Interaction between miR-142-3p and

Humans Brain-Derived Neurotrophic Factor / genetics MicroRNAs / genetics Female Male Polymorphism, Single Nucleotide Adult Multiple Sclerosis / genetics Middle Aged Interleukin-1beta / genetics Severity of Illness Index Genetic Predisposition to Disease
biomarker microRNA neuroinflammation proinflammatory cytokine synapsis synaptopathy

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
11 May 2024
Historique:
received: 29 03 2024
revised: 02 05 2024
accepted: 05 05 2024
medline: 25 5 2024
pubmed: 25 5 2024
entrez: 25 5 2024
Statut: epublish

Résumé

MiR-142-3p has recently emerged as key factor in tailoring personalized treatments for multiple sclerosis (MS), a chronic autoimmune demyelinating disease of the central nervous system (CNS) with heterogeneous pathophysiology and an unpredictable course. With its involvement in a detrimental regulatory axis with interleukin-1beta (IL1β), miR-142-3p orchestrates excitotoxic synaptic alterations that significantly impact both MS progression and therapeutic outcomes. In this study, we investigated for the first time the influence of individual genetic variability on the miR-142-3p excitotoxic effect in MS. We specifically focused on the single-nucleotide polymorphism Val66Met (rs6265) of the brain-derived neurotrophic factor (

Identifiants

DOI: 10.3390/ijms25105253 PMID: 38791290
pubmed: 38791290
pii: ijms25105253
doi: 10.3390/ijms25105253
pii:
doi:

Substances chimiques

Brain-Derived Neurotrophic Factor 0
MicroRNAs 0
MIRN142 microRNA, human 0
Interleukin-1beta 0
BDNF protein, human 7171WSG8A2
IL1B protein, human 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Italian Ministry of Health
ID : RF-2018-12366144
Organisme : Italian Ministry of University and Research
ID : MNESYS PE0000006 PNRR
Organisme : Fondazione Italiana Sclerosi Multipla (FISM) and financed or co-financed with the '5 per mille' public funding
ID : project grant 2019/S/1
Organisme : Fondazione Italiana Sclerosi Multipla (FISM) and financed or co-financed with the '5 per mille' public funding
ID : project grant 2022/S/2 to DC
Organisme : Private donations
ID : In memory of Veronica Tozzi
Organisme : Italian Ministry of Health
ID : GR-2018-12366154
Organisme : Fondazione Italiana Sclerosi Multipla (FISM) and financed or co-financed with the '5 per mille' public funding
ID : senior research fellowship 2020/BS/003
Organisme : Consiglio Nazionale delle Ricerche (CNR) ADOPT co-funded by FOE 2020 and FOE 2021
ID : Nuovi Biomarker Diagnostici e Terapeutici delle Malattie Neurodegenerative

Auteurs

Ettore Dolcetti (E)

Neurology Unit, IRCCS Neuromed, 86077 Pozzilli, Italy.
Ph.D. Program in Neuroscience, Department of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy.
ORCID: 0000-0002-4594-4895

Alessandra Musella (A)

Synaptic Immunopathology Laboratory, IRCCS San Raffaele Roma, 00163 Rome, Italy.
Department of Human Sciences and Quality of Life Promotion, University of Rome San Raffaele, 00163 Rome, Italy.

Sara Balletta (S)

Neurology Unit, IRCCS Neuromed, 86077 Pozzilli, Italy.
ORCID: 0000-0001-5524-6524

Luana Gilio (L)

Neurology Unit, IRCCS Neuromed, 86077 Pozzilli, Italy.
Faculty of Psychology, Uninettuno Telematic International University, 00186 Rome, Italy.
ORCID: 0000-0001-7132-9098

Antonio Bruno (A)

Neurology Unit, IRCCS Neuromed, 86077 Pozzilli, Italy.
Ph.D. Program in Neuroscience, Department of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy.

Mario Stampanoni Bassi (M)

Neurology Unit, IRCCS Neuromed, 86077 Pozzilli, Italy.

Gianluca Lauritano (G)

Neurology Unit, IRCCS Neuromed, 86077 Pozzilli, Italy.

Fabio Buttari (F)

Neurology Unit, IRCCS Neuromed, 86077 Pozzilli, Italy.
Department of Systems Medicine, Tor Vergata University, 00133 Rome, Italy.

Diego Fresegna (D)

Synaptic Immunopathology Laboratory, IRCCS San Raffaele Roma, 00163 Rome, Italy.
ORCID: 0000-0002-6943-1904

Alice Tartacca (A)

Ph.D. Program in Neuroscience, Department of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy.

Fabrizio Mariani (F)

Department of Systems Medicine, Tor Vergata University, 00133 Rome, Italy.

Federica Palmerio (F)

Ph.D. Program in Neuroscience, Department of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy.

Valentina Rovella (V)

Department of Systems Medicine, Tor Vergata University, 00133 Rome, Italy.
ORCID: 0000-0002-3311-486X

Rosangela Ferese (R)

Neurology Unit, IRCCS Neuromed, 86077 Pozzilli, Italy.
ORCID: 0000-0001-8899-0309

Stefano Gambardella (S)

Neurology Unit, IRCCS Neuromed, 86077 Pozzilli, Italy.
Department of Biomolecular Sciences, University of Urbino "Carlo Bo", 61029 Urbino, Italy.

Emiliano Giardina (E)

Genomic Medicine Laboratory, IRCCS Fondazione Santa Lucia, 00179 Rome, Italy.
Department of Biomedicine and Prevention, University of Rome "Tor Vergata", 00133 Rome, Italy.

Annamaria Finardi (A)

Clinical Neuroimmunology Unit, Institute of Experimental Neurology (INSpe), Division of Neuroscience, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.
Faculty of Medicine and Surgery, Vita e Salute San Raffaele University, 20132 Milan, Italy.

Roberto Furlan (R)

Clinical Neuroimmunology Unit, Institute of Experimental Neurology (INSpe), Division of Neuroscience, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.
Faculty of Medicine and Surgery, Vita e Salute San Raffaele University, 20132 Milan, Italy.
ORCID: 0000-0001-7376-9425

Georgia Mandolesi (G)

Synaptic Immunopathology Laboratory, IRCCS San Raffaele Roma, 00163 Rome, Italy.
Department of Human Sciences and Quality of Life Promotion, University of Rome San Raffaele, 00163 Rome, Italy.
ORCID: 0000-0003-3612-6820

Diego Centonze (D)

Neurology Unit, IRCCS Neuromed, 86077 Pozzilli, Italy.
Department of Systems Medicine, Tor Vergata University, 00133 Rome, Italy.

Francesca De Vito (F)

Neurology Unit, IRCCS Neuromed, 86077 Pozzilli, Italy.
ORCID: 0000-0002-6543-5756

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Interaction between miR-142-3p and
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Facteurs de croissance nerveuse › Facteur neurotrophique dérivé du cerveau › Interaction between miR-142-3p and
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN non traduit › Petit ARN non traduit › microARN › Interaction between miR-142-3p and
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Polymorphisme génétique › Polymorphisme de nucléotide simple › Interaction between miR-142-3p and
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Interaction between miR-142-3p and
questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Maladies auto-immunes du système nerveux › Maladies démyélinisantes auto-immunes du SNC › Sclérose en plaques › Interaction between miR-142-3p and
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Interaction between miR-142-3p and
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Monokines › Interleukine-1 › Interleukine-1 bêta › Interaction between miR-142-3p and
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Enquêtes et questionnaires › Enquêtes de santé › Indicateurs d'état de santé › Acuité des besoins du patient › Indice de gravité de la maladie › Interaction between miR-142-3p and
questionsmedicales.fr › Phénomènes génétiques › Génotype › Prédisposition génétique à une maladie › Interaction between miR-142-3p and