Alpha-1-Acid Glycoprotein Quantification via Spatial Proximity Analyte Reagent Capture Luminescence Assay: Application as Diagnostic and Prognostic Marker in Serum and Effusions of Cats with Feline Infectious Peritonitis Undergoing GS-441524 Therapy.

Cats Animals Feline Infectious Peritonitis / diagnosis Biomarkers / blood Orosomucoid / analysis Luminescent Measurements / methods Prognosis Antiviral Agents / therapeutic use Female Male Coronavirus, Feline / isolation & purification
AGP FCoV FIP GS-441524 SPARCLTM assay acute-phase proteins alpha-1-acid glycoprotein biomarker cat

Journal

Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722

Informations de publication

Date de publication:
16 May 2024
Historique:
received: 10 04 2024
revised: 08 05 2024
accepted: 09 05 2024
medline: 25 5 2024
pubmed: 25 5 2024
entrez: 25 5 2024
Statut: epublish

Résumé

Until recently, the diagnosis of feline infectious peritonitis (FIP) in cats usually led to euthanasia, but recent research has revealed that antiviral drugs, including the nucleoside analog GS-441524, have the potential to effectively cure FIP. Alpha-1-acid glycoprotein (AGP) has been suggested as a diagnostic marker for FIP. However, AGP quantification methods are not easily accessible. This study aimed to establish a Spatial Proximity Analyte Reagent Capture Luminescence (SPARCL

Identifiants

DOI: 10.3390/v16050791 PMID: 38793672
pubmed: 38793672
pii: v16050791
doi: 10.3390/v16050791
pii:
doi:

Substances chimiques

Biomarkers 0
Orosomucoid 0
Antiviral Agents 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Auteurs

A Katrin Helfer-Hungerbuehler (AK)

Clinical Laboratory, Department of Clinical Diagnostics and Services, Center for Clinical Studies, Vetsuisse Faculty, University of Zurich, CH-8057 Zurich, Switzerland.

Andrea M Spiri (AM)

Clinical Laboratory, Department of Clinical Diagnostics and Services, Center for Clinical Studies, Vetsuisse Faculty, University of Zurich, CH-8057 Zurich, Switzerland.
ORCID: 0000-0001-9009-8256

Theres Meili (T)

Clinical Laboratory, Department of Clinical Diagnostics and Services, Center for Clinical Studies, Vetsuisse Faculty, University of Zurich, CH-8057 Zurich, Switzerland.

Barbara Riond (B)

Clinical Laboratory, Department of Clinical Diagnostics and Services, Center for Clinical Studies, Vetsuisse Faculty, University of Zurich, CH-8057 Zurich, Switzerland.
ORCID: 0000-0003-2848-2091

Daniela Krentz (D)

LMU Small Animal Clinic, Centre for Clinical Veterinary Medicine, LMU Munich, D-80539 Munich, Germany.
ORCID: 0000-0002-6175-1153

Katharina Zwicklbauer (K)

LMU Small Animal Clinic, Centre for Clinical Veterinary Medicine, LMU Munich, D-80539 Munich, Germany.
ORCID: 0000-0003-0470-776X

Katharina Buchta (K)

LMU Small Animal Clinic, Centre for Clinical Veterinary Medicine, LMU Munich, D-80539 Munich, Germany.

Anna-Maria Zuzzi-Krebitz (AM)

LMU Small Animal Clinic, Centre for Clinical Veterinary Medicine, LMU Munich, D-80539 Munich, Germany.

Katrin Hartmann (K)

LMU Small Animal Clinic, Centre for Clinical Veterinary Medicine, LMU Munich, D-80539 Munich, Germany.
ORCID: 0000-0002-5256-863X

Regina Hofmann-Lehmann (R)

Clinical Laboratory, Department of Clinical Diagnostics and Services, Center for Clinical Studies, Vetsuisse Faculty, University of Zurich, CH-8057 Zurich, Switzerland.
ORCID: 0000-0001-9750-4296

Marina L Meli (ML)

Clinical Laboratory, Department of Clinical Diagnostics and Services, Center for Clinical Studies, Vetsuisse Faculty, University of Zurich, CH-8057 Zurich, Switzerland.
ORCID: 0000-0002-3609-2416

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Carnivora › Feliformia › Felidae › Felis › Chats › Alpha-1-Acid Glycoprotein Quantification via...
questionsmedicales.fr › Eucaryotes › Animaux › Alpha-1-Acid Glycoprotein Quantification via...
questionsmedicales.fr › Maladies de l'animal › Maladies des chats › Péritonite infectieuse féline › Alpha-1-Acid Glycoprotein Quantification via...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Alpha-1-Acid Glycoprotein Quantification via...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Glycoprotéines › Mucoprotéines › Orosomucoïde › Alpha-1-Acid Glycoprotein Quantification via...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Photométrie › Mesures de luminescence › Alpha-1-Acid Glycoprotein Quantification via...
questionsmedicales.fr › Diagnostic › Pronostic › Alpha-1-Acid Glycoprotein Quantification via...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antiviraux › Alpha-1-Acid Glycoprotein Quantification via...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Nidovirales › Coronaviridae › Coronavirus › Alphacoronavirus › Alphacoronavirus-1 › Coronavirus félin › Alpha-1-Acid Glycoprotein Quantification via...