A pharmacokinetic model for hyperpolarized
13C
bSSFP
hyperpolarized
kPB
kPL
pharmacokinetic models
Journal
Magnetic resonance in medicine
ISSN: 1522-2594
Titre abrégé: Magn Reson Med
Pays: United States
ID NLM: 8505245
Informations de publication
Date de publication:
22 May 2024
22 May 2024
Historique:
revised:
05
04
2024
received:
10
02
2024
accepted:
16
04
2024
medline:
22
5
2024
pubmed:
22
5
2024
entrez:
22
5
2024
Statut:
aheadofprint
Résumé
Metabolite-specific balanced SSFP (MS-bSSFP) sequences are increasingly used in hyperpolarized [1- In this work, a flexible MS-bSSFP model was built that can be used to fit conversion rate constants for these experiments. The model was validated in vivo using paired animal (healthy rat kidneys n = 8, transgenic adenocarcinoma of the mouse prostate n = 3) and human renal cell carcinoma (n = 3) datasets. Gradient echo (GRE) acquisitions were used with a previous GRE model to compare to the results of the proposed GRE-bSSFP model. Within simulations, the proposed GRE-bSSFP model fits the simulated data well, whereas a GRE model shows bias because of model mismatch. For the in vivo datasets, the estimated conversion rate constants using the proposed GRE-bSSFP model are consistent with a previous GRE model. Jointly fitting the lactate T The proposed GRE-bSSFP model provides a method to estimate conversion rate constants, k
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Danmarks Grundforskningsfond
ID : DNRF124
Organisme : American Cancer Society
ID : RSG-18-005-01-CCE
Organisme : NIH HHS
ID : P41EB013598
Pays : United States
Organisme : NIH HHS
ID : R01CA249909
Pays : United States
Organisme : NIH HHS
ID : R21DK130002
Pays : United States
Organisme : NIH HHS
ID : R33HL161816
Pays : United States
Organisme : NIH HHS
ID : S10OD025077
Pays : United States
Informations de copyright
© 2024 International Society for Magnetic Resonance in Medicine.
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