Prevention at home in older persons with (pre-)frailty: analysis of participants' recruitment and characteristics of the randomized controlled PromeTheus trial.
(pre)frailty
Community-dwelling
Prevention
Recruitment
Journal
Aging clinical and experimental research
ISSN: 1720-8319
Titre abrégé: Aging Clin Exp Res
Pays: Germany
ID NLM: 101132995
Informations de publication
Date de publication:
23 May 2024
23 May 2024
Historique:
received:
03
03
2024
accepted:
10
05
2024
medline:
23
5
2024
pubmed:
23
5
2024
entrez:
23
5
2024
Statut:
epublish
Résumé
The "PromeTheus" trial is evaluating a home-based, multifactorial, interdisciplinary prevention program for community-dwelling (pre-)frail older adults. These individuals often suffer from reduced participation, which can complicate the recruitment and enrollment in a clinical trial. The aim of this study was to evaluate different recruitment strategies and differences in participant characteristics in relation to these strategies. This cross-sectional study used baseline data from the randomized-controlled PromeTheus trial, in which community-dwelling (pre-)frail older persons (Clinical Frailty Scale [CFS] 4-6 pt., ≥ 70 years) were recruited via general practitioners ("GP recruitment") or flyers, newspaper articles, and personalized letters ("direct recruitment"). Differences in the sociodemographic, clinical, physical, functional, mobility-related, psychological and social characteristics were analyzed in relation to the recruitment strategy. A total of 385 participants (mean age = 81.2, SD 5.9 years; women: n = 283, 73.5%) were enrolled, of which 60 (16%) were recruited by GPs and 325 (84%) through direct recruitment. Participants recruited via GPs had significantly higher subjective frailty levels (CFS), were more often physically frail (Fried Frailty Phenotype), and showed lower physical capacity (Short Physical Performance Battery), participation (disability component of the short version of the Late-Life Function and Disability Instrument), and life-space mobility (Life-Space Assessment) compared to those recruited via the direct approach (p = 0.002-0.026). Costs per randomized participant were 94€ for the GP recruitment strategy and €213 for the direct recruitment strategy. Different strategies may be required to successfully recruit (pre-)frail home-living older adults into preventive programs. Direct recruitment strategies, in which potential participants are directly informed about the prevention program, seem to be more promising than GP recruitment but may result in enrolment of persons with less functional impairment and higher recruitment costs. German Clinical Trials Register, DRKS00024638. Registered on March 11, 2021.
Sections du résumé
BACKGROUND
BACKGROUND
The "PromeTheus" trial is evaluating a home-based, multifactorial, interdisciplinary prevention program for community-dwelling (pre-)frail older adults. These individuals often suffer from reduced participation, which can complicate the recruitment and enrollment in a clinical trial.
AIMS
OBJECTIVE
The aim of this study was to evaluate different recruitment strategies and differences in participant characteristics in relation to these strategies.
METHODS
METHODS
This cross-sectional study used baseline data from the randomized-controlled PromeTheus trial, in which community-dwelling (pre-)frail older persons (Clinical Frailty Scale [CFS] 4-6 pt., ≥ 70 years) were recruited via general practitioners ("GP recruitment") or flyers, newspaper articles, and personalized letters ("direct recruitment"). Differences in the sociodemographic, clinical, physical, functional, mobility-related, psychological and social characteristics were analyzed in relation to the recruitment strategy.
RESULTS
RESULTS
A total of 385 participants (mean age = 81.2, SD 5.9 years; women: n = 283, 73.5%) were enrolled, of which 60 (16%) were recruited by GPs and 325 (84%) through direct recruitment. Participants recruited via GPs had significantly higher subjective frailty levels (CFS), were more often physically frail (Fried Frailty Phenotype), and showed lower physical capacity (Short Physical Performance Battery), participation (disability component of the short version of the Late-Life Function and Disability Instrument), and life-space mobility (Life-Space Assessment) compared to those recruited via the direct approach (p = 0.002-0.026). Costs per randomized participant were 94€ for the GP recruitment strategy and €213 for the direct recruitment strategy.
CONCLUSION
CONCLUSIONS
Different strategies may be required to successfully recruit (pre-)frail home-living older adults into preventive programs. Direct recruitment strategies, in which potential participants are directly informed about the prevention program, seem to be more promising than GP recruitment but may result in enrolment of persons with less functional impairment and higher recruitment costs.
TRIAL REGISTRATION
BACKGROUND
German Clinical Trials Register, DRKS00024638. Registered on March 11, 2021.
Identifiants
pubmed: 38780837
doi: 10.1007/s40520-024-02775-x
pii: 10.1007/s40520-024-02775-x
doi:
Banques de données
DRKS
['DRKS00024638']
Types de publication
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
120Subventions
Organisme : Innovationsausschuss beim Gemeinsamen Bundesausschuss, G-BA
ID : 01NVF19020
Organisme : Innovationsausschuss beim Gemeinsamen Bundesausschuss, G-BA
ID : 01NVF19020
Organisme : Innovationsausschuss beim Gemeinsamen Bundesausschuss, G-BA
ID : 01NVF19020
Organisme : Innovationsausschuss beim Gemeinsamen Bundesausschuss, G-BA
ID : 01NVF19020
Organisme : Innovationsausschuss beim Gemeinsamen Bundesausschuss, G-BA
ID : 01NVF19020
Organisme : Innovationsausschuss beim Gemeinsamen Bundesausschuss, G-BA
ID : 01NVF19020
Organisme : Innovationsausschuss beim Gemeinsamen Bundesausschuss, G-BA
ID : 01NVF19020
Organisme : Innovationsausschuss beim Gemeinsamen Bundesausschuss, G-BA
ID : 01NVF19020
Organisme : Innovationsausschuss beim Gemeinsamen Bundesausschuss, G-BA
ID : 01NVF19020
Organisme : Innovationsausschuss beim Gemeinsamen Bundesausschuss, G-BA
ID : 01NVF19020
Informations de copyright
© 2024. The Author(s).
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