SNP-Associated Substitutions of Amino Acid Residues in the dNTP Selection Subdomain Decrease Polβ Polymerase Activity.

DNA Polymerase beta / metabolism Polymorphism, Single Nucleotide Humans Amino Acid Substitution Molecular Dynamics Simulation Kinetics DNA Repair / genetics Nucleotides / metabolism
DNA polymerase beta DNA repair enzymatic activity single-nucleotide polymorphism

Journal

Biomolecules
ISSN: 2218-273X
Titre abrégé: Biomolecules
Pays: Switzerland
ID NLM: 101596414

Informations de publication

Date de publication:
02 May 2024
Historique:
received: 27 03 2024
revised: 18 04 2024
accepted: 30 04 2024
medline: 24 5 2024
pubmed: 24 5 2024
entrez: 24 5 2024
Statut: epublish

Résumé

In the cell, DNA polymerase β (Polβ) is involved in many processes aimed at maintaining genome stability and is considered the main repair DNA polymerase participating in base excision repair (BER). Polβ can fill DNA gaps formed by other DNA repair enzymes. Single-nucleotide polymorphisms (SNPs) in the

Identifiants

DOI: 10.3390/biom14050547 PMID: 38785954
pubmed: 38785954
pii: biom14050547
doi: 10.3390/biom14050547
pii:
doi:

Substances chimiques

DNA Polymerase beta EC 2.7.7.7
POLB protein, human EC 2.7.7.7
Nucleotides 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Russian Science Foundation
ID : No. 21-74-10103
Organisme : Russian Ministry of Science and Higher Education
ID : 121031300041-4

Auteurs

Olga A Kladova (OA)

Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of Russian Academy of Sciences, 630090 Novosibirsk, Russia.

Timofey E Tyugashev (TE)

Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of Russian Academy of Sciences, 630090 Novosibirsk, Russia.
ORCID: 0000-0002-2539-2894

Aleksandr A Miroshnikov (AA)

Department of Natural Sciences, Novosibirsk State University, 630090 Novosibirsk, Russia.

Daria S Novopashina (DS)

Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of Russian Academy of Sciences, 630090 Novosibirsk, Russia.
ORCID: 0000-0001-6082-6785

Nikita A Kuznetsov (NA)

Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of Russian Academy of Sciences, 630090 Novosibirsk, Russia.
Department of Natural Sciences, Novosibirsk State University, 630090 Novosibirsk, Russia.
ORCID: 0000-0002-4016-198X

Aleksandra A Kuznetsova (AA)

Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of Russian Academy of Sciences, 630090 Novosibirsk, Russia.
ORCID: 0000-0002-9805-7050

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Phosphotransferases › Nucleotidyltransferases › DNA nucleotidyltransferases › DNA-directed DNA polymerase › DNA polymerase beta › SNP-Associated Substitutions of Amino Acid...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Polymorphisme génétique › Polymorphisme de nucléotide simple › SNP-Associated Substitutions of Amino Acid...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › SNP-Associated Substitutions of Amino Acid...
questionsmedicales.fr › Phénomènes génétiques › Mutagenèse › Substitution d'acide aminé › SNP-Associated Substitutions of Amino Acid...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de dynamique moléculaire › SNP-Associated Substitutions of Amino Acid...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Cinétique › SNP-Associated Substitutions of Amino Acid...
questionsmedicales.fr › Phénomènes génétiques › Réparation de l'ADN › SNP-Associated Substitutions of Amino Acid...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › SNP-Associated Substitutions of Amino Acid...