Immunotherapy in Sarcoma: Current Data and Promising Strategies.

Humans Sarcoma / therapy Immunotherapy / methods Tumor Microenvironment / immunology Immune Checkpoint Inhibitors / therapeutic use Lymphocytes, Tumor-Infiltrating / immunology

Journal

American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting
ISSN: 1548-8756
Titre abrégé: Am Soc Clin Oncol Educ Book
Pays: United States
ID NLM: 101233985

Informations de publication

Date de publication:
Jun 2024
Historique:
medline: 23 5 2024
pubmed: 23 5 2024
entrez: 23 5 2024
Statut: ppublish

Résumé

Traditionally sarcomas have been considered immunologically quiet tumours, with low tumour mutational burden (TMB) and an immunosuppressive tumour microenvironment (TME), consisting of decreased T-cell infiltration and elevated levels of H1F1α, macrophages and neutrophils.

Identifiants

DOI: 10.1200/EDBK_432234 PMID: 38781557
pubmed: 38781557
doi: 10.1200/EDBK_432234
doi:

Substances chimiques

Immune Checkpoint Inhibitors 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

e432234

Auteurs

Georgina E Wood (GE)

University College Hospital of London, London, United Kingdom.

Christian Meyer (C)

Johns Hopkins, Baltimore, MD.

Florent Petitprez (F)

The University of Edinburgh, Edinburgh, Scotland.

Sandra P D'Angelo (SP)

Memorial Sloan Kettering Cancer Center, New York, NY.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Immunotherapy in Sarcoma: Current Data and...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs du tissu conjonctif et des tissus mous › Sarcomes › Immunotherapy in Sarcoma: Current Data and...
questionsmedicales.fr › Thérapeutique › Biothérapie › Immunothérapie › Immunotherapy in Sarcoma: Current Data and...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Microenvironnement cellulaire › Microenvironnement tumoral › Immunotherapy in Sarcoma: Current Data and...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Antinéoplasiques immunologiques › Inhibiteurs de points de contrôle immunitaires › Immunotherapy in Sarcoma: Current Data and...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes TIL › Immunotherapy in Sarcoma: Current Data and...