Journal

Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531

Informations de publication

Date de publication:
23 May 2024
Historique:
medline: 24 5 2024
pubmed: 24 5 2024
entrez: 23 5 2024
Statut: aheadofprint

Résumé

Gain-of-function (GoF) variants in KCNT1 channels cause severe, drug-resistant forms of epilepsy. Quinidine is a known KCNT1 blocker, but its clinical use is limited due to severe drawbacks. To identify novel KCNT1 blockers, a homology model of human KCNT1 was built and used to screen an in-house library of compounds. Among the 20 molecules selected, five (

Identifiants

DOI: 10.1021/acs.jmedchem.4c00268 PMID: 38782404
pubmed: 38782404
doi: 10.1021/acs.jmedchem.4c00268
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Auteurs

Nunzio Iraci (N)

Department of Chemical, Biological, Pharmaceutical and Environmental Sciences (CHIBIOFARAM), University of Messina, Viale F. Stagno d'Alcontres 31, 98166 Messina, Italy.
ORCID: 0000-0002-1359-8684

Lidia Carotenuto (L)

Department of Neuroscience, Reproductive Sciences and Dentistry, University Federico II of Naples, Via S. Pansini, 5, 80131 Naples, Italy.

Tania Ciaglia (T)

Department of Pharmacy, University of Salerno, Via G. Paolo II 132, 84084 Fisciano, SA, Italy.

Giorgio Belperio (G)

Department of Science and Technology, University of Sannio, Via F. De Sanctis, 82100 Benevento, Italy.

Francesca Di Matteo (F)

Department of Pharmacy, University of Salerno, Via G. Paolo II 132, 84084 Fisciano, SA, Italy.

Ilaria Mosca (I)

Department of Medicine and Health Science Vincenzo Tiberio, University of Molise, Via C. Gazzani, 86100 Campobasso, Italy.

Giusy Carleo (G)

Department of Neuroscience, Reproductive Sciences and Dentistry, University Federico II of Naples, Via S. Pansini, 5, 80131 Naples, Italy.
ORCID: 0009-0009-7908-4369

Manuela Giovanna Basilicata (M)

Department of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", P.zza L. Miraglia 2, 80138 Naples, Italy.

Paolo Ambrosino (P)

Department of Science and Technology, University of Sannio, Via F. De Sanctis, 82100 Benevento, Italy.

Rita Turcio (R)

Department of Pharmacy, University of Salerno, Via G. Paolo II 132, 84084 Fisciano, SA, Italy.

Deborah Puzo (D)

Department of Medicine and Health Science Vincenzo Tiberio, University of Molise, Via C. Gazzani, 86100 Campobasso, Italy.

Giacomo Pepe (G)

Department of Pharmacy, University of Salerno, Via G. Paolo II 132, 84084 Fisciano, SA, Italy.
ORCID: 0000-0002-7561-2023

Isabel Gomez-Monterrey (I)

Department of Pharmacy, University Federico II of Naples, Via D. Montesano 49, 80131 Naples, Italy.
ORCID: 0000-0001-6688-2606

Maria Virginia Soldovieri (MV)

Department of Medicine and Health Science Vincenzo Tiberio, University of Molise, Via C. Gazzani, 86100 Campobasso, Italy.

Veronica Di Sarno (V)

Department of Pharmacy, University of Salerno, Via G. Paolo II 132, 84084 Fisciano, SA, Italy.

Pietro Campiglia (P)

Department of Pharmacy, University of Salerno, Via G. Paolo II 132, 84084 Fisciano, SA, Italy.
ORCID: 0000-0002-1069-2181

Francesco Miceli (F)

Department of Neuroscience, Reproductive Sciences and Dentistry, University Federico II of Naples, Via S. Pansini, 5, 80131 Naples, Italy.

Alessia Bertamino (A)

Department of Pharmacy, University of Salerno, Via G. Paolo II 132, 84084 Fisciano, SA, Italy.
ORCID: 0000-0002-5482-6276

Carmine Ostacolo (C)

Department of Pharmacy, University of Salerno, Via G. Paolo II 132, 84084 Fisciano, SA, Italy.
ORCID: 0000-0003-3715-8680

Maurizio Taglialatela (M)

Department of Neuroscience, Reproductive Sciences and Dentistry, University Federico II of Naples, Via S. Pansini, 5, 80131 Naples, Italy.
ORCID: 0000-0002-8202-0560

Classifications MeSH