Characteristics of infant formula consumed in the first months of life and allergy in the EDEN mother-child cohort.
allergy
infant formula
long‐chain polyunsaturated fatty acids
partially hydrolysed formula
probiotics
Journal
Maternal & child nutrition
ISSN: 1740-8709
Titre abrégé: Matern Child Nutr
Pays: England
ID NLM: 101201025
Informations de publication
Date de publication:
24 May 2024
24 May 2024
Historique:
revised:
11
04
2024
received:
01
12
2023
accepted:
08
05
2024
medline:
24
5
2024
pubmed:
24
5
2024
entrez:
24
5
2024
Statut:
aheadofprint
Résumé
The evidence regarding the association between infant formula (IF) composition and the prevention of allergy and respiratory diseases remains sparse and inconclusive. This study aimed to evaluate whether some IF characteristics were associated with the risk of allergy or respiratory diseases in childhood. Among 1243 formula-fed children from the EDEN mother-child cohort, IF characteristics concerning long-chain polyunsaturated fatty acids (LCPUFAs) enrichment, prebiotic/probiotic enrichment, and hydrolysis of proteins were identified from the ingredients list. Eczema, wheezing, food allergy, asthma, and allergic rhinitis up to age 8 years were prospectively collected and summarized into four allergic and respiratory multimorbidity clusters. Associations between 4-month IF characteristics and risk of allergy or respiratory diseases were tested using logistic regressions adjusted on main confounders. The consumption of LCPUFA-enriched formula was not linked to allergic and respiratory multimorbidity clusters, but to a lower risk of any allergy, eczema, and wheezing. Probiotic-enriched formula consumption was associated with a lower risk of belonging to the 'Allergy without asthma' cluster (odds ratio [OR] [95% confidence interval, CI] = 0.63 [0.40-0.99]), and consumption of a formula enriched in Bifidobacterium lactis was associated with a lower risk of any allergy (OR [95% CI] = 0.59 [0.41-0.85]). Partially hydrolysed formula (pHF) consumption was associated with a higher risk of belonging to the 'Allergy without asthma' cluster (OR [95% CI] = 2.73 [1.65-4.51]). This study confirms the positive association between pHF consumption and the risk of allergy found in previous observational studies and suggests that consumption of LCPUFA-enriched or probiotic-enriched formula was associated with a lower risk of allergy.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13673Subventions
Organisme : ANR
ID : ANR-19-CE36-0008
Informations de copyright
© 2024 The Author(s). Maternal & Child Nutrition published by John Wiley & Sons Ltd.
Références
Adjibade, M., Davisse‐Paturet, C., Bernard, J. Y., Adel‐Patient, K., Divaret‐Chauveau, A., Lioret, S., Charles, M. A., & de Lauzon‐Guillain, B. (2022). Enrichment of infant formula with long‐chain polyunsaturated fatty acids and risk of infection and allergy in the nationwide ELFE birth cohort. Allergy, 77(5), 1522–1533. https://doi.org/10.1111/all.15137
Adjibade, M., Davisse‐Paturet, C., Divaret‐Chauveau, A., Adel‐Patient, K., Raherison, C., Dufourg, M. N., Lioret, S., Charles, M. A., & de Lauzon‐Guillain, B. (2022). Enrichment of formula in probiotics or prebiotics and risk of infection and allergic diseases up to age 5.5 years in the Nationwide ELFE Cohort. Journal of Nutrition, 152(4), 1138–1148. https://doi.org/10.1093/jn/nxac013
Amazouz, H., de Lauzon‐Guillain, B., Bourgoin‐Heck, M., Just, J., Beydon, N., Lezmi, G., Rancière, F., & Momas, I. (2021). Infant feeding clusters are associated with respiratory health and allergy at school age in the PARIS birth cohort. Allergy, 76(4), 1223–1234. https://doi.org/10.1111/all.14568
Andridge, R. R., & Little, R. J. (2009). The use of sample weights in hot deck imputation. Journal of Official Statistics, 25(1), 21–36.
Anto, J. M., Bousquet, J., Akdis, M., Auffray, C., Keil, T., Momas, I., Postma, D. S., Valenta, R., Wickman, M., Cambon‐Thomsen, A., Haahtela, T., Lambrecht, B. N., Lodrup Carlsen, K. C., Koppelman, G. H., Sunyer, J., Zuberbier, T., Annesi‐Maesano, I., Arno, A., Bindslev‐Jensen, C., … Xu, C. J. (2017). Mechanisms of the Development of Allergy (MeDALL): Introducing novel concepts in allergy phenotypes. Journal of Allergy and Clinical Immunology, 139(2), 388–399. https://doi.org/10.1016/j.jaci.2016.12.940
Arslanoglu, S., Moro, G. E., Schmitt, J., Tandoi, L., Rizzardi, S., & Boehm, G. (2008). Early dietary intervention with a mixture of prebiotic oligosaccharides reduces the incidence of allergic manifestations and infections during the first two years of life. The Journal of Nutrition, 138(6), 1091–1095. https://doi.org/10.1093/jn/138.6.1091
Asher, M. I., & Weiland, S. K. (1998). The International Study of Asthma and Allergies in Childhood (ISAAC). Clinical & Experimental Allergy, 28(Suppl 5), 52–66; discussion 90‐51. https://doi.org/10.1046/j.1365-2222.1998.028s5052.x
Beasley, R., Semprini, A., & Mitchell, E. A. (2015). Risk factors for asthma: Is prevention possible? The Lancet, 386(9998), 1075–1085. https://doi.org/10.1016/s0140-6736(15)00156-7
Betoko, A., Charles, M. A., Hankard, R., Forhan, A., Bonet, M., Saurel‐Cubizolles, M. J., Heude, B., & de Lauzon‐Guillain, B. (2013). Infant feeding patterns over the first year of life: Influence of family characteristics. European Journal of Clinical Nutrition, 67(6), 631–637. https://doi.org/10.1038/ejcn.2012.200
Birch, E. E., Khoury, J. C., Berseth, C. L., Castañeda, Y. S., Couch, J. M., Bean, J., Tamer, R., Harris, C. L., Mitmesser, S. H., & Scalabrin, D. M. (2010). The impact of early nutrition on incidence of allergic manifestations and common respiratory illnesses in children. The Journal of Pediatrics, 156(6), 902–906.e1. https://doi.org/10.1016/j.jpeds.2010.01.002
Braegger, C., Chmielewska, A., Decsi, T., Kolacek, S., Mihatsch, W., Moreno, L., Pieścik, M., Puntis, J., Shamir, R., Szajewska, H., Turck, D., & van Goudoever, J. (2011). Supplementation of infant formula with probiotics and/or prebiotics: A systematic review and comment by the ESPGHAN committee on nutrition. Journal of Pediatric Gastroenterology and Nutrition, 52(2), 238–250. https://doi.org/10.1097/MPG.0b013e3181fb9e80
Cai, X., Wardlaw, T., & Brown, D. W. (2012). Global trends in exclusive breastfeeding. International Breastfeeding Journal, 7(1), 12. https://doi.org/10.1186/1746-4358-7-12
Cuello‐Garcia, C., Fiocchi, A., Pawankar, R., Yepes‐Nuñez, J. J., Morgano, G. P., Zhang, Y., Agarwal, A., Gandhi, S., Terracciano, L., Schünemann, H. J., & Brozek, J. L. (2017). Prebiotics for the prevention of allergies: A systematic review and meta‐analysis of randomized controlled trials. Clinical and Experimental Allergy, 47(11), 1468–1477. https://doi.org/10.1111/cea.13042
Davisse‐Paturet, C., Raherison, C., Adel‐Patient, K., Divaret‐Chauveau, A., Bois, C., Dufourg, M. N., Lioret, S., Charles, M. A., & de Lauzon‐Guillain, B. (2019). Use of partially hydrolysed formula in infancy and incidence of eczema, respiratory symptoms or food allergies in toddlers from the ELFE cohort. Pediatric Allergy and Immunology, 30(6), 614–623. https://doi.org/10.1111/pai.13094
Delvert, R., Ghozal, M., Adel‐Patient, K., Kadawathagedara, M., Heude, B., Charles, M. A., Annesi‐Maesano, I., Tafflet, M., Leynaert, B., Varraso, R., de Lauzon‐Guillain, B., & Bédard, A. (2022). Maternal diet quality during pregnancy and allergic and respiratory multimorbidity clusters in children from the EDEN mother‐child cohort. Nutrients, 15(1), 146. https://doi.org/10.3390/nu15010146
Foiles, A. M., Kerling, E. H., Wick, J. A., Scalabrin, D. M. F., Colombo, J., & Carlson, S. E. (2016). Formula with long‐chain polyunsaturated fatty acids reduces incidence of allergy in early childhood. Pediatric Allergy and Immunology, 27(2), 156–161. https://doi.org/10.1111/pai.12515
Halken, S. (2004). Prevention of allergic disease in childhood: Clinical and epidemiological aspects of primary and secondary allergy prevention. Pediatric Allergy and Immunology, 15(Suppl 16), 9–32. https://doi.org/10.1111/j.1399-3038.2004.0148b.x
Heude, B., Forhan, A., Slama, R., Douhaud, L., Bedel, S., Saurel‐Cubizolles, M. J., Hankard, R., Thiebaugeorges, O., De Agostini, M., Annesi‐Maesano, I., Kaminski, M., & Charles, M. A. (2016). Cohort Profile: The EDEN mother‐child cohort on the prenatal and early postnatal determinants of child health and development. International Journal of Epidemiology, 45(2), 353–363. https://doi.org/10.1093/ije/dyv151
Lapillonne, A., Pastor, N., Zhuang, W., & Scalabrin, D. M. (2014). Infants fed formula with added long chain polyunsaturated fatty acids have reduced incidence of respiratory illnesses and diarrhea during the first year of life. BMC Pediatrics, 14, 168. https://doi.org/10.1186/1471-2431-14-168
de Lauzon‐Guillain, B., Davisse‐Paturet, C., Lioret, S., Ksiazek, E., Bois, C., Dufourg, M. N., Bournez, M., Nicklaus, S., Wagner, S., & Charles, M. A. (2018). Use of infant formula in the ELFE study: The association with social and health‐related factors. Maternal & Child Nutrition, 14(1), e12477. https://doi.org/10.1111/mcn.12477
Osborn, D. A., Sinn, J. K., & Jones, L. J. (2018). Infant formulas containing hydrolysed protein for prevention of allergic disease. Cochrane Database of Systematic Reviews, 2018(10), Cd003664. https://doi.org/10.1002/14651858.CD003664.pub6
Paller, A. S., Spergel, J. M., Mina‐Osorio, P., & Irvine, A. D. (2019). The atopic march and atopic multimorbidity: Many trajectories, many pathways. Journal of Allergy and Clinical Immunology, 143(1), 46–55. https://doi.org/10.1016/j.jaci.2018.11.006
Pastor, N., Soler, B., Mitmesser, S. H., Ferguson, P., & Lifschitz, C. (2006). Infants fed docosahexaenoic acid‐ and arachidonic acid‐supplemented formula have decreased incidence of bronchiolitis/bronchitis the first year of life. Clinical Pediatrics, 45(9), 850–855. https://doi.org/10.1177/1073858406289801
Pawankar, R., Walter Canonica, G., Holgate, S. T., Lockey, R. F., & Blaiss, M. S. (2013). White book on allergy: Executive summary (update 2013). World Allergy Organization.
Pinart, M., Benet, M., Annesi‐Maesano, I., von Berg, A., Berdel, D., Carlsen, K. C. L., Carlsen, K. H., Bindslev‐Jensen, C., Eller, E., Fantini, M. P., Lenzi, J., Gehring, U., Heinrich, J., Hohmann, C., Just, J., Keil, T., Kerkhof, M., Kogevinas, M., Koletzko, S., … Antó, J. M. (2014). Comorbidity of eczema, rhinitis, and asthma in IgE‐sensitised and non‐IgE‐sensitised children in MeDALL: A population‐based cohort study. The Lancet Respiratory Medicine, 2(2), 131–140. https://doi.org/10.1016/s2213-2600(13)70277-7
Schiess, S., Grote, V., Scaglioni, S., Luque, V., Martin, F., Stolarczyk, A., Vecchi, F., & Koletzko, B. (2010). Introduction of complementary feeding in 5 European countries. Journal of Pediatric Gastroenterology and Nutrition, 50(1), 92–98. https://doi.org/10.1097/MPG.0b013e31819f1ddc
Sestito, S., D'Auria, E., Baldassarre, M. E., Salvatore, S., Tallarico, V., Stefanelli, E., Tarsitano, F., Concolino, D., & Pensabene, L. (2020). The role of prebiotics and probiotics in prevention of allergic diseases in infants. Frontiers in Pediatrics, 8, 583946. https://doi.org/10.3389/fped.2020.583946
Shrier, I., & Platt, R. W. (2008). Reducing bias through directed acyclic graphs. BMC Medical Research Methodology, 8, 70. https://doi.org/10.1186/1471-2288-8-70
Sierra, C., Bernal, M. J., Blasco, J., Martínez, R., Dalmau, J., Ortuño, I., Espín, B., Vasallo, M. I., Gil, D., Vidal, M. L., Infante, D., Leis, R., Maldonado, J., Moreno, J. M., & Román, E. (2015). Prebiotic effect during the first year of life in healthy infants fed formula containing GOS as the only prebiotic: A multicentre, randomised, double‐blind and placebo‐controlled trial. European Journal of Nutrition, 54(1), 89–99. https://doi.org/10.1007/s00394-014-0689-9
de Silva, D., Halken, S., Singh, C., Muraro, A., Angier, E., Arasi, S., Arshad, H., Beyer, K., Boyle, R., du Toit, G., Eigenmann, P., Grimshaw, K., Hoest, A., Jones, C., Khaleva, E., Lack, G., Szajewska, H., Venter, C., Verhasselt, V., & Roberts, G. (2020). Preventing food allergy in infancy and childhood: Systematic review of randomised controlled trials. Pediatric Allergy and Immunology, 31(7), 813–826. https://doi.org/10.1111/pai.13273
Skórka, A., Pieścik‐Lech, M., Kołodziej, M., & Szajewska, H. (2018). Infant formulae supplemented with prebiotics: Are they better than unsupplemented formulae? An updated systematic review. British Journal of Nutrition, 119(7), 810–825. https://doi.org/10.1017/s0007114518000120
Sun, M., Luo, J., Liu, H., Xi, Y., & Lin, Q. (2021). Can mixed strains of lactobacillus and bifidobacterium reduce eczema in infants under three years of age? A meta‐analysis. Nutrients, 13(5), 1461. https://doi.org/10.3390/nu13051461
Vandenplas, Y., Munasir, Z., Hegar, B., Kumarawati, D., Suryawan, A., Kadim, M., Djais, J. T., Basrowi, R. W., & Krisnamurti, D. (2019). A perspective on partially hydrolyzed protein infant formula in nonexclusively breastfed infants. Korean Journal of Pediatrics, 62(5), 149–154. https://doi.org/10.3345/kjp.2018.07276
Victora, C. G., Bahl, R., Barros, A. J. D., França, G. V. A., Horton, S., Krasevec, J., Murch, S., Sankar, M. J., Walker, N., & Rollins, N. C. (2016). Breastfeeding in the 21st century: Epidemiology, mechanisms, and lifelong effect. The Lancet, 387(10017), 475–490. https://doi.org/10.1016/s0140-6736(15)01024-7
Wei, X., Jiang, P., Liu, J., Sun, R., & Zhu, L. (2020). Association between probiotic supplementation and asthma incidence in infants: A meta‐analysis of randomized controlled trials. Journal of Asthma, 57(2), 167–178. https://doi.org/10.1080/02770903.2018.1561893
WHO. (2003). Feeding and nutrition of infants and young children, guidelines for the WHO European region, with emphasis on the former Soviet countries. WHO.