Label-free detection of prostaglandin transporter (SLCO2A1) function and inhibition: insights by wound healing and TRACT assays.

PGE2 SLCO2A1 genetic variants label-free prostaglandin transporter prostanoid receptors wound healing xCELLigence

Journal

Frontiers in pharmacology
ISSN: 1663-9812
Titre abrégé: Front Pharmacol
Pays: Switzerland
ID NLM: 101548923

Informations de publication

Date de publication:
2024
Historique:
received: 17 01 2024
accepted: 19 04 2024
medline: 24 5 2024
pubmed: 24 5 2024
entrez: 24 5 2024
Statut: epublish

Résumé

The prostaglandin transporter (PGT, SLCO2A1) mediates transport of prostanoids (a.o. prostaglandin E2 (PGE

Identifiants

DOI: 10.3389/fphar.2024.1372109 PMID: 38783936 PMC: PMC11111933
pubmed: 38783936
doi: 10.3389/fphar.2024.1372109
pii: 1372109
pmc: PMC11111933
doi:

Types de publication

Journal Article

Langues

eng

Pagination

1372109

Informations de copyright

Copyright © 2024 Mocking, van Oostveen, van Veldhoven, Minnee, Fehres, Whitehurst, IJzerman and Heitman.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Auteurs

Tamara A M Mocking (TAM)

Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research, Leiden University, Leiden, Netherlands.

Wieke M van Oostveen (WM)

Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research, Leiden University, Leiden, Netherlands.
Department of Rheumatology, Leiden University Medical Center, Leiden University, Leiden, Netherlands.
Immunology and Respiratory Diseases, Boehringer-Ingelheim, Ridgefield, CT, United States.
Oncode Institute, Leiden, Netherlands.

Jacobus P D van Veldhoven (JPD)

Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research, Leiden University, Leiden, Netherlands.
Department of Rheumatology, Leiden University Medical Center, Leiden University, Leiden, Netherlands.
Immunology and Respiratory Diseases, Boehringer-Ingelheim, Ridgefield, CT, United States.
Oncode Institute, Leiden, Netherlands.

Hugo Minnee (H)

Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research, Leiden University, Leiden, Netherlands.

Cynthia M Fehres (CM)

Department of Rheumatology, Leiden University Medical Center, Leiden University, Leiden, Netherlands.

Charles E Whitehurst (CE)

Immunology and Respiratory Diseases, Boehringer-Ingelheim, Ridgefield, CT, United States.

Adriaan P IJzerman (AP)

Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research, Leiden University, Leiden, Netherlands.

Laura H Heitman (LH)

Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research, Leiden University, Leiden, Netherlands.
Oncode Institute, Leiden, Netherlands.

Classifications MeSH