A retrospective review of gram-negative spinal infections in a single tertiary spinal centre over six years.
Journal
Bone & joint open
ISSN: 2633-1462
Titre abrégé: Bone Jt Open
Pays: England
ID NLM: 101770336
Informations de publication
Date de publication:
23 May 2024
23 May 2024
Historique:
medline:
23
5
2024
pubmed:
23
5
2024
entrez:
23
5
2024
Statut:
epublish
Résumé
Gram-negative infections are associated with comorbid patients, but outcomes are less well understood. This study reviewed diagnosis, management, and treatment for a cohort treated in a tertiary spinal centre. A retrospective review was performed of all gram-negative spinal infections (n = 32; median age 71 years; interquartile range 60 to 78), excluding surgical site infections, at a single centre between 2015 to 2020 with two- to six-year follow-up. Information regarding organism identification, antibiotic regime, and treatment outcomes (including clinical, radiological, and biochemical) were collected from clinical notes. All patients had comorbidities and/or non-spinal procedures within the previous year. Most infections affected lumbar segments (20/32), with This is the largest published cohort of gram-negative spinal infections. In older patients with comorbidities and/or previous interventions in the last year, a high level of suspicion must be given to gram-negative infection with blood cultures and biopsy essential. Early organism identification permits targeted treatment and good initial clinical outcomes; however, mortality is 50% in this cohort at a mean of 4.2 years (2 to 6) after diagnosis.
Identifiants
pubmed: 38778778
doi: 10.1302/2633-1462.55.BJO-2024-0001.R1
pii: BJO-2024-0001.R1
doi:
Types de publication
Journal Article
Langues
eng
Pagination
435-443Informations de copyright
© 2024 Tadross et al.
Déclaration de conflit d'intérêts
L. M. Breakwell discloses being an invited speaker to the Stryker Spinal Deformity Course 2023; and holding a leadership or fiduciary role for the British Scoliosis Society, which are unrelated to this paper. A. A. Cole declares being chief investigator for the National Institute for Health and Care Research Health Technology Assessment grant for bracing in adolescent idiopathic scoliosis (NIHR131081); being on the Spinal Expert Advisory board for the Medicines and Healthcare products Regulatory Agency, and member of Spinal ODEP/Beyond Compliance committee; and being past president of the British Scoliosis Society, British Spine Registry Deputy Lead for the British Association of Spine Surgeons, and Spinal Chair for Orthopaedic Expert Working Group for National Casemix Office, all of which are unrelated to this work.
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