Endurance Training Provokes Arrhythmogenic Right Ventricular Cardiomyopathy Phenotype in Heterozygous Desmoglein-2 Mutants: Alleviation by Preload Reduction.

arrhythmogenic cardiomyopathy arrhythmogenic right ventricular cardiomyopathy (ARVC) desmoglein 2 desmosome endurance exercise intercalated disk mouse model preload-reducing therapy

Journal

Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304

Informations de publication

Date de publication:
30 Apr 2024
Historique:
received: 06 11 2023
revised: 20 04 2024
accepted: 23 04 2024
medline: 25 5 2024
pubmed: 25 5 2024
entrez: 25 5 2024
Statut: epublish

Résumé

Desmoglein-2 mutations are detected in 5-10% of patients with arrhythmogenic right ventricular cardiomyopathy (ARVC). Endurance training accelerates the development of the ARVC phenotype, leading to earlier arrhythmic events. Homozygous

Identifiants

DOI: 10.3390/biomedicines12050985 PMID: 38790949
pubmed: 38790949
pii: biomedicines12050985
doi: 10.3390/biomedicines12050985
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : Deutsche Forschungsgemeinschaft
ID : DFG FA413/3-1
Organisme : EU MAESTRIA, European Union`s Horizon 2020 research and innovation programme
ID : N°965286
Organisme : Intermediate fellowship
ID : FS/12/40/29712
Organisme : Interdisciplinary Center for Clinical Research within the Faculty of Medicine at RWTH Aachen University
ID : IZKF T9-2
Organisme : Interdisciplinary Center for Clinical Research within the Faculty of Medicine at RWTH Aachen University
ID : K7-4
Organisme : British Heart Foundation
ID : AA/18/2/34218
Pays : United Kingdom

Auteurs

Larissa Fabritz (L)

University Center of Cardiovascular Science and Department of Cardiology, University Heart and Vascular Center, University Hospital Hamburg Eppendorf, 20246 Hamburg, Germany.
German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, 20246 Hamburg, Germany.
Institute of Cardiovascular Sciences, University of Birmingham, Birmingham B15 2TT, UK.
Department of Cardiology, Section of Rhythmology, University Hospital Muenster, 48149 Münster, Germany.
ORCID: 0000-0002-9241-1733

Lisa Fortmueller (L)

University Center of Cardiovascular Science and Department of Cardiology, University Heart and Vascular Center, University Hospital Hamburg Eppendorf, 20246 Hamburg, Germany.
German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, 20246 Hamburg, Germany.
Department of Cardiology, Section of Rhythmology, University Hospital Muenster, 48149 Münster, Germany.
ORCID: 0000-0003-1222-8830

Katja Gehmlich (K)

Institute of Cardiovascular Sciences, University of Birmingham, Birmingham B15 2TT, UK.
Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX1 2JD, UK.
ORCID: 0000-0003-4019-1844

Sebastian Kant (S)

Institute for Molecular and Cellular Anatomy (MOCA), RWTH Aachen University, 52074 Aachen, Germany.
ORCID: 0000-0003-0675-7445

Marcel Kemper (M)

Institute of Cardiovascular Sciences, University of Birmingham, Birmingham B15 2TT, UK.
Department of Cardiology, Section of Rhythmology, University Hospital Muenster, 48149 Münster, Germany.
ORCID: 0000-0001-8906-5297

Dana Kucerova (D)

Department of Cardiology, Section of Rhythmology, University Hospital Muenster, 48149 Münster, Germany.

Fahima Syeda (F)

Institute of Cardiovascular Sciences, University of Birmingham, Birmingham B15 2TT, UK.

Cornelius Faber (C)

Clinic of Radiology, Translational Research Imaging Center (TRIC), University of Muenster, 48149 Münster, Germany.
ORCID: 0000-0001-7683-7710

Rudolf E Leube (RE)

Institute for Molecular and Cellular Anatomy (MOCA), RWTH Aachen University, 52074 Aachen, Germany.
ORCID: 0000-0002-5519-7379

Paulus Kirchhof (P)

University Center of Cardiovascular Science and Department of Cardiology, University Heart and Vascular Center, University Hospital Hamburg Eppendorf, 20246 Hamburg, Germany.
German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, 20246 Hamburg, Germany.
Institute of Cardiovascular Sciences, University of Birmingham, Birmingham B15 2TT, UK.
ORCID: 0000-0002-1881-0197

Claudia A Krusche (CA)

Institute for Molecular and Cellular Anatomy (MOCA), RWTH Aachen University, 52074 Aachen, Germany.
ORCID: 0000-0001-9914-9283

Classifications MeSH