Expression pattern of Runt-related transcription factor (RUNX) family members and the role of RUNX1 during kidney development.

Kidney development Runt-related transcription factor Ureteric bud

Journal

Biochemical and biophysical research communications
ISSN: 1090-2104
Titre abrégé: Biochem Biophys Res Commun
Pays: United States
ID NLM: 0372516

Informations de publication

Date de publication:
22 May 2024
Historique:
received: 27 03 2024
revised: 19 05 2024
accepted: 21 05 2024
medline: 26 5 2024
pubmed: 26 5 2024
entrez: 25 5 2024
Statut: aheadofprint

Résumé

Runt-related transcription factor (RUNX) family members play critical roles in the development of multiple organs. Mammalian RUNX family members, consisting of RUNX1, RUNX2, and RUNX3, have distinct tissue-specific expression and function. In this study, we examined the spatiotemporal expression patterns of RUNX family members in developing kidneys and analyzed the role of RUNX1 during kidney development. In the developing mouse kidney, RUNX1 protein was strongly expressed in the ureteric bud (UB) tip and weakly expressed in the distal segment of the renal vesicle (RV), comma-shaped body (CSB), and S-shaped body (SSB). In contrast, RUNX2 protein was restricted to the stroma, and RUNX3 protein was only expressed in immune cells. We also analyzed the expression of RUNX family members in the cynomolgus monkey kidney. We found that expression patterns of RUNX2 and RUNX3 were conserved between rodents and primates, whereas RUNX1 was only expressed in the UB tip, not in the RV, CSB, or SSB of cynomolgus monkeys, suggesting a species differences. We further evaluated the roles of RUNX1 using two different conditional knockout mice: Runx1

Identifiants

DOI: 10.1016/j.bbrc.2024.150155 PMID: 38795454
pubmed: 38795454
pii: S0006-291X(24)00691-0
doi: 10.1016/j.bbrc.2024.150155
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

150155

Informations de copyright

Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Motoko Yanagita reports financial support was provided by Japan Agency for Medical Research and Development. Motoko Yanagita reports a relationship with Mitsubishi Tanabe Pharma Corporation, Boehringer Ingelheim that includes: funding grants. None has patent pending to none. none If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Keiko Yano-Sakamoto (K)

Department of Nephrology, Graduate School of Medicine, Kyoto University, Kyoto, 606-8507, Japan. Electronic address: keikoyano@kuhp.kyoto-u.ac.jp.

Yuichiro Kitai (Y)

Department of Nephrology, Graduate School of Medicine, Kyoto University, Kyoto, 606-8507, Japan. Electronic address: ykitai@kuhp.kyoto-u.ac.jp.

Naoya Toriu (N)

Department of Nephrology, Graduate School of Medicine, Kyoto University, Kyoto, 606-8507, Japan; Institute for the Advanced Study of Human Biology (ASHBi), Kyoto University, Kyoto, 606-8501, Japan. Electronic address: ntoriu@kuhp.kyoto-u.ac.jp.

Shinya Yamamoto (S)

Department of Nephrology, Graduate School of Medicine, Kyoto University, Kyoto, 606-8507, Japan. Electronic address: syamamon@kuhp.kyoto-u.ac.jp.

Ken Mizuta (K)

Institute for the Advanced Study of Human Biology (ASHBi), Kyoto University, Kyoto, 606-8501, Japan; Department of Anatomy and Cell Biology, Graduate School of Medicine, Kyoto University, Kyoto, 606-8501, Japan. Electronic address: mizuta@anat2.med.kyoto-u.ac.jp.

Mitinori Saitou (M)

Institute for the Advanced Study of Human Biology (ASHBi), Kyoto University, Kyoto, 606-8501, Japan; Department of Anatomy and Cell Biology, Graduate School of Medicine, Kyoto University, Kyoto, 606-8501, Japan; Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, 606-8397, Japan. Electronic address: saitou@anat2.med.kyoto-u.ac.jp.

Tomoyuki Tsukiyama (T)

Institute for the Advanced Study of Human Biology (ASHBi), Kyoto University, Kyoto, 606-8501, Japan; Research Center for Animal Life Science, Shiga University of Medical Science, Shiga, 520-2192, Japan. Electronic address: ttsuki@belle.shiga-med.ac.jp.

Ichiro Taniuchi (I)

Laboratory for Transcriptional Regulation, RIKEN Center for Integrative Medical Sciences, Yokohama, 230-0045, Japan. Electronic address: ichiro.taniuchi@riken.jp.

Motomi Osato (M)

International Research Center for Medical Sciences, Kumamoto University, Kumamoto, 860-0811, Japan. Electronic address: motokuma@kumamoto-u.ac.jp.

Motoko Yanagita (M)

Department of Nephrology, Graduate School of Medicine, Kyoto University, Kyoto, 606-8507, Japan; Institute for the Advanced Study of Human Biology (ASHBi), Kyoto University, Kyoto, 606-8501, Japan. Electronic address: motoy@kuhp.kyoto-u.ac.jp.

Classifications MeSH