The importance of murine phospho-MLKL-S345 in situ detection for necroptosis assessment in vivo.


Journal

Cell death and differentiation
ISSN: 1476-5403
Titre abrégé: Cell Death Differ
Pays: England
ID NLM: 9437445

Informations de publication

Date de publication:
23 May 2024
Historique:
received: 20 12 2023
accepted: 07 05 2024
revised: 02 05 2024
medline: 24 5 2024
pubmed: 24 5 2024
entrez: 23 5 2024
Statut: aheadofprint

Résumé

Necroptosis is a caspase-independent modality of cell death implicated in many inflammatory pathologies. The execution of this pathway requires the formation of a cytosolic platform that comprises RIPK1 and RIPK3 which, in turn, mediates the phosphorylation of the pseudokinase MLKL (S345 in mouse). The activation of this executioner is followed by its oligomerisation and accumulation at the plasma-membrane where it leads to cell death via plasma-membrane destabilisation and consequent permeabilisation. While the biochemical and cellular characterisation of these events have been amply investigated, the study of necroptosis involvement in vivo in animal models is currently limited to the use of Mlkl

Identifiants

pubmed: 38783091
doi: 10.1038/s41418-024-01313-6
pii: 10.1038/s41418-024-01313-6
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2024. The Author(s).

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Auteurs

Konstantinos Kelepouras (K)

Genome Instability, Inflammation and Cell Death Laboratory, Institute of Biochemistry I, Centre for Biochemistry, Faculty of Medicine, University of Cologne, 50931, Cologne, Germany.
Center for Molecular Medicine Cologne (CMMC), University of Cologne, 50931, Cologne, Germany.

Julia Saggau (J)

Genome Instability, Inflammation and Cell Death Laboratory, Institute of Biochemistry I, Centre for Biochemistry, Faculty of Medicine, University of Cologne, 50931, Cologne, Germany.
Center for Molecular Medicine Cologne (CMMC), University of Cologne, 50931, Cologne, Germany.
Cell Death, Inflammation and Immunity Laboratory, CECAD Cluster of Excellence, University of Cologne, 50931, Cologne, Germany.
Cell Death, Inflammation and Immunity Laboratory, Institute of Biochemistry I, Centre for Biochemistry, Faculty of Medicine, University of Cologne, 50931, Cologne, Germany.

Ana Beatriz Varanda (AB)

Cell Death, Inflammation and Immunity Laboratory, CECAD Cluster of Excellence, University of Cologne, 50931, Cologne, Germany.
Cell Death, Inflammation and Immunity Laboratory, Institute of Biochemistry I, Centre for Biochemistry, Faculty of Medicine, University of Cologne, 50931, Cologne, Germany.

Matea Zrilic (M)

Center for Molecular Medicine Cologne (CMMC), University of Cologne, 50931, Cologne, Germany.

Christine Kiefer (C)

Genome Instability, Inflammation and Cell Death Laboratory, Institute of Biochemistry I, Centre for Biochemistry, Faculty of Medicine, University of Cologne, 50931, Cologne, Germany.
Center for Molecular Medicine Cologne (CMMC), University of Cologne, 50931, Cologne, Germany.

Hassan Rakhsh-Khorshid (H)

Genome Instability, Inflammation and Cell Death Laboratory, Institute of Biochemistry I, Centre for Biochemistry, Faculty of Medicine, University of Cologne, 50931, Cologne, Germany.
Center for Molecular Medicine Cologne (CMMC), University of Cologne, 50931, Cologne, Germany.

Ina Lisewski (I)

Center for Molecular Medicine Cologne (CMMC), University of Cologne, 50931, Cologne, Germany.

Iratxe Uranga-Murillo (I)

Department of Microbiology, Radiology, Paediatry and Public Heath, Faculty of Medicine, University of Zaragoza/IIS, Aragon, Spain.
Centro de Investigacion Biomedica en Red de Enfermedades infecciosas (CIBERINFEC), Instituto de Salud Carlos III, Madrid, Spain.

Maykel Arias (M)

Department of Microbiology, Radiology, Paediatry and Public Heath, Faculty of Medicine, University of Zaragoza/IIS, Aragon, Spain.
Centro de Investigacion Biomedica en Red de Enfermedades infecciosas (CIBERINFEC), Instituto de Salud Carlos III, Madrid, Spain.

Julian Pardo (J)

Department of Microbiology, Radiology, Paediatry and Public Heath, Faculty of Medicine, University of Zaragoza/IIS, Aragon, Spain.
Centro de Investigacion Biomedica en Red de Enfermedades infecciosas (CIBERINFEC), Instituto de Salud Carlos III, Madrid, Spain.

Wulf Tonnus (W)

Division of Nephrology, Department of Internal Medicine 3, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Dresden, Germany.

Andreas Linkermann (A)

Division of Nephrology, Department of Internal Medicine 3, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Dresden, Germany.
Division of Nephrology, Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA.

Alessandro Annibaldi (A)

Center for Molecular Medicine Cologne (CMMC), University of Cologne, 50931, Cologne, Germany.

Henning Walczak (H)

Cell Death, Inflammation and Immunity Laboratory, CECAD Cluster of Excellence, University of Cologne, 50931, Cologne, Germany.
Cell Death, Inflammation and Immunity Laboratory, Institute of Biochemistry I, Centre for Biochemistry, Faculty of Medicine, University of Cologne, 50931, Cologne, Germany.
Centre for Cell Death, Cancer and Inflammation, UCL Cancer Institute, University College London, WC1E 6BT, London, UK.

Gianmaria Liccardi (G)

Genome Instability, Inflammation and Cell Death Laboratory, Institute of Biochemistry I, Centre for Biochemistry, Faculty of Medicine, University of Cologne, 50931, Cologne, Germany. Gianmaria.liccardi@uk-koeln.de.
Center for Molecular Medicine Cologne (CMMC), University of Cologne, 50931, Cologne, Germany. Gianmaria.liccardi@uk-koeln.de.

Classifications MeSH