Oxidatively-induced DNA base damage and base excision repair abnormalities in siblings of individuals with bipolar disorder DNA damage and repair in bipolar disorder.
Humans
Bipolar Disorder
/ genetics
Female
Male
Adult
DNA Repair
Siblings
DNA Damage
DNA Glycosylases
/ genetics
8-Hydroxy-2'-Deoxyguanosine
Oxidative Stress
/ genetics
Middle Aged
DNA Polymerase beta
/ genetics
DNA-(Apurinic or Apyrimidinic Site) Lyase
/ genetics
Case-Control Studies
Young Adult
Deoxyguanosine
/ analogs & derivatives
Excision Repair
Journal
Translational psychiatry
ISSN: 2158-3188
Titre abrégé: Transl Psychiatry
Pays: United States
ID NLM: 101562664
Informations de publication
Date de publication:
24 May 2024
24 May 2024
Historique:
received:
17
08
2023
accepted:
05
04
2024
revised:
01
04
2024
medline:
25
5
2024
pubmed:
25
5
2024
entrez:
24
5
2024
Statut:
epublish
Résumé
Previous evidence suggests elevated levels of oxidatively-induced DNA damage, particularly 8-hydroxy-2'-deoxyguanosine (8-OH-dG), and abnormalities in the repair of 8-OH-dG by the base excision repair (BER) in bipolar disorder (BD). However, the genetic disposition of these abnormalities remains unknown. In this study, we aimed to investigate the levels of oxidatively-induced DNA damage and BER mechanisms in individuals with BD and their siblings, as compared to healthy controls (HCs). 46 individuals with BD, 41 siblings of individuals with BD, and 51 HCs were included in the study. Liquid chromatography-tandem mass spectrometry was employed to evaluate the levels of 8-OH-dG in urine, which were then normalized based on urine creatinine levels. The real-time-polymerase chain reaction was used to measure the expression levels of 8-oxoguanine DNA glycosylase 1 (OGG1), apurinic/apyrimidinic endonuclease 1 (APE1), poly ADP-ribose polymerase 1 (PARP1), and DNA polymerase beta (POLβ). The levels of 8-OH-dG were found to be elevated in both individuals with BD and their siblings when compared to the HCs. The OGG1 and APE1 expressions were downregulated, while POLβ expressions were upregulated in both the patient and sibling groups compared to the HCs. Age, smoking status, and the number of depressive episodes had an impact on APE1 expression levels in the patient group while body mass index, smoking status, and past psychiatric history had an impact on 8-OH-dG levels in siblings. Both individuals with BD and unaffected siblings presented similar abnormalities regarding oxidatively-induced DNA damage and BER, suggesting a link between abnormalities in DNA damage/BER mechanisms and familial susceptibility to BD. Our findings suggest that targeting the oxidatively-induced DNA damage and BER pathway could offer promising therapeutic strategies for reducing the risk of age-related diseases and comorbidities in individuals with a genetic predisposition to BD.
Identifiants
pubmed: 38789433
doi: 10.1038/s41398-024-02901-3
pii: 10.1038/s41398-024-02901-3
doi:
Substances chimiques
DNA Glycosylases
EC 3.2.2.-
oxoguanine glycosylase 1, human
EC 3.2.2.-
8-Hydroxy-2'-Deoxyguanosine
88847-89-6
DNA Polymerase beta
EC 2.7.7.7
DNA-(Apurinic or Apyrimidinic Site) Lyase
EC 4.2.99.18
Deoxyguanosine
G9481N71RO
APEX1 protein, human
EC 4.2.99.18
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
207Informations de copyright
© 2024. The Author(s).
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