Molecular basis for antibody recognition of multiple drug-peptide/MHC complexes.

Humans Peptides / immunology HLA Antigens / immunology Major Histocompatibility Complex / immunology Haptens / immunology Protein Binding Cryoelectron Microscopy
TCR mimic covalent inhibitor drug discovery immune therapy protein engineering

Journal

Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876

Informations de publication

Date de publication:
28 May 2024
Historique:
medline: 23 5 2024
pubmed: 23 5 2024
entrez: 23 5 2024
Statut: ppublish

Résumé

The HapImmune

Identifiants

DOI: 10.1073/pnas.2319029121 PMID: 38781214
pubmed: 38781214
doi: 10.1073/pnas.2319029121
doi:

Substances chimiques

Peptides 0
HLA Antigens 0
Haptens 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e2319029121

Subventions

Organisme : HHS | National Institutes of Health (NIH)
ID : R21CA246457
Organisme : HHS | National Institutes of Health (NIH)
ID : R21CA267362
Organisme : HHS | National Institutes of Health (NIH)
ID : R01CA248896

Déclaration de conflit d'intérêts

Competing interests statement:L.M. started his employment at Aethon Therapeutics after the completion of this study. B.G.N. and S.K. hold equity in Aethon Therapeutics that commercializes the technologies described in this paper. HapImmune

Auteurs

Lorenzo Maso (L)

Laura and Isaac Perlmutter Cancer Center, New York University Langone Health, New York, NY 10016.

Epsa Rajak (E)

Laura and Isaac Perlmutter Cancer Center, New York University Langone Health, New York, NY 10016.
ORCID: 0009-0006-6944-2618

Injin Bang (I)

Laura and Isaac Perlmutter Cancer Center, New York University Langone Health, New York, NY 10016.

Akiko Koide (A)

Laura and Isaac Perlmutter Cancer Center, New York University Langone Health, New York, NY 10016.
Department of Medicine, New York University School of Medicine, New York, NY 10016.

Takamitsu Hattori (T)

Laura and Isaac Perlmutter Cancer Center, New York University Langone Health, New York, NY 10016.
Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY 10016.
ORCID: 0000-0002-5502-2595

Benjamin G Neel (BG)

Laura and Isaac Perlmutter Cancer Center, New York University Langone Health, New York, NY 10016.
Department of Medicine, New York University School of Medicine, New York, NY 10016.
ORCID: 0000-0002-9589-585X

Shohei Koide (S)

Laura and Isaac Perlmutter Cancer Center, New York University Langone Health, New York, NY 10016.
Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY 10016.
ORCID: 0000-0001-5473-4358

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Molecular basis for antibody recognition of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Molecular basis for antibody recognition of...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Isoantigènes › Antigènes d'histocompatibilité › Antigènes HLA › Molecular basis for antibody recognition of...
questionsmedicales.fr › Phénomènes du système immunitaire › Phénomènes immunogénétiques › Complexe majeur d'histocompatibilité › Molecular basis for antibody recognition of...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Épitopes › Haptènes › Molecular basis for antibody recognition of...
questionsmedicales.fr › Métabolisme › Liaison aux protéines › Molecular basis for antibody recognition of...
questionsmedicales.fr › Techniques d'investigation › Microscopie électronique › Cryomicroscopie électronique › Molecular basis for antibody recognition of...