Skeletal Myoblast Cells Enhance the Function of Transplanted Islets in Diabetic Mice.
Animals
Islets of Langerhans Transplantation
/ methods
Diabetes Mellitus, Experimental
/ metabolism
Myoblasts, Skeletal
/ transplantation
Mice
Male
Insulin
/ metabolism
Neovascularization, Physiologic
Hepatocyte Growth Factor
/ metabolism
Mice, Inbred C57BL
Vascular Endothelial Growth Factor A
/ metabolism
Islets of Langerhans
/ metabolism
Chemokine CXCL12
/ metabolism
Blood Glucose
/ metabolism
Diabetes Mellitus, Type 1
/ metabolism
Signal Transduction
Insulin Secretion
Cell Differentiation
Journal
Journal of diabetes research
ISSN: 2314-6753
Titre abrégé: J Diabetes Res
Pays: England
ID NLM: 101605237
Informations de publication
Date de publication:
2024
2024
Historique:
received:
30
01
2024
revised:
05
04
2024
accepted:
23
04
2024
medline:
27
5
2024
pubmed:
27
5
2024
entrez:
27
5
2024
Statut:
epublish
Résumé
Islet transplantation (ITx) is an established and safe alternative to pancreas transplantation for type 1 diabetes mellitus (T1DM) patients. However, most ITx recipients lose insulin independence by 3 years after ITx due to early graft loss, such that multiple donors are required to achieve insulin independence. In the present study, we investigated whether skeletal myoblast cells could be beneficial for promoting angiogenesis and maintaining the differentiated phenotypes of islets. In vitro experiments showed that the myoblast cells secreted angiogenesis-related cytokines (vascular endothelial growth factor (VEGF), hepatocyte growth factor (HGF), and stromal-derived factor-1
Identifiants
pubmed: 38800586
doi: 10.1155/2024/5574968
pmc: PMC11126349
doi:
Substances chimiques
Insulin
0
Hepatocyte Growth Factor
67256-21-7
Vascular Endothelial Growth Factor A
0
Chemokine CXCL12
0
Blood Glucose
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
5574968Informations de copyright
Copyright © 2024 Takeshi Kado et al.
Déclaration de conflit d'intérêts
The authors declare no conflicts of interest.