Clinical and Genomic Features of Patients with Renal Cell Carcinoma and Advanced Chronic Kidney Disease: Analysis of a Multi-Institutional Database.
BAP1
chronic kidney disease
genomics
mutation
renal cell carcinoma
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
18 May 2024
18 May 2024
Historique:
received:
22
04
2024
revised:
30
04
2024
accepted:
16
05
2024
medline:
25
5
2024
pubmed:
25
5
2024
entrez:
25
5
2024
Statut:
epublish
Résumé
Patients with advanced chronic kidney disease (ACKD) are at an increased risk of developing renal cell carcinoma (RCC), but molecular alterations in RCC specimens arising from ACKD and overall survival (OS) in affected patients are not well defined. Using the Oncology Research Information Exchange Network (ORIEN) Total Cancer Care Of 296 patients with RCC, 61 met the criteria for ACKD. The most common somatic mutations in the overall cohort were in Using the clinicogenomic ORIEN database, our study found lower rates of
Sections du résumé
BACKGROUND
BACKGROUND
Patients with advanced chronic kidney disease (ACKD) are at an increased risk of developing renal cell carcinoma (RCC), but molecular alterations in RCC specimens arising from ACKD and overall survival (OS) in affected patients are not well defined.
PATIENTS AND METHODS
METHODS
Using the Oncology Research Information Exchange Network (ORIEN) Total Cancer Care
RESULTS
RESULTS
Of 296 patients with RCC, 61 met the criteria for ACKD. The most common somatic mutations in the overall cohort were in
CONCLUSIONS
CONCLUSIONS
Using the clinicogenomic ORIEN database, our study found lower rates of
Identifiants
pubmed: 38791999
pii: cancers16101920
doi: 10.3390/cancers16101920
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : University of Colorado Cancer Center
ID : P30CA046934