5

5S-heudelotinone Drug discovery Gut microbiota Immune system Inflammatory bowel disease Intestinal barrier Short-chain fatty acids Total synthesis

Journal

Acta pharmaceutica Sinica. B
ISSN: 2211-3835
Titre abrégé: Acta Pharm Sin B
Pays: Netherlands
ID NLM: 101600560

Informations de publication

Date de publication:
May 2024
Historique:
received: 06 09 2023
revised: 22 12 2023
accepted: 19 01 2024
medline: 27 5 2024
pubmed: 27 5 2024
entrez: 27 5 2024
Statut: ppublish

Résumé

Aberrant changes in the gut microbiota are implicated in many diseases, including inflammatory bowel disease (IBD). Gut microbes produce diverse metabolites that can shape the immune system and impact the intestinal barrier integrity, indicating that microbe-mediated modulation may be a promising strategy for preventing and treating IBD. Although fecal microbiota transplantation and probiotic supplementation are well-established IBD therapies, novel chemical agents that are safe and exert strong effects on the gut microbiota are urgently needed. Herein, we report the total synthesis of heudelotinone and the discovery of 5

Identifiants

DOI: 10.1016/j.apsb.2024.02.020 PMID: 38799623 PMC: PMC11120280
pubmed: 38799623
doi: 10.1016/j.apsb.2024.02.020
pii: S2211-3835(24)00058-3
pmc: PMC11120280
doi:

Types de publication

Journal Article

Langues

eng

Pagination

2153-2176

Informations de copyright

© 2024 The Authors.

Déclaration de conflit d'intérêts

The authors declare no conflicts of interest.

Auteurs

Qing Meng (Q)

State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Nankai University, Tianjin 300353, China.

Jianshuang Guo (J)

State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Nankai University, Tianjin 300353, China.

Ke Lv (K)

College of Chemistry and Frontiers Science Center for New Organic Matter, Haihe Laboratory of Sustainable Chemical Transformations, Nankai University, Tianjin 300071, China.

Yang Liu (Y)

State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Nankai University, Tianjin 300353, China.

Jin Zhang (J)

State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Nankai University, Tianjin 300353, China.

Mingyue Li (M)

State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Nankai University, Tianjin 300353, China.

Xirui Cheng (X)

State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Nankai University, Tianjin 300353, China.

Shenghua Chen (S)

College of Chemistry and Frontiers Science Center for New Organic Matter, Haihe Laboratory of Sustainable Chemical Transformations, Nankai University, Tianjin 300071, China.

Xiaoguang Huo (X)

Accendatech Company, Ltd., Tianjin 300193, China.

Quan Zhang (Q)

State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Nankai University, Tianjin 300353, China.

Yue Chen (Y)

State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Nankai University, Tianjin 300353, China.
College of Chemistry and Frontiers Science Center for New Organic Matter, Haihe Laboratory of Sustainable Chemical Transformations, Nankai University, Tianjin 300071, China.

Jing Li (J)

State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Nankai University, Tianjin 300353, China.
College of Chemistry and Frontiers Science Center for New Organic Matter, Haihe Laboratory of Sustainable Chemical Transformations, Nankai University, Tianjin 300071, China.

Classifications MeSH