Computational design, synthesis, and assessment of 3-(4-(4-(1,3,4-oxadiazol-2-yl)-1


Journal

RSC medicinal chemistry
ISSN: 2632-8682
Titre abrégé: RSC Med Chem
Pays: England
ID NLM: 101759460

Informations de publication

Date de publication:
22 May 2024
Historique:
received: 21 01 2024
accepted: 25 02 2024
pmc-release: 11 04 2025
medline: 24 5 2024
pubmed: 24 5 2024
entrez: 24 5 2024
Statut: epublish

Résumé

The epidermal growth factor receptor (EGFR) enzyme plays a critical role in governing the cell cycle, positioning it as a promising target for the development of anticancer drugs. In this study, we endeavored to design and synthesize innovative EGFR inhibitors with potential applications in anticancer therapy. A novel series of compounds, namely 3-(4-(4-(1,3,4-oxadiazol-2-yl)-1

Identifiants

pubmed: 38784476
doi: 10.1039/d4md00055b
pii: d4md00055b
pmc: PMC11110788
doi:

Types de publication

Journal Article

Langues

eng

Pagination

1626-1639

Informations de copyright

This journal is © The Royal Society of Chemistry.

Déclaration de conflit d'intérêts

The authors declare no conflict of interest.

Auteurs

Nilesh Raghunath Khedkar (NR)

Novel Drug Discovery & Development, Lupin Research Park, Lupin Ltd. Pune-412115 India milindsindkhedkar@lupin.com.

Milind Sindkhedkar (M)

Novel Drug Discovery & Development, Lupin Research Park, Lupin Ltd. Pune-412115 India milindsindkhedkar@lupin.com.

Alex Joseph (A)

Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, Manipal, Academy of Higher Education Manipal Karnataka-576104 India.

Classifications MeSH