Atramacrolodes A-D (1-4), Four Undescribed Eudesmane-type Sesquiterpenes from the Rhizome of Atractylodes macrocephala.

Atramacrolodes A-D * eudesmane-type sesquiterpenes * biological activities * Atractylodes macrocephala

Journal

Chemistry & biodiversity
ISSN: 1612-1880
Titre abrégé: Chem Biodivers
Pays: Switzerland
ID NLM: 101197449

Informations de publication

Date de publication:
22 May 2024
Historique:
revised: 23 04 2024
received: 30 03 2024
accepted: 14 05 2024
medline: 22 5 2024
pubmed: 22 5 2024
entrez: 22 5 2024
Statut: aheadofprint

Résumé

Four undescribed sesquiterpenes, atramacrolodes A-D (1-4), along with six known compounds 5-10 were isolated from the rhizome of Atractylodes macrocephala. Compound 3 possessed a new skeleton based on an unprecedented carton-carton connection. Their structures were determined by UV, IR, HRESIMS, NMR spectra, 13C NMR calculation with DP4+ analysis, and the comparison of experimental and calculated ECD spectra. Compounds 5 and 8 showed protective effects against paracetamol-induced liver cell injury.

Identifiants

DOI: 10.1002/cbdv.202400817 PMID: 38775105
pubmed: 38775105
doi: 10.1002/cbdv.202400817
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e202400817

Informations de copyright

© 2024 Wiley‐VCH GmbH.

Auteurs

Chuang-Jun Li (CJ)

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Medicinal chemistry, 1 Xian Nong Tan Street , Not Available, 100050, Beijing, CHINA.

Bei Li (B)

Chinese Academy of Medical Sciences & Peking Union Medical College, Institute of Materia Medica, I Xiannongtan Street, Xicheng District, Beijing 100050, P.R. China, 100050, Beijing, CHINA.

Yulu Tian (Y)

Chinese Academy of Medical Sciences & Peking Union Medical College, Institute of Materia Medica, I Xiannongtan Street, Xicheng District, Beijing 100050, P.R. China, 100050, Beijing, CHINA.

Xinyi Guo (X)

Chinese Academy of Medical Sciences and Peking Union Medical College, Institute of Materia Medica, I Xiannongtan Street, Xicheng District, Beijing 100050, P.R. China, 100050, Beijing, CHINA.

Yating Ren (Y)

Chinese Academy of Medical Sciences & Peking Union Medical College, Institute of Materia Medica, I Xiannongtan Street, Xicheng District, Beijing 100050, P.R. China, 100050, Beijing, CHINA.

Jie Ma (J)

Chinese Academy of Medical Sciences and Peking Union Medical College, Institute of Materia Medica, I Xiannongtan Street, Xicheng District, Beijing 100050, P.R. China, 100050, Beijing, CHINA.

Yingda Zang (Y)

Chinese Academy of Medical Sciences & Peking Union Medical College, Institute of Materia Medica, I Xiannongtan Street, Xicheng District, Beijing 100050, P.R. China, 100050, Beijing, CHINA.

Hua Sun (H)

Chinese Academy of Medical Sciences & Peking Union Medical College, Institute of Materia Medica, I Xiannongtan Street, Xicheng District, Beijing 100050, P.R. China, 100050, Beijing, CHINA.

Dongming Zhang (D)

Chinese Academy of Medical Sciences & Peking Union Medical College, Institute of Materia Medica, I Xiannongtan Street, Xicheng District, Beijing 100050, P.R. China, 100050, Beijing, CHINA.

Classifications MeSH