Repeat Peptide Receptor Radionuclide Therapy in Neuroendocrine Tumors: A NET Center of Excellence Experience.

Neuroendocrine neoplasms Neuroendocrine tumors Peptide receptor radionuclide therapy

Journal

Journal of gastrointestinal cancer
ISSN: 1941-6636
Titre abrégé: J Gastrointest Cancer
Pays: United States
ID NLM: 101479627

Informations de publication

Date de publication:
23 May 2024
Historique:
accepted: 05 05 2024
medline: 23 5 2024
pubmed: 23 5 2024
entrez: 23 5 2024
Statut: aheadofprint

Résumé

The available data for the safety and efficacy of repeat peptide receptor radionuclide therapy (PRRT) are almost exclusively from European centers. We present an updated experience with repeat PRRT in a cohort of US patients with neuroendocrine tumors (NETs) at our NET center of excellence. We used our single-center longitudinal NET registry to identify patients who had been previously treated with at least one dose of PRRT (PRRT 1, either A total of 11 patients were included in the analysis. 45.5% (5/11) of patients received We show that repeat PRRT may benefit select patients and have an acceptable safety profile. In our cohort, PFS was significantly lower after PRRT2 as compared to PRRT1.

Identifiants

pubmed: 38780680
doi: 10.1007/s12029-024-01065-z
pii: 10.1007/s12029-024-01065-z
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

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Auteurs

Udhayvir S Grewal (US)

Division of Hematology, Oncology, and Blood and Marrow Transplantation, University of Iowa Hospitals and Clinics, Iowa City, IA, USA.
University of Iowa Holden Comprehensive Cancer Center, Iowa City, IA, USA.

Bradley T Loeffler (BT)

University of Iowa Holden Comprehensive Cancer Center, Iowa City, IA, USA.

Alexander Paschke (A)

Department of Internal Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA, USA.

Joseph S Dillon (JS)

University of Iowa Holden Comprehensive Cancer Center, Iowa City, IA, USA.
Division of Endocrinology and Metabolism, University of Iowa Hospitals and Clinics, Iowa City, IA, USA.
Holden Comprehensive Cancer Center, ENETS Center of Excellence, Iowa City, IA, USA.

Chandrikha Chandrasekharan (C)

Division of Hematology, Oncology, and Blood and Marrow Transplantation, University of Iowa Hospitals and Clinics, Iowa City, IA, USA. chandrikha-chandrasekharan@uiowa.edu.
University of Iowa Holden Comprehensive Cancer Center, Iowa City, IA, USA. chandrikha-chandrasekharan@uiowa.edu.
Holden Comprehensive Cancer Center, ENETS Center of Excellence, Iowa City, IA, USA. chandrikha-chandrasekharan@uiowa.edu.

Classifications MeSH