Innovative cascade reaction for 2H-indazole derivative synthesis.
2H-indazol
Cs2CO3
DMSO
Hydrazine
Pd catalysed
TMSOTf
Journal
Molecular diversity
ISSN: 1573-501X
Titre abrégé: Mol Divers
Pays: Netherlands
ID NLM: 9516534
Informations de publication
Date de publication:
26 May 2024
26 May 2024
Historique:
received:
16
02
2024
accepted:
09
04
2024
medline:
26
5
2024
pubmed:
26
5
2024
entrez:
26
5
2024
Statut:
aheadofprint
Résumé
In the realm of synthetic organic chemistry, by using a one-pot sequential combination of MCR, it is possible to manufacture chemical commodities (fine chemicals, agrochemicals, and pharmaceutical substances) that enhance our quality of life while generating less waste materials and increasing economic advantages. With this motivation, using a "one-pot" method with multiple components, we present a relatively simple way to make stereoselective substitute 2H-indazole analogues for this study. Firstly, functionalised 3-bromo-4-((methylthio)methyl) derivatives were produced using DMSO as both a carbon source and a solvent, in conjunction with TMSOTf as the Lewis acid promoter. These derivatives were then utilised in the synthesis of 2-H-indazole derivatives with an up to 80% yield using t-Bu
Identifiants
pubmed: 38796796
doi: 10.1007/s11030-024-10874-0
pii: 10.1007/s11030-024-10874-0
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2024. The Author(s), under exclusive licence to Springer Nature Switzerland AG.
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