Reduction of the Risk of Hepatocellular Carcinoma over Time Using Direct-Acting Antivirals: A Propensity Score Analysis of a Real-Life Cohort (PITER HCV).

Humans Carcinoma, Hepatocellular / epidemiology Male Antiviral Agents / therapeutic use Female Liver Neoplasms / epidemiology Middle Aged Propensity Score Aged Incidence Sustained Virologic Response Hepacivirus / drug effects Hepatitis C, Chronic / drug therapy Liver Cirrhosis / virology Prospective Studies Italy / epidemiology Risk Factors Cohort Studies Adult
direct-acting antiviral hepatitis C virus hepatocellular carcinoma real-life cohort sustained virological response

Journal

Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722

Informations de publication

Date de publication:
26 Apr 2024
Historique:
received: 28 03 2024
revised: 23 04 2024
accepted: 24 04 2024
medline: 25 5 2024
pubmed: 25 5 2024
entrez: 25 5 2024
Statut: epublish

Résumé

The treatment of hepatitis C virus (HCV) with direct-acting antivirals (DAA) leads to high sustained virological response (SVR) rates, but hepatocellular carcinoma (HCC) risk persists in people with advanced liver disease even after SVR. We weighted the HCC risk in people with cirrhosis achieving HCV eradication through DAA treatment and compared it with untreated participants in the multicenter prospective Italian Platform for the Study of Viral Hepatitis Therapies (PITER) cohort. Propensity matching with inverse probability weighting was used to compare DAA-treated and untreated HCV-infected participants with liver cirrhosis. Kaplan-Meier analysis and competing risk regression analysis were performed. Within the first 36 months, 30 de novo HCC cases occurred in the untreated group (

Identifiants

DOI: 10.3390/v16050682 PMID: 38793565
pubmed: 38793565
pii: v16050682
doi: 10.3390/v16050682
pii:
doi:

Substances chimiques

Antiviral Agents 0

Types de publication

Journal Article Multicenter Study

Langues

eng

Sous-ensembles de citation

IM

Auteurs

Maria Giovanna Quaranta (MG)

Center for Global Health, Istituto Superiore di Sanità (ISS), 00161 Rome, Italy.
ORCID: 0000-0002-1077-1488

Luisa Cavalletto (L)

Department of Medicine-DIMED, Clinica Medica 5, Refering Regional Center for Liver Diseases, University Hospital, Padua University, 35122 Padova, Italy.
ORCID: 0000-0002-7368-279X

Francesco Paolo Russo (FP)

Department of Surgery, Oncology and Gastroenterology, Gastroenterology Unit, University of Padua, 35122 Padua, Italy.
ORCID: 0000-0003-4127-8941

Vincenza Calvaruso (V)

Gastroenterology and Hepatology Unit, PROMISE, University of Palermo, 90133 Palermo, Italy.
ORCID: 0000-0002-0287-1059

Luigina Ferrigno (L)

Center for Global Health, Istituto Superiore di Sanità (ISS), 00161 Rome, Italy.

Alberto Zanetto (A)

Department of Surgery, Oncology and Gastroenterology, Gastroenterology Unit, University of Padua, 35122 Padua, Italy.
ORCID: 0000-0002-6734-7178

Benedetta Mattioli (B)

Center for Global Health, Istituto Superiore di Sanità (ISS), 00161 Rome, Italy.

Roberta D'Ambrosio (R)

Division of Gastroenterology and Hepatology, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy.

Valentina Panetta (V)

L'altrastatistica S.r.l., Consultancy & Training, Biostatistics Office, 00174 Rome, Italy.
ORCID: 0000-0001-6058-5045

Giuseppina Brancaccio (G)

Infectious Diseases Unit, Department of Molecular Medicine, University of Padua,35122 Padua, Italy.

Giovanni Raimondo (G)

Department of Internal Medicine, University Hospital of Messina, 98122 Messina, Italy.

Maurizia Rossana Brunetto (MR)

Department of Clinical and Experimental Medicine, University Hospital of Pisa, 56126 Pisa, Italy.
ORCID: 0000-0001-8364-9152

Anna Linda Zignego (AL)

Department of Experimental and Clinical Medicine, Interdepartmental Centre MASVE, University of Florence, 50121 Florence, Italy.

Carmine Coppola (C)

Department of Hepatology, Gragnano Hospital, 80054 Naples, Italy.

Andrea Iannone (A)

Section of Gastroenterology, Department of Emergency and Organ Transplantation, University of Bari, 70121 Bari, Italy.

Elisa Biliotti (E)

Infectious and Tropical Medicine Unit, Department of Public Health and Infectious Diseases, "Policlinico Umberto I" Hospital, Sapienza University of Rome, 00161 Rome, Italy.

Elena Rosselli Del Turco (E)

Infectious Diseases Unit, Department for Integrated Infectious Risk Management, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy.

Marco Massari (M)

Malattie Infettive, Azienda Unità Sanitaria Locale, IRCCS di Reggio Emilia, 42123 Reggio Emilia, Italy.

Anna Licata (A)

Infectious Diseases Unit, DIBIMIS, University of Palermo, 90133 Palermo, Italy.
ORCID: 0000-0003-0383-6121

Francesco Barbaro (F)

Department of Medicine, Infectious Diseases Unit, University of Padua, 35122 Padua, Italy.
ORCID: 0000-0003-4573-4668

Marcello Persico (M)

Internal Medicine and Hepatology Division, Department of Medicine, Surgery and Dentistry, "Scuola Medica Salernitana", University of Salerno, 84084 Baronissi, Italy.
ORCID: 0000-0002-1399-6498

Filomena Morisco (F)

Gastroenterology Unit, Federico II University, 80138 Naples, Italy.

Maurizio Pompili (M)

Internal Medicine and Gastroenterology, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Largo Agostino Gemelli, 00136 Rome, Italy.

Federica Cerini (F)

Department of Clinical Sciences and Community Health, University of Milan, Hepatology Unit, San Giuseppe Hospital, 20123 Milan, Italy.
ORCID: 0000-0003-3568-1531

Massimo Puoti (M)

Infectious Disease Unit, Niguarda Hospital, 20142 Milan, Italy.
School of Medicine, University of Milano-Bicocca, 20126 Milan, Italy.

Teresa Santantonio (T)

Infectious Diseases Unit, Department of Clinical and Surgical Sciences, University of Foggia, AOU Policlinico Riuniti Foggia, 71122 Foggia, Italy.
ORCID: 0000-0002-4342-6904

Antonio Craxì (A)

Gastroenterology and Hepatology Unit, PROMISE, University of Palermo, 90133 Palermo, Italy.

Loreta A Kondili (LA)

Center for Global Health, Istituto Superiore di Sanità (ISS), 00161 Rome, Italy.
Internal Medicine, UniCamillus-Saint Camillus International University of Health Sciences, 00131 Rome, Italy.
ORCID: 0000-0003-2656-224X

Liliana Chemello (L)

Department of Medicine-DIMED, Clinica Medica 5, Refering Regional Center for Liver Diseases, University Hospital, Padua University, 35122 Padova, Italy.
ORCID: 0000-0001-6584-4157

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Reduction of the Risk of Hepatocellular...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies du foie › Tumeurs du foie › Carcinome hépatocellulaire › Reduction of the Risk of Hepatocellular...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antiviraux › Reduction of the Risk of Hepatocellular...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies du foie › Tumeurs du foie › Reduction of the Risk of Hepatocellular...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Reduction of the Risk of Hepatocellular...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Score de propension › Reduction of the Risk of Hepatocellular...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Reduction of the Risk of Hepatocellular...
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questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Flaviviridae › Hepacivirus › Reduction of the Risk of Hepatocellular...
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