In Vivo Regulation of Active Matrix Metalloproteinase-8 (aMMP-8) in Periodontitis: From Transcriptomics to Real-Time Online Diagnostics and Treatment Monitoring.

Td-dentilisin aMMP-8 active matrix metalloproteinase-8 periodontitis proteomic transcriptomic

Journal

Diagnostics (Basel, Switzerland)

ISSN: 2075-4418

Titre abrégé: Diagnostics (Basel)

Pays: Switzerland

ID NLM: 101658402

Informations de publication

Date de publication:
15 May 2024

Historique:

received: 17 04 2024

revised: 09 05 2024

accepted: 12 05 2024

medline: 24 5 2024

pubmed: 24 5 2024

entrez: 24 5 2024

Statut: epublish

Résumé

This study investigated in vivo regulation and levels of active matrix metalloproteinase-8 (aMMP-8), a major collagenolytic protease, in periodontitis. Twenty-seven adults with chronic periodontitis (CP) and 30 periodontally healthy controls (HC) were enrolled in immunohistochemistry and transcriptomics analytics in order to assess Immunohistochemistry revealed significantly more In periodontal health, there are low aMMP-8 levels. The presence of

Sections du résumé

BACKGROUND BACKGROUND

This study investigated in vivo regulation and levels of active matrix metalloproteinase-8 (aMMP-8), a major collagenolytic protease, in periodontitis.

METHODS METHODS

Twenty-seven adults with chronic periodontitis (CP) and 30 periodontally healthy controls (HC) were enrolled in immunohistochemistry and transcriptomics analytics in order to assess

RESULTS RESULTS

Immunohistochemistry revealed significantly more

CONCLUSION CONCLUSIONS

In periodontal health, there are low aMMP-8 levels. The presence of

Identifiants

DOI: 10.3390/diagnostics14101011 PMID: 38786309

pubmed: 38786309

pii: diagnostics14101011

doi: 10.3390/diagnostics14101011

pii:

doi:

Types de publication

Journal Article