High common-γ cytokine receptor levels promote expression of Interleukin-2/Interleukin-7 receptor α-chains with implications on T-cell differentiation and function.
CD127
CD132
CD25
IL‐2 receptor α‐chain
IL‐7 receptor α‐chain
T‐cell activation
common‐γ receptor chain
lentiviral transduction
type 1 diabetes
Journal
Immunology
ISSN: 1365-2567
Titre abrégé: Immunology
Pays: England
ID NLM: 0374672
Informations de publication
Date de publication:
22 May 2024
22 May 2024
Historique:
received:
09
02
2024
accepted:
03
05
2024
medline:
23
5
2024
pubmed:
23
5
2024
entrez:
23
5
2024
Statut:
aheadofprint
Résumé
Cytokines of the common-γ receptor chain (γ
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : JA 1479/9-1
Informations de copyright
© 2024 The Authors. Immunology published by John Wiley & Sons Ltd.
Références
Rochman Y, Spolski R, Leonard WJ. New insights into the regulation of T cells by gamma(c) family cytokines. Nat Rev Immunol. 2009;9(7):480–490.
Waickman AT, Park JY, Park JH. The common gamma‐chain cytokine receptor: tricks‐and‐treats for T cells. Cell Mol Life Sci. 2016;73(2):253–269.
Mazzucchelli R, Durum SK. Interleukin‐7 receptor expression: intelligent design. Nat Rev Immunol. 2007;7(2):144–154.
Hong C, Luckey MA, Ligons DL, Waickman AT, Park JY, Kim GY, et al. Activated T cells secrete an alternatively spliced form of common gamma‐chain that inhibits cytokine signaling and exacerbates inflammation. Immunity. 2014;40(6):910–923.
Dooms H. Interleukin‐7: fuel for the autoimmune attack. J Autoimmun. 2013;45:40–48.
Gupta S, Cerosaletti K, Long SA. Renegade homeostatic cytokine responses in T1D: drivers of regulatory/effector T cell imbalance. Clin Immunol. 2014;151(2):146–154.
Deshpande P, Cavanagh MM, Le Saux S, Singh K, Weyand CM, Goronzy JJ. IL‐7‐ and IL‐15‐mediated TCR sensitization enables T cell responses to self‐antigens. J Immunol. 2013;190(4):1416–1423.
Seyfarth J, Mutze N, Antony Cruz J, Kummer S, Reinauer C, Mayatepek E, et al. CD4(+) T‐cells with high common gamma chain expression and disturbed cytokine production are enriched in children with Type‐1 diabetes. Front Immunol. 2019;10:820.
Monti P, Brigatti C, Heninger AK, Scirpoli M, Bonifacio E. Disengaging the IL‐2 receptor with daclizumab enhances IL‐7‐mediated proliferation of CD4(+) and CD8(+) T cells. Am J Transplant. 2009;9(12):2727–2735.
Guler A, Lopez Venegas M, Adankwah E, Mayatepek E, Nausch N, Jacobsen M. Suppressor of cytokine signalling 3 is crucial for interleukin‐7 receptor re‐expression after T‐cell activation and interleukin‐7 dependent proliferation. Eur J Immunol. 2019;50:234–244.
Guler A, Lopez Venegas M, Adankwah E, Mayatepek E, Nausch N, Jacobsen M. Suppressor of cytokine signalling 3 is crucial for interleukin‐7 receptor re‐expression after T‐cell activation and interleukin‐7 dependent proliferation. Eur J Immunol. 2020;50(2):234–244.
Kleinsteuber K, Heesch K, Schattling S, Sander‐Juelch C, Mock U, Riecken K, et al. SOCS3 promotes interleukin‐17 expression of human T cells. Blood. 2012;120(22):4374–4382.
Gonnord P, Angermann BR, Sadtler K, Gombos E, Chappert P, Meier‐Schellersheim M, et al. A hierarchy of affinities between cytokine receptors and the common gamma chain leads to pathway cross‐talk. Sci Signal. 2018;11(524).
Waickman AT, Keller HR, Kim TH, Luckey MA, Tai X, Hong C, et al. The cytokine receptor IL‐7Ralpha impairs IL‐2 receptor signaling and constrains the in vitro differentiation of Foxp3(+). Treg Cells iScience. 2020;23(8):101421.
McElroy CA, Holland PJ, Zhao P, Lim JM, Wells L, Eisenstein E, et al. Structural reorganization of the interleukin‐7 signaling complex. Proc Natl Acad Sci USA. 2012;109(7):2503–2508.
Cai T, Lenoir Capello R, Pi X, Wu H, Chou JJ. Structural basis of gamma chain family receptor sharing at the membrane level. Science. 2023;381(6657):569–576.
Henriques CM, Rino J, Nibbs RJ, Graham GJ, Barata JT. IL‐7 induces rapid clathrin‐mediated internalization and JAK3‐dependent degradation of IL‐7Ralpha in T cells. Blood. 2010;115(16):3269–3277.
Ponce LF, Garcia‐Martinez K, Leon K. Quantitative contribution of IL2Rgamma to the dynamic formation of IL2‐IL2R complexes. PLoS One. 2016;11(5):e0155684.
Orr SJ, Roessler S, Quigley L, Chan T, Ford JW, O'Connor GM, et al. Implications for gene therapy‐limiting expression of IL‐2R gamma c delineate differences in signaling thresholds required for lymphocyte development and maintenance. J Immunol. 2010;185(3):1393–1403.
Smyth CM, Ginn SL, Deakin CT, Logan GJ, Alexander IE. Limiting gammac expression differentially affects signaling via the interleukin (IL)‐7 and IL‐15 receptors. Blood. 2007;110(1):91–98.
Hechinger AK, Smith BA, Flynn R, Hanke K, McDonald‐Hyman C, Taylor PA, et al. Therapeutic activity of multiple common gamma‐chain cytokine inhibition in acute and chronic GVHD. Blood. 2015;125(3):570–580.
Maier LM, Lowe CE, Cooper J, Downes K, Anderson DE, Severson C, et al. IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin‐2 receptor production. PLoS Genet. 2009;5(1):e1000322.
Nishio J, Kohsaka H, Shimamura T, Hamuro J, Miyasaka N. Abundant expression of common cytokine receptor gamma chain (CD132) in rheumatoid joints. J Rheumatol. 2001;28(2):240–244.
Smith MD. Abundant expression of common cytokine receptor chain (CD132) in rheumatoid joints. J Rheumatol. 2001;28(11):2561–2563.