi.org/10.1371/JOURNAL.PBIO.2002183
doi: 10.1371/JOURNAL.PBIO.2002183
pubmed: 28683104
pmcid: 5500003