Mullerian adenosarcoma of the uterus with MASO: a case report of cervical adenosarcoma in a young female that never had sexual behavior.
Asexual women
Cervical tumor
Mullerian adenosarcoma
Sarcomatous overgrowth
Uterine adenosarcoma
Journal
BMC women's health
ISSN: 1472-6874
Titre abrégé: BMC Womens Health
Pays: England
ID NLM: 101088690
Informations de publication
Date de publication:
23 May 2024
23 May 2024
Historique:
received:
03
08
2023
accepted:
09
05
2024
medline:
24
5
2024
pubmed:
24
5
2024
entrez:
23
5
2024
Statut:
epublish
Résumé
Cervical mullerian adenosarcoma is a rare uterine sarcoma, especially in young women. Its pathological features are low-grade malignant tumors with bidirectional differentiation, and the degree of malignancy is similar to that of low-grade endometrial stromal sarcoma. This paper reports the case of a young asexual patient who has been closely followed up after tumor resection and has not had any recurrences. A 20-year-old, young asexual woman was diagnosed with cervical mullerian adenosarcoma with sarcomatous overgrowth (MASO). Cervical tumor resection was performed after admission, and the resection margin was negative. After the operation, she refused to undergo secondary surgery due to fertility requirements and did not receive adjuvant treatment. The patient was closely followed up after the operation and has not yet relapsed. A young woman with cervical MASO did not receive adjuvant treatment after cervical tumor resection. For women with fertility requirements, close follow-ups should be conducted after the operation to guard against tumor recurrence and radical tumor resection should be performed as early as possible after the patient no longer requires their fertility.
Sections du résumé
BACKGROUND
BACKGROUND
Cervical mullerian adenosarcoma is a rare uterine sarcoma, especially in young women. Its pathological features are low-grade malignant tumors with bidirectional differentiation, and the degree of malignancy is similar to that of low-grade endometrial stromal sarcoma. This paper reports the case of a young asexual patient who has been closely followed up after tumor resection and has not had any recurrences.
CASE PRESENTATION
METHODS
A 20-year-old, young asexual woman was diagnosed with cervical mullerian adenosarcoma with sarcomatous overgrowth (MASO). Cervical tumor resection was performed after admission, and the resection margin was negative. After the operation, she refused to undergo secondary surgery due to fertility requirements and did not receive adjuvant treatment. The patient was closely followed up after the operation and has not yet relapsed.
CONCLUSION
CONCLUSIONS
A young woman with cervical MASO did not receive adjuvant treatment after cervical tumor resection. For women with fertility requirements, close follow-ups should be conducted after the operation to guard against tumor recurrence and radical tumor resection should be performed as early as possible after the patient no longer requires their fertility.
Identifiants
pubmed: 38783282
doi: 10.1186/s12905-024-03140-w
pii: 10.1186/s12905-024-03140-w
doi:
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
308Subventions
Organisme : National Natural Science Foundation of China
ID : 82160538
Informations de copyright
© 2024. The Author(s).
Références
Morales FDA, Medina RML, Trujillo LM, Beltrán MI, Dulcey IC. Müllerian adenosarcoma of the uterine cervix with sarcomatous overgrowth: a case report of aggressive disease in a young patient. Int J Surg Case Rep. 2016;27:155–61.
doi: 10.1016/j.ijscr.2016.08.044
García-Mendoza YI, Murguia-Perez M, Galván-Linares AI, et al. Case Report: Uterine Adenosarcoma with Sarcomatous overgrowth and malignant heterologous elements. Front Med (Lausanne). 2022;8:819141. Published 2022 Jan 10.
doi: 10.3389/fmed.2021.819141
pubmed: 35083260
Kudela E, Nachajova M, Balharek T, Gabonova E, Danko J. Mullerian adenosarcomas of the uterine cervix with sarcomatous overgrowth. Curr Probl Cancer. 2019;43(4):371–6.
doi: 10.1016/j.currproblcancer.2018.11.002
pubmed: 30522776
Goh C, Lin XH, Chin PS, Lim YK. Uterine preservation in a young patient with adenosarcoma of the uterus - case report and review of literature. Gynecol Oncol Rep. 2018;25:27–9. Published 2018 May 9.
doi: 10.1016/j.gore.2018.05.002
pubmed: 29977987
pmcid: 6030025
Liang J, Lin Z. FIGO cancer report 2018——interpretation of the diagnosis and treatment of uterine sarcomas. Chin J Practical Gynecol Obstet. 2018;34(12):1366–71. Chinese. https://kns.cnki.net/kcms/detail/detail.aspx?dbcode=CJFD&dbname=CJFDLAST2019&filename=ZGSF201812018&uniplatform=NZKPT&v=umM-30p-IGb_GM6uW91wvfFF67NXFjTGATPzUzcSgiWYj_aek8rtwZ-g4W8yHJzL .
Taga S, Sawada M, Nagai A, Yamamoto D, Hayase R. A case of adenosarcoma of the uterus. Case Rep Obstet Gynecol. 2014;2014:342187.
pubmed: 24592340
pmcid: 3926369
Hoang L, Chiang S, Lee CH. Endometrial stromal sarcomas and related neoplasms: new developments and diagnostic considerations. Pathology. 2018;50(2):162–77.
doi: 10.1016/j.pathol.2017.11.086
pubmed: 29275929
Zhang Y, Li Y, Huang H, et al. Low-grade endometrial stromal sarcoma and uterine adenosarcoma: a comparison of clinical manifestations and outcomes. J Cancer. 2019;10(15):3352–60. Published 2019 Jun 5.
doi: 10.7150/jca.30691
pubmed: 31293638
pmcid: 6603426
Li H, Song M, Ma X, et al. Clinical analysis of 56 cases of Mullerian adenosarcoma. Chinese Journal of Practical Gynecology and Obstetrics. 2018;34(09):1047–1050. Chinese. https://kns.cnki.net/kcms/detail/detail.aspx?dbcode=CJFD&dbname=CJFDLAST2018&filename=ZGSF201809030&uniplatform=NZKPT&v=umM-30p-IGbPN4V5PQADedF3qWHGKa1EPHHttOaZ1JQJ_2E8g6meNVFoPPAd7cbg
Wang B, Yang HD, Shi XH, Li H. Advanced uterine adenosarcoma with sarcomatous overgrowth in a young woman: a case report. Med (Baltim). 2019;98(47):e18119.
doi: 10.1097/MD.0000000000018119
Clement PB, Scully RE. Mullerian adenosarcoma of the uterus: a clinicopathologic analysis of 100 cases with a review of the literature. Hum Pathol. 1990;21(4):363–81.
doi: 10.1016/0046-8177(90)90198-E
pubmed: 2156771
Mubeen A, Shahid M, Makary R. Post-radiation mullerian adenosarcoma with sarcomatous overgrowth: rare presentation of an uncommon malignancy. Pathologica. 2020;112(4):219–23.
doi: 10.32074/1591-951X-114
pubmed: 33393526
pmcid: 8183353
Nannini M, Dondi G, Santini D, De Leo A, Dei Tos AP, Zamagni C, Saponara M, Gatto L, Nigro C, Bertaccini P, Zompatori M, De Iaco P, Perrone AM, Perrone MA, Pantaleo MA. A single-centre experience on the management of Adenosarcoma: a successful report of an Integrated Medical and Surgical Approach. Clin Med Insights Oncol. 2018;12:1179554918782477.
doi: 10.1177/1179554918782477
pubmed: 29977120
pmcid: 6024524
Bogani G, Sopracordevole F, Ciavattini A, Vizza E, Vercellini P, Giannini A, Ghezzi F, Scambia G, Raspagliesi F, Di Donato V. Italian society of Colposcopy and Cervico-Vaginal Pathology (SICPCV); the investigators of the Italian HPV study group (iHPV study group). Duration of human papillomavirus persistence and its relationship with recurrent cervical dysplasia. Eur J Cancer Prev. 2023;32(6):525–32.
doi: 10.1097/CEJ.0000000000000822
pubmed: 37401466
Bogani G, Sopracordevole F, Ciavattini A, Vizza E, Vercellini P, Ghezzi F, Scambia G, Di Donato V, Giannini A, Raspagliesi F. HPV persistence after cervical surgical excision of high-grade cervical lesions. Cancer Cytopathol. 2023 Sep 25.
Mumba E, Ali H, Turton D, Cooper K, Grayson W. Human papillomaviruses do not play an aetiological role in Müllerian adenosarcomas of the uterine cervix. J Clin Pathol. 2008;61(9):1041–4.
doi: 10.1136/jcp.2008.056614
pubmed: 18552169
Omi M, Tonooka A, Chiba T, et al. Immunohistochemical markers and the clinical course of adenosarcoma: a series of seven cases. Diagn Pathol. 2020;15(1):119. Published 2020 Sep 24.
doi: 10.1186/s13000-020-01036-5
pubmed: 32972432
pmcid: 7513510
Wang Y, Liu AJ, Chen X, Song X. Prognosis-related clinicopathologic characteristics of FIGO stage I Müllerian adenosarcoma of uterus. Zhonghua Bing Li Xue Za Zhi. 2018;47(5):334–8.
pubmed: 29783798
Hodgson A, Amemiya Y, Seth A, Djordjevic B, Parra-Herran C. High-grade Müllerian Adenosarcoma: genomic and clinicopathologic characterization of a distinct neoplasm with prevalent TP53 pathway alterations and aggressive behavior. Am J Surg Pathol. 2017;41(11):1513–22.
doi: 10.1097/PAS.0000000000000907
pubmed: 28834809
Wu Y, Fan Y, Li J, et al. Unmarried asexual life female uterus mullerian ductal gland sarcoma: case report. Chin J Family Plann Gynecotokology. 2019;11(06):91–3. Chinese. https://kns.cnki.net/kcms/detail/detail.aspx?dbcode=CJFD&dbname=CJFDLAST2019&filename=JHFC201906026&uniplatform=NZKPT&v=2K8Yz5RCR6gIp7bclE5U8yGFn154wd7bOfcpNXhmrcRsGgyt6NLTUAJUcs330DUf .
Seagle BL, Kanis M, Strohl AE, Shahabi S. Survival of women with mullerian adenosarcoma: a national cancer data base study. Gynecol Oncol. 2016;1433:636–41.
doi: 10.1016/j.ygyno.2016.10.013
Zhao Y. MRI features of uterine adenosarcoma. Journal of Nanchang University (Medical Sciences). 2021;61(01):52–56. Chinese. https://kns.cnki.net/kcms/detail/detail.aspx?dbcode=CJFD&dbname=CJFDLAST2021&filename=JXYB202101012&uniplatform=NZKPT&v=ClbNsfAzITET85UPpXBiOm8kELy2MmN50gQye76E6Z53eZDmSFiWU-BD-7hZNn_N
Nathenson MJ, Ravi V, Fleming N, Wang WL, Conley A. Uterine adenosarcoma: a review. Curr Oncol Rep. 2016;18(11):68.
doi: 10.1007/s11912-016-0552-7
pubmed: 27718181
Zizolfi B, Foreste V, Di Spiezio Sardo A, Manzi A, Bifulco G, Carugno J. Fertility sparing management of uterine adenosarcoma: case report and literature review. Facts Views Vis Obgyn. 2021;12(4):315–8. Published 2021 Jan 8.
pubmed: 33575681
pmcid: 7863688
Mandato VD, Torricelli F, Mastrofilippo V, Valli R, Aguzzoli L, La Sala GB. Primary extra-uterine and extra-ovarian mullerian adenosarcoma: case report and literature review. BMC Cancer. 2018;181:134. Published 2018 Feb 5.
doi: 10.1186/s12885-018-4037-y
Xie L, Lin R, Lin Z. Interpretation of 2022 NCCN clinical practice guide for uterine tumors (version 1). Chin J Practical Gynecol Obstet. 2021;37(12):1227–33. Chinese. https://kns.cnki.net/kcms/detail/detail.aspx?dbcode=CJFD&dbname=CJFDLAST2021&filename=ZGSF202101020&uniplatform=NZKPT&v=_uWLVYqiTg-a4l16tFTJWLKmR0rnrsmUM2hxKi0k0XXI6C_3c9kj5RbuhiZPWsRQ .
L’Heveder A, Jones BP, Saso S, et al. Conservative management of uterine adenosarcoma: lessons learned from 20 years of follow-up. Arch Gynecol Obstet. 2019;300(5):1383–9.
doi: 10.1007/s00404-019-05306-6
pubmed: 31584132
pmcid: 6814630
Schroeder B, Pollack SM, Jones RL. Systemic therapy in advanced uterine adenosarcoma with sarcomatous overgrowth. Gynecol Oncol. 2014;132(2):513.
doi: 10.1016/j.ygyno.2013.09.035
pubmed: 24333501
Pinto A, Howitt B. Uterine Adenosarcoma. Arch Pathol Lab Med. 2016;140(3):286–90.
doi: 10.5858/arpa.2014-0523-RS
pubmed: 26927725
Tanner EJ, Toussaint T, Leitao MM Jr, et al. Management of uterine adenosarcomas with and without sarcomatous overgrowth. Gynecol Oncol. 2013;129(1):140–4.
doi: 10.1016/j.ygyno.2012.12.036
pubmed: 23283300
Monti M, D’Aniello D, Scopelliti A, Tibaldi V, Santangelo G, Colagiovanni V, Giannini A, DI Donato V, Palaia I, Perniola G, Giancotti A, Muzii L. Benedetti Panici P. Relationship between cervical excisional treatment for cervical intraepithelial neoplasia and obstetrical outcome. Minerva Obstet Gynecol. 2021;73(2):233–46.
doi: 10.23736/S2724-606X.20.04678-X
pubmed: 33140628
Goh C, Lin XH, Chin PS, et al. Uterine preservation in a young patient with adenosarcoma of the uterus—case report and review of literature. Gynecol Oncol Rep. 2018;25:27–9.
doi: 10.1016/j.gore.2018.05.002
pubmed: 29977987
pmcid: 6030025
Fadavi P, Garousi M, Soltani S et al. The uterine adenosarcoma with postoperative residual in a woman treated by total abdominal hysterectomy/bilateral salpingo-oophorectomy: a case report and review of literature. Cancer Rep (Hoboken). 2023:e1891.
Wang Q, Sun S, Cai J, Yang L, Lv G, Yang Q. Uterine adenosarcoma: a case report and review of the literature. Am J Nucl Med Mol Imaging. 2023;13(2):70–6.
pubmed: 37214266
pmcid: 10193199
Dowding DD, Wayne LM, Guirguis AS. High grade uterine adenosarcoma with sarcomatous overgrowth in a young woman amenable to primary surgical reduction: a case study and literature review. Gynecol Oncol Rep. 2022;39:100920.
doi: 10.1016/j.gore.2021.100920
pubmed: 35036509
Nathenson MJ, Conley AP. Prognostic factors for uterine adenosarcoma: a review. Expert Rev Anticancer Ther. 2018;18(11):1093–100.
doi: 10.1080/14737140.2018.1518136
pubmed: 30169984
Carroll A, Ramirez PT, Westin SN, et al. Uterine adenosarcoma: an analysis on management, outcomes, and risk factors for recurrence. Gynecol Oncol. 2014;135(3):455–61.
doi: 10.1016/j.ygyno.2014.10.022
pubmed: 25449308
pmcid: 4430193
Li JY, Mutlu L, Tymon-Rosario J, et al. Clinicopathologic characteristics and oncologic outcomes in adenosarcoma of gynecologic sites. Gynecol Oncol Rep. 2021;39:100913. Published 2021 Dec 20.
doi: 10.1016/j.gore.2021.100913
pubmed: 35005157
pmcid: 8715286
Wang J, Liu Q, Deng B, et al. Clinical analysis of 16 cases of uterine adenosarcoma. Chin J Family Plann Gynecotokology. 2019;11(12):78–82. Chinese. https://kns.cnki.net/kcms/detail/detail.aspx?dbcode=CJFD&dbname=CJFDLAST2020&filename=JHFC201912022&uniplatform=NZKPT&v=2K8Yz5RCR6j-KZis42TpI_0wm27dvE5mrn5aBx0niObfl05dJJZ1v2OvJD23A7NT .